Association of Circulating Magnesium Levels in Patients With Alzheimer's Disease From 1991 to 2021: A Systematic Review and Meta-Analysis
Front Aging Neurosci. 2022 Jan 10;13:799824. doi: 10.3389/fnagi.2021.799824.
Ke Du 1, Xi Zheng 1, Zi-Tai Ma 1, Jun-Ya Lv 1, Wen-Juan Jiang 1 2, Ming-Yan Liu 1
Alzheimer's disease (AD) remains a medical and social challenge worldwide. Magnesium (Mg) is one of the most frequently evaluated essential minerals with diverse biological functions in human body. However, the association between circulating Mg levels and AD remains controversial. We conducted a meta-analysis of 21 studies published between 1991 and 2021 to determine whether the Mg levels in the blood and cerebrospinal fluid (CSF) are abnormal in AD. Literatures were searched in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang Data without language limitations.
A pooled subject sample including 1,112 AD patients and 1,001 healthy controls (HCs) was available to assess Mg levels in serum and plasma; 284 AD patients and 117 HCs were included for Mg levels in CSF. It was found that serum and plasma levels of Mg were significantly reduced in AD patients compared with HCs (standardized mean difference SMD = -0.89; 95% confidence interval [CI] [-1.36, -0.43]; P = 0.000). There was statistically non-significant for Mg level in CSF between AD and HCs, whereas a decreased tendency were detected (SMD = -0.16; 95% CI [-0.50, 0.18]; P = 0.364). .In addition, when we analyzed the Mg levels of serum, plasma and CSF together, the circulating Mg levels in AD patients was significantly lower (SMD = -0.74, 95% CI [-1.13; -0.35]; P = 0.000).
These results indicate that Mg deficiency may be a risk factor of AD and Mg supplementation may be a potentially valuable adjunctive treatment for AD.
Systematic Review Registration: www.crd.york.ac.uk/PROSPERO/, registration number CRD42021254557.
 Download the PDF from VitaminDWiki
VitaminDWiki - Magnesium and Vitamin D contains
- Overview Magnesium and vitamin D
- Longevity experts take Vitamin D, Omega-3, and Magnesium - Patrick video Sept 2023
- The ONE Supplement All Longevity Experts Are Taking (Magnesium) - video and transcript Dec 2023
- Magnesium deficiency – causes and symptoms – May 2016
- Magnesium Depletion Score predicts increased risk of various health problems
- Vitamins and Metals needed by the Immune System – Jan 2020
- Magnesium: intake decreased, difficult to measure in body – Sept 2018
- Magnesium deficiency estimated by just 6 Yes No questions - Dec 2019
- Magnesium fights diabetes (yet again)– meta-analysis Nov 2021
- Magnesium in Healthcare (Rickets, Stones, Pregnancy, Depression, etc.) with level of evidence – Sept 2017
- Magnesium is great for health, topical much faster than oral, MgCl2 is the best – 2019
- Magnesium is important for health but levels are low – July 2018
- How to get lots of Magnesium – especially needed for Coimbra MS and Autoimmune Protocol
- Magnesium etc. reduced in crops (must supplement) – 2009
Mg and Vitamin D
- Intracellular Magnesium and Vitamin D - a few studies
- Vitamin D and Magnesium need each other - many studies
- Why Vitamin D is Useless without This Critical Nutrient (Magnesium) - Jan 2019
- 500 mg of Magnesium for 8 weeks increased Vitamin D by 4 ng – July 2020
- Magnesium and Vitamin D - pre-colon cancer – RCT Dec 2018
- Magnesium is vital to Vitamin D in 4 places (maybe 8) – March 2018
- Magnesium and Vitamin D – recent deficiencies, needed, synergistic - good overview 2017
- Vitamin D Cofactors in a nutshell
- Magnesium and Vitamin D - similar, different and synergistic
Magnesium topics gathered on a page
- Vitamin D, Omega-3, and Magnesium are synergistic - many studies
- Magnesium and Cancer - many studies
- Diabetes, Metabolic Syndrome and Magnesium - many studies
- Low Magnesium associated with severe COVID – many studies
- Calcium to Magnesium Ratio - many studies
- Magnesium Role in Health and Longevity - many studies
- Magnesium reduces pain - many studies
- Vitamin D and Magnesium need each other - many studies
- Pregnancy helped by Magnesium - many studies
VitaminDWiki - Cognitive and Magnesium
- Magnesium can reduce neuroinflammation and cognitive decline – Sept 2024
- 800 mg of Magnesium early in 3rd trimester significantly increased brain activity in preterm infants – RCT May 2024
- Alzheimer’s patients have less Magnesium – meta-analysis Jan 2022
- Less cognitive decline in women consuming more Magnesium (and vitamins) – Nov 2019
- IQ 4 points lower in male children if fluoridated water while pregnant (perhaps Magnesium) – Aug 2019
- Senior cognition poor if low vitamin D and low Magnesium intake – June 2019
- Magnesium may be an important way to treat brain trauma
- Dementia less likely with increased levels of Magnesium etc.
VitaminDWiki - Cognitive category
Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used
Dementia page - 50 items
see also Overview Alzheimer's-Cognition and Vitamin D
Overview Parkinson's and Vitamin D
Cardiovascular (
Click here for details
Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020
IQ levels around the world are falling (perhaps lower Vitamin D, Iodine, or Omega-3)
Search VitaminDWiki for "WHITE MATTER" 325 items as of March 2023
Types of evidence that Vitamin D helps brain problems - 2014
3341 visitors, last modified 08 Apr, 2022, |
ID | Name | Uploaded | Size | Downloads | |
---|---|---|---|---|---|
17358 | Mg Alz diagrarm.jpg | admin 08 Apr, 2022 | 118.19 Kb | 296 | |
17357 | Mg Alz.jpg | admin 08 Apr, 2022 | 58.13 Kb | 257 | |
17356 | Mg and Alz.pdf | admin 08 Apr, 2022 | 1.92 Mb | 260 |