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Alzheimer’s patients have less Magnesium – meta-analysis Jan 2022

Association of Circulating Magnesium Levels in Patients With Alzheimer's Disease From 1991 to 2021: A Systematic Review and Meta-Analysis

Front Aging Neurosci. 2022 Jan 10;13:799824. doi: 10.3389/fnagi.2021.799824.
Ke Du 1, Xi Zheng 1, Zi-Tai Ma 1, Jun-Ya Lv 1, Wen-Juan Jiang 1 2, Ming-Yan Liu 1

Alzheimer's disease (AD) remains a medical and social challenge worldwide. Magnesium (Mg) is one of the most frequently evaluated essential minerals with diverse biological functions in human body. However, the association between circulating Mg levels and AD remains controversial. We conducted a meta-analysis of 21 studies published between 1991 and 2021 to determine whether the Mg levels in the blood and cerebrospinal fluid (CSF) are abnormal in AD. Literatures were searched in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang Data without language limitations.
A pooled subject sample including 1,112 AD patients and 1,001 healthy controls (HCs) was available to assess Mg levels in serum and plasma; 284 AD patients and 117 HCs were included for Mg levels in CSF. It was found that serum and plasma levels of Mg were significantly reduced in AD patients compared with HCs (standardized mean difference SMD = -0.89; 95% confidence interval [CI] [-1.36, -0.43]; P = 0.000). There was statistically non-significant for Mg level in CSF between AD and HCs, whereas a decreased tendency were detected (SMD = -0.16; 95% CI [-0.50, 0.18]; P = 0.364). .In addition, when we analyzed the Mg levels of serum, plasma and CSF together, the circulating Mg levels in AD patients was significantly lower (SMD = -0.74, 95% CI [-1.13; -0.35]; P = 0.000).
These results indicate that Mg deficiency may be a risk factor of AD and Mg supplementation may be a potentially valuable adjunctive treatment for AD.
Systematic Review Registration: www.crd.york.ac.uk/PROSPERO/, registration number CRD42021254557.


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VitaminDWiki - Magnesium and Vitamin D contains

339 items in category, see also

Mg and Vitamin D

Dr. Dean

Number of studies in both of the categories of Magnesium and:

Bone 15,  Cardiovascular 17,   Diabetes 27. Depression 14,  Obesity 11,   Omega-3 33,  Zinc 23,  Pregnancy 10,  Headache 10,   Virus 25,   Calcium 26   Virus 25   Mortality 8   Hypertension 11   Inflammation 3   Pain 7 etc.

VitaminDWiki - Cognitive and Magnesium

VitaminDWiki - Cognitive category

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used
Dementia page - 50 items

366 items in Cognition category

see also Overview Alzheimer's-Cognition and Vitamin D
Overview Parkinson's and Vitamin D

Studies in both categories of Cognition and:
Cardiovascular (7 studies), Genetics (9 studies), Vitamin D Receptor (16 studies), Omega-3 (49 studies), Intervention (19 studies), Meta-analyses (22 studies), Depression (22 studies), Parkinson's (21 studies)
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Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020
IQ levels around the world are falling (perhaps lower Vitamin D, Iodine, or Omega-3)
Search VitaminDWiki for "WHITE MATTER" 325 items as of March 2023

Types of evidence that Vitamin D helps brain problems - 2014

Attached files

ID Name Comment Uploaded Size Downloads
17358 Mg Alz diagrarm.jpg admin 08 Apr, 2022 00:28 118.19 Kb 213
17357 Mg Alz.jpg admin 08 Apr, 2022 00:27 58.13 Kb 180
17356 Mg and Alz.pdf PDF 2022 admin 08 Apr, 2022 00:27 1.92 Mb 156