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Neurodegenerative diseases (AD, PD, MS, Dementia, etc.) fought by Vitamin D (in rodents) – Jan 2023


Vitamin D and neurodegenerative diseases

Heliyon. 2023 Jan 12;9(1):e12877. doi: 10.1016/j.heliyon.2023.e12877. eCollection 2023 Jan.
Weixia Wang 1, Yijin Li 1, Xianfang Meng 1

Neurodegenerative diseases, featured by progressive loss of structure or function of neurons, are considered incurable at present. Movement disorders like tremor and postural instability, cognitive or behavioral disorders such as memory impairment are the most common symptoms of them and the growing patient population of neurodegenerative diseases poses a serious threat to public health and a burden on economic development. Hence, it is vital to prevent the occurrence of the diseases and delay their progress. Vitamin D can be transformed into a hormone in vivo with both genomic and non-genomic actions, exerting diverse physiological effects. Cumulative evidence indicates that vitamin D can ameliorate neurodegeneration by regulating pertinent molecules and signaling pathways including maintaining Ca2+ homeostasis, reducing oxidative stress, inhibiting inflammation, suppressing the formation and aggregation of the pathogenic protein, etc. This review updates discoveries of molecular mechanisms underlying biological functions of vitamin D in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and vascular dementia. Clinical trials investigating the influence of vitamin D supplementation in patients with neurodegenerative diseases are also summarized. The synthesized information will probably provoke an enhanced understanding of the neuroprotective roles of vitamin D in the nervous system and provide therapeutic options for patients with neurodegenerative diseases in the future.
 Download the PDF from VitaminDWiki

VitaminDWiki - Overview Alzheimer's-Cognition and Vitamin D contains:

VitaminDWiki - Overview Parkinson's and Vitamin D contains

VitaminDWiki – Overview MS and vitamin D contains

Clinical interventions have shown that Vitamin D can prevent, treat, and even cure Multiple Sclerosis, at a tiny fraction of the cost of the drugs now used to treat it, and without side effects.

Summary: lack of consensus on how much to prevent, treat, or cure MS.

VitaminDWik – Multiple Sclerosis 32 percent less likely among those with more than 32 ng of vitamin D – Dec 2019

UV and Sunshine reduces MS risk

Other things also help

High Dose Vitamin D and cofactors

Number of MS studies which are also in other categories

  • 22 studies in Genetics - genes can restrict Vitamin D getting to the blood and to the cells
  • 12 studies in Vitamin D Receptor - gene which restricts D from getting to the cells
  • 7 studies in Vitamin D Binding Protein - gene which restricts D from getting to the cells
  • 21 studies in Ultraviolet light - may be even better than Vitamin D in preventing and treating MS
  • 9 studies in Omega-3 - which helps Vitamin D prevent and treat MS

VitaminDWiki - Dementia is associated with low vitamin D - many studies 48+

VitaminDWiki - Evidence that Vitamin D helps brain problems - 2014__


Attached files

ID Name Comment Uploaded Size Downloads
19283 Functions.jpg admin 24 Feb, 2023 131.98 Kb 118
19282 Vitamin D and neurodegenerative diseases.pdf admin 24 Feb, 2023 2.38 Mb 99