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Alzheimer’s cognitive decline is 3X faster if low vitamin D – May 2017

Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and Alzheimer's disease in older adults

Alzheimer's & Dementia, Available online 16 May 2017m https://doi.org/10.1016/j.jalz.2017.03.003
Catherine Fearta, , , Catherine Helmera, Bénédicte Merlea, François R. Herrmannb, Cédric Annweilerc, d, Jean-François Dartiguesa, Cécile Delcourta, Cécilia Samieria

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Introduction
Hypovitaminosis D has been associated with several chronic conditions; yet, its association with cognitive decline and the risk of dementia and Alzheimer's disease (AD) has been inconsistent.

Methods
The study population consisted of 916 participants from the Three-City Bordeaux cohort aged 65+, nondemented at baseline, with assessment of vitamin D status and who were followed for up to 12 years.

Results
In multivariate analysis, compared with individuals with 25(OH)D sufficiency (n = 151), participants with 25(OH)D deficiency (n = 218) exhibited a faster cognitive decline. A total of 177 dementia cases (124 AD) occurred: 25(OH)D deficiency was associated with a nearly three-fold increased risk of AD (hazard ratio = 2.85, 95% confidence interval 1.37–5.97).

Discussion
This large prospective study of French older adults suggests that maintaining adequate vitamin D status in older age could contribute to slow down cognitive decline and to delay or prevent the onset of dementia, especially of AD etiology.


Created by admin. Last Modification: Tuesday December 22, 2020 02:49:25 GMT-0000 by admin. (Version 6)

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14757 Alz 2017.pdf admin 22 Dec, 2020 960.26 Kb 317
12106 Feart.jpg admin 12 Jun, 2019 35.34 Kb 502