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8 genes associated with both Alzheimer’s and lowish Vitamin D – May 2019

The Journal of Nutritional Biochemistry. Vol 67, May 2019, Pages 123-137, https://doi.org/10.1016/j.jnutbio.2019.01.015


Note: this study did not apparently consider genes which reduce vitamin D getting to tissues

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A vast majority of the elderly population shows a mild to moderate vitamin D deficiency. Besides the well-known function of vitamin D, vitamin D receptor is also expressed in brain and is discussed to regulate several genes. However very little is known whether genes are regulated, associated with Alzheimer’s disease (AD). Here we investigate 117 genes, known to be affected in AD, in mouse brain samples with a mild vitamin D hypovitaminosis comparable to the vitamin D status of the elderly population (20%–30% deficiency). The 117 genes include two positive controls, Nep and Park7, already known to be affected by both AD and vitamin D hypovitaminosis. The 25 most promising candidates were verified in a second independent mouse cohort, resulting in eleven genes further evaluated against three additional housekeeping genes.
Three of the remaining eight significantly altered genes are involved in APP homeostasis

  • Snca,
  • Nep,
  • Psmb5),

and each one gene in

  • oxidative stress (Park7),
  • Inflammation (Casp4),
  • lipid metabolism (Abca1),
  • signal transduction (Gnb5) and
  • neurogenesis (Plat).

Our results tighten the link of vitamin D and AD and underline that vitamin D influences several genes also in brain, highlighting that a strong link not only to AD but also to other neurodegenerative diseases might exist.

Created by admin. Last Modification: Tuesday December 10, 2019 14:43:37 GMT-0000 by admin. (Version 5)

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11641 8 genes.jpg admin 23 Mar, 2019 09:59 42.70 Kb 186
11640 Alz sci-hub.pdf PDF 2019 admin 23 Mar, 2019 09:58 2.26 Mb 241
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