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APOE4 gene problems (Alzheimer’s) reduced by both Vitamin D and Omega-3 - Dec 2018

Using the APOE4 Gene to Determine Alzheimer's Care Dr. Issacson Dec 2018

  • Includes 3 minute video
  • “Tobacco plus the APOE4 gene presses the fast-forward button towards Alzheimer's disease”
  • “There were a variety of other studies that showed that people with two copies of the APOE4 gene should possibly start thinking about what their vitamin D level is.[7] Having an elevated vitamin D level—[or even high-normal] to, say, 50 to 70 in one study—actually may be even more protective for people with two copies of the APOE4 gene.”
  • “…. recent studies[9] have actually shown that people with the APOE4 gene may respond preferentially to omega-3 fatty acid supplementation. However, the key here is that it takes 2.5 years for the amount of omega-3s to really replenish the brain.[10]”


  1. Berkowitz CL, Mosconi L, Rahman A, Scheyer O, Hristov H, Isaacson RS. Clinical application of APOE in Alzheimer's prevention: a precision medicine approach. J Prev Alzheimers Dis. 2018;5:245-252.  Download the PDF from VitaminDWiki both Omega-3 and Vit D may prevent Alz APOE4
  2. Solomon A, Turunen H, Ngandu T, et al. Effect of the apolipoprotein E genotype on cognitive change during a multidomain lifestyle intervention: a subgroup analysis of a randomized clinical trial. JAMA Neurol. 2018;75:462-470. Abstract
  3. Kivipelto M,Rovio S, Ngandu T, et al. Apolipoprotein E ε4 magnifies lifestyle risks for dementia: a population-based study. J Cell Mol Med. 2008;12:2762-2771. Abstract
  4. Etnier JL, Caselli RJ, Reiman EM, et al. Cognitive performance in older women relative to ApoEepsilon4 genotype and aerobic fitness. Med Sci Sports Exerc. 2007;39:199-207. Abstract
  5. Head D, Bugg JM, Goate AM, et al. Exercise engagement as a moderator of the effects of APOE genotype on amyloid deposition. Arch Neurol. 2012;69:636-643. Abstract
  6. Brown BM, Peiffer JJ, Taddei K, et al. Physical activity and amyloid-β plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Molecular Psychiatry. 2012;18:875. Abstract
  7. Mosconi L, Murray J, Tsui WH, et al. Mediterranean diet and magnetic resonance imaging- assessed brain atrophy in cognitively normal individuals at risk for Alzheimer's disease. J Prev Alzheimers Dis. 2014;1:23-32. Abstract
  8. Martinez-Lapiscina EH, Galbete C, Corella D, et al. Genotype patterns at CLU, CR1, PICALM and APOE, cognition and Mediterranean diet: the PREDIMED-NAVARRA trial. Genes Nutr. 2014;9:393. Abstract
  9. Durazzo TC, Mattsson N, Weiner MW. Interaction of cigarette smoking history with APOE genotype and age on amyloid level, glucose metabolism, and neurocognition in cognitively normal elders. Nicotine Tob Res. 2016;18:204-211. Abstract
  10. Maddock J, Cavadino A, Power C, Hypponen E. 25-Hydroxyvitamin D, APOE ε4 genotype and cognitive function: findings from the 1958 British birth cohort. Eur J Clin Nutr. 2015;69:505-508. doi: 10.1038/ejcn.2014.201


Alzheimers-Cognition - Overview starts with

Items in both categories Cognitive and Omega-3 are listed here:

Created by admin. Last Modification: Sunday December 16, 2018 16:55:01 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
11030 Clinical Application of APOE.pdf admin 12 Dec, 2018 19:12 328.87 Kb 19
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