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Vascular dementia (after strokes) 32X more likely in Hypertensives with low vitamin D – Oct 2015

Vitamin D status and vascular dementia due to cerebral small vessel disease in the elderly Asian Indian population

Journal of the Neurological Sciences, Online: October 30, 2015, DOI: http://dx.doi.org/10.1016/j.jns.2015.10.050
Puttachandra Prabhakar, Sadanandavalli Retnaswami Chandra, Manjunath Supriya, Thomas Gregor Issac, Chandrajit Prasad, Rita Christopher rita.nimhans at yahoo.com

Highlights
•Vitamin D deficiency is associated with 2.2-fold increase in odds of vascular dementia due to cerebral small vessel disease.
•In hypertensives with vitamin D deficiency and insufficiency, the odds were found to be 30.6-fold and 14.4-fold, respectively.
•Screening for vitamin D status could help in reducing the risk of VaD due to cerebral SVD.

Vitamin D plays vital roles in human health and recent studies have shown its beneficial effect on brain functioning. The present study was designed to evaluate the association of vitamin D with vascular dementia (VaD) due to cerebral small vessel disease (SVD) in Asian Indian population. 140 VaD patients aged ≥60 years with neuroimaging evidence of SVD, and 132 age and gender-matched controls, were investigated. Vitamin D status was estimated by measuring serum 25-hydroxy vitamin D.
Logistic regression model revealed that deficient levels of vitamin D (<12 ng/ml) were associated with 2.2-fold increase in odds of VaD after adjustment with covariates.
Hypertension was independently associated with 11.3-fold increased odds of VaD. In hypertensives with vitamin D deficiency and insufficiency (12–20 ng/ml), the odds were increased to 31.6-fold and 14.4-fold, respectively.
However, in hypertensives with vitamin D sufficiency (>20 ng/ml), the odds of VaD were increased by 3.8-fold only. Pearson correlation showed that serum vitamin D was inversely associated with systolic and diastolic blood pressure (r = −0.401 and −0.411, p < 0.01, respectively) in vitamin D-deficient subjects. Since the combined presence of hypertension and vitamin D deficiency increases the probability of developing VaD, screening for vitamin D status in addition to regular monitoring of blood pressure, could reduce the risk of VaD associated with cerebral SVD in the elderly Asian Indian subjects.


See also VitaminDWiki

Pages listed in BOTH of the categories Cognition and Stroke


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