The journal of nutrition, health & aging, October 2013
Benedetta Bartali bbartali at neriscience.com (1) (2) (3)
E. Devore (1) (2)
F. Grodstein (1) (2)
J. H. Kang (1) (2)
1. Department of Medicine, Channing Laboratory, Brigham and Women’s Hospital/Harvard Medical School, Boston, MA, USA
2. New England Research Institutes, Epidemiology, Watertown, MA, USA
3. New England Research Institutes, Epidemiology, 9 Galen St., Watertown, MA, USA
Background: Vitamin D may play a role in preserving cognitive function. However, there is a paucity of prospective studies on the relationship between vitamin D and cognition with aging. The aim of this study was to examine the association between plasma levels of vitamin D and subsequent cognitive function.
Methods: This is a prospective study including 1,185 women aged 60–70 years from the Nurses’ Health Study, who had plasma 25-hydroxy-vitamin D levels measured in 1989–1990 and completed an initial Telephone Interview of Cognitive Status approximately 9 years later. Subsequently, three follow-up cognitive assessments were conducted at 1.5–2.0 years intervals. We used multivariable-adjusted linear regression to model initial cognitive function, and mixed linear regression to model change in cognitive function over time.
Results: Lower vitamin D levels were associated with significantly worse cognitive function 9 years later. For example, the mean global composite score averaging all the cognitive tests was 0.20 lower (95% Confidence Interval (CI):−0.33,−0.08; p-trend=0.009) in women in the lowest quintile (median=14.1 ng/mL) compared with women in the highest quintile of vitamin D (median=38.4 ng/mL). The observed differences were equivalent to the effect estimates we found for women who were approximately 4–6 years apart in age. However, vitamin D levels were not significantly associated with subsequent cognitive decline during 6 years of follow-up.
Conclusions: Higher levels of plasma vitamin D in women aged 60–70 years were associated with better cognitive function about a decade later but were not associated with cognitive decline during 6 years of follow-up.
- Alzheimers-Cognition - Overview
- Vitamin D was one of the few drugs which improved cognition in seniors – Aug 2013
- Brain (Alzheimer’s) worked better with Vitamin D intervention – meta-analysis July 2013
- Infectious burden linked to cognitive decline (both linked to low vitamin D) – March 2013
- Vitamin D reduces Alzheimer’s disease in at least 11 ways – Jan 2013
- Age-related cognitive decline in rats mitigated by Vitamin D intervention – RCT Oct 2012
- Cognitive Impairment 2.4X more likely if low vitamin D – meta-analysis July 2012
- "Senior moment" 25X more likely with low vitamin D - Feb 2012
- Dementia 19X more likely if low vitamin D – Jan 2012
- Bennett DA. Diabetes and change in cognitive function. Arch Intern Med 2000;160(2):141–143. CrossRef
- Christakos S, Hewison M, Gardner DG, Wagner CL, Sergeev IN, Rutten E, Pittas AG, Boland R, Ferrucci L, Bikle DD. Vitamin D: beyond bone. Ann N Y Acad Sci. 2013 May;1287:45–58. CrossRef
- Boersma D, Demontiero O, Mohtasham Amiri Z, Hassan S, Suarez H, Geisinger D, Suriyaarachchi P, Sharma A, Duque G. Vitamin D Status in Relation to Postural Stability in the Elderly. J Nutr Health Aging 2012;3:270–275. CrossRef
- Peterson A, Mattek N, Clemons A, Bowman GL, Buracchio T, Kaye J, Quinn J. Serum vitamin D concentrations are associated with falling and cognitive function in older adults. J Nutr Health Aging 2012;10:898–901 CrossRef
- Annweiler C, Schott AM, Rolland Y, Blain H, Herrmann FR, Beauchet O. Dietary intake of vitamin D and cognition in older women: a large population-based study. Neurology 2010;75(20):1810–1816. CrossRef
- Llewellyn DJ, Lang IA, Langa KM, Melzer D. Vitamin D and cognitive impairment in the elderly U.S. population. J Gerontol A Biol Sci Med Sci 2011;66(1):59–65. CrossRef
- Buell JS, Dawson-Hughes B. Vitamin D and neurocognitive dysfunction: preventing “D”ecline? Mol Aspects Med 2008;29(6):415–422. CrossRef
- Garcion E, Wion-Barbot N, Montero-Menei CN, Berger F, Wion D. New clues about vitamin D functions in the nervous system. Trends Endocrinol Metab 2002;13(3):100–105. CrossRef
- Lehmann DJ, Refsum H, Warden DR, Medway C, Wilcock GK, Smith AD. The vitamin D receptor gene is associated with Alzheimer’s disease. Neurosci Lett 2011;504(2):79–82. CrossRef
- Butler MW, Burt A, Edwards TL, Zuchner S, Scott WK, Martin ER, et al. Vitamin D receptor gene as a candidate gene for Parkinson disease. Ann Hum Genet 2011;75(2):201–210. CrossRef
- Annweiler C, Llewellyn DJ, Beauchet O. Low serum vitamin D concentrations in Alzheimer’s disease: a systematic review and meta-analysis. J Alzheimers Dis 2013;33(3):659–674.
- Balion C, Griffith LE, Strifler L, Henderson M, Patterson C, Heckman G, et al. Vitamin D, cognition, and dementia: a systematic review and meta-analysis. Neurology 2012;79(13):1397–1405. CrossRef
- Peterson CA, Heffernan ME. Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women. J Inflamm (Lond) 2008;5:10. CrossRef
- Tarcin O, Yavuz DG, Ozben B, Telli A, Ogunc AV, Yuksel M, et al. Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects. J Clin Endocrinol Metab 2009;94(10):4023–4030. CrossRef
- Buell JS, Scott TM, Dawson-Hughes B, Dallal GE, Rosenberg IH, Folstein MF, et al. Vitamin D is associated with cognitive function in elders receiving home health services. J Gerontol A Biol Sci Med Sci 2009;64(8):888–895. CrossRef
- Seamans KM, Hill TR, Scully L, Meunier N, Andrillo-Sanchez M, Polito A, et al. Vitamin D status and measures of cognitive function in healthy older European adults. Eur J Clin Nutr 2010;64(10):1172–1178. CrossRef
- Rubin EH, Storandt M, Miller JP, Kinscherf DA, Grant EA, Morris JC, et al. A prospective study of cognitive function and onset of dementia in cognitively healthy elders. Arch Neurol 1998;55(3):395–401. CrossRef
- Przybelski RJ, Binkley NC. Is vitamin D important for preserving cognition? A positive correlation of serum 25-hydroxyvitamin D concentration with cognitive function. Arch Biochem Biophys 2007;460(2):202–205. CrossRef
- Lee DM, Tajar A, Ulubaev A, Pendleton N, O’Neill TW, O’Connor DB, et al. Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men. J Neurol Neurosurg Psychiatry 2009;80(7):722–729. CrossRef
- Brouwer-Brolsma EM, Feskens EJ, Steegenga WT, de Groot LC. Associations of 25-hydroxyvitamin D with fasting glucose, fasting insulin, dementia and depression in European elderly: the SENECA study. Eur J Nutr 2013;52(3):917–925. CrossRef
- Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL, Cherubini A, et al. Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med 2010;170(13):1135–1141. CrossRef
- Slinin Y, Paudel ML, Taylor BC, Fink HA, Ishani A, Canales MT, et al. 25-Hydroxyvitamin D levels and cognitive performance and decline in elderly men. Neurology 2010;74(1):33–41. CrossRef
- Hankinson SE, London SJ, Chute CG, Barbieri RL, Jones L, Kaplan LA, et al. Effect of transport conditions on the stability of biochemical markers in blood. Clin Chem 1989;35:2313–2316.
- Pittas AG, Sun Q, Manson JE, Dawson-Hughes B, Hu FB. Plasma 25-hydroxyvitamin D concentration and risk of incident type 2 diabetes in women. Diabetes Care 2010;33(9):2021–2023. CrossRef
- Okereke O, Hankinson SE, Hu FB, Grodstein F. Plasma C peptide level and cognitive function among older women without diabetes mellitus. Arch Intern Med 2005;165(14):1651–1656. CrossRef
- Brandt J, Folstein MF. Telephone Interview for Cognitive Status: Professional Manual. Lutz, FL: Psychological Assessment Resources, Inc; 2003.
- Wilson RS, Schneider JA, Barnes LL, Beckett LA, Aggarwal NT, Cochran EJ, et al. The apolipoprotein E e4 allele and decline in different cognitve systems during a 6-year period. Arch Neurol 2002;59:1154–1160. CrossRef
- Hollis BW, Kamerud JQ, Selvaag SR, Lorenz JD, Napoli JL. Determination of vitamin D status by radioimmunoassay with an 125I-labeled tracer. Clin Chem 1993;39(3):529–533.
- Lumley T, Diehr P, Emerson S, Chen L. The importance of the normality assumption in large public health data sets. Annu Rev Public Health 2002;23:151–169. CrossRef
- Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation 2008;117(4):503–511. CrossRef
- Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr 2006;84(1):18–28.
- Wilson RS, Leurgans SE, Boyle PA, Schneider JA, Bennett DA. Neurodegenerative basis of age-related cognitive decline. Neurology 2010;75(12):1070–1078. CrossRef
- Ware J, Snow K, Kosinski M, Bandek B. SF-36 health survey: manual and interpretation guide. Boston: The Health Institute, New England Medical Center. 1993.
- McHorney CA, Ware JEJ, Raczek AE. The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. Med Care 1993;31:247–263. CrossRef
- Dhesi JK, Bearne LM, Moniz C, Hurley MV, Jackson SH, Swift CG, et al. Neuromuscular and psychomotor function in elderly subjects who fall and the relationship with vitamin D status. J Bone Miner Res 2002;17(5):891–897. CrossRef
- Holick MF. Vitamin D deficiency. N Engl J Med 2007;357(3):266–281. CrossRef
- Giovannucci E, Liu Y, Hollis BW, Rimm EB. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med 2008;168(11):1174–1180. CrossRef
- Cigolini M, Iagulli MP, Miconi V, Galiotto M, Lombardi S, Targher G. Serum 25-hydroxyvitamin D3 concentrations and prevalence of cardiovascular disease among type 2 diabetic patients. Diabetes Care 2006;29(3):722–724. CrossRef
- Amer M, Qayyum R. Relation between serum 25-hydroxyvitamin D and C-reactive protein in asymptomatic adults (from the continuous National Health and Nutrition Examination Survey 2001 to 2006). Am J Cardiol 2012;109(2):226–230. CrossRef
- Moore ME, Piazza A, McCartney Y, Lynch MA. Evidence that vitamin D3 reverses age-related inflammatory changes in the rat hippocampus. Biochem Soc Trans 2005;33(Pt 4):573–577.
- Moore M, Piazza A, Nolan Y, Lynch MA. Treatment with dexamethasone and vitamin D3 attenuates neuroinflammatory age-related changes in rat hippocampus. Synapse 2007;61(10):851–861. CrossRef
- McCann JC, Ames BN. Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? Faseb J 2008;22(4):982–1001. CrossRef
- Masoumi A, Goldenson B, Ghirmai S, Avagyan H, Zaghi J, Abel K, et al. 1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer’s disease patients. J Alzheimers Dis 2009;17(3):703–717.
- Bishop NA, Lu T, Yankner BA. Neural mechanisms of ageing and cognitive decline. Nature 2010;464(7288):529–535. CrossRef
- Diniz BS, Butters MA, Albert SM, Dew MA, Reynolds CF. Late-life depression and risk of vascular dementia and Alzheimer’s disease: systematic review and metaanalysis of community-based cohort studies. Br J Psychiatry 2013;202(5):329–335. CrossRef
- James BD, Wilson RS, Barnes LL, Bennett DA. Late-Life Social Activity and Cognitive Decline in Old Age. J Int Neuropsychol Soc 2011;17(6):998–1005. CrossRef
- Clouston SAP, Brewster P, Kuh D, Richards M, Cooper R, Hardy R, et al. The Dynamic Relationship Between Physical Function and Cognition in Longitudinal Aging Cohorts. Epidemiol Rev 2013;35:33–50. CrossRef
- Seitz DP, Adunuri N, Gill SS, Rochon PA. Prevalence of Dementia and Cognitive Impairment Among Older Adults With Hip Fractures. Journal of the American Medical Directors Association 2011;12(8):556–564. CrossRef
- Luckhaus C, Mahabadi B, Grass-Kapanke B, Janner M, Willenberg H, Jager M, et al. Blood biomarkers of osteoporosis in mild cognitive impairment and Alzheimer’s disease. J Neural Transm 2009;116(7):905–911. CrossRef
- Bjorkman MP, Sorva AJ, Tilvis RS. Does elevated parathyroid hormone concentration predict cognitive decline in older people? Aging Clin Exp Res 2010;22(2):164–169.
- Gillette Guyonnet S, Abellan Van Kan G, Andrieu S, Barberger Gateau P, Berr C, Bonnefoy M, Dartigues JF, de Groot L, Ferry M, Galan P, Hercberg S, Jeandel C, Morris MC, Nourhashemi F, Payette H, Poulain JP, Portet F, Roussel AM, Ritz P, Rolland Y, Vellas B. IANA task force on nutrition and cognitive decline with aging. J Nutr Health Aging. 2007 Mar–Apr;11(2):132–152.
- Kong HY, Cheng DM, Pang W, Sun SD, Liu J, Huang CY, Jiang YG. Homocysteine levels and cognitive function scores measured with MMSE and BCAT of middleaged and elderly subjects in Tianjin City. J Nutr Health Aging 2013;6:527–532 CrossRef
- Kabagambe E, Wadley V, Kent S, Howard V, Crosson W, Al-Hamdan M, et al. The Relationship Between Long-Term Sunlight Radiation and Cognitive Decline in the REGARDS Cohort Study. Epidemiology 2012;23(5S):S–474.
- Sempos CT, Vesper HW, Phinney KW, Thienpont LM, Coates PM. Vitamin D status as an international issue: national surveys and the problem of standardization. Scandinavian journal of clinical and laboratory investigation. Supplementum 2012;243:32–40.
- Carter GD, Carter R, Jones J, Berry J. How accurate are assays for 25-hydroxyvitamin D? Data from the international vitamin D external quality assessment scheme. Clin Chem 2004;50(11):2195–2197. CrossRef
- Ginde AA, Liu MC, Camargo CA, Jr. Demographic differences and trends of vitamin D insufficiency in the US population, 1988–2004. Arch Intern Med 2009;169(6):626–632. CrossRef which is in Overview Deficiency of vitamin D