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How Vitamin D fights neurodegeneration (Multiple Sclerosis, Alzheimer’s, Dementia, etc) – Jan 2023

Vitamin D and neurodegenerative diseases

Heliyon https://doi.org/10.1016/j.heliyon.2023.e12877
Weixia Wang 1 YijinLi 1 Xianfang Meng 1

Neurodegenerative diseases, featured by progressive loss of structure or function of neurons, are considered incurable at present. Movement disorders like tremor and postural instability, cognitive or behavioral disorders such as memory impairment are the most common symptoms of them and the growing patient population of neurodegenerative diseases poses a serious threat to public health and a burden on economic development. Hence, it is vital to prevent the occurrence of the diseases and delay their progress. Vitamin D can be transformed into a hormone in vivo with both genomic and non-genomic actions, exerting diverse physiological effects.
Cumulative evidence indicates that vitamin D can ameliorate neurodegeneration by

  • regulating pertinent molecules and signaling pathways including maintaining Ca2+ homeostasis,
  • reducing oxidative stress,
  • inhibiting inflammation,
  • suppressing the formation and aggregation of the pathogenic protein, etc.

This review updates discoveries of molecular mechanisms underlying biological functions of vitamin D in neurodegenerative diseases including

  • Alzheimer’s disease,
  • Parkinson’s disease,
  • multiple sclerosis, and
  • vascular dementia.

Clinical trials investigating the influence of vitamin D supplementation in patients with neurodegenerative diseases are also summarized. The synthesized information will probably provoke an enhanced understanding of the neuroprotective roles of vitamin D in the nervous system and provide therapeutic options for patients with neurodegenerative diseases in the future.
 Download the PDF from VitaminDWiki

VitaminDWiki - Overview Parkinson's and Vitamin D contains

VitaminDWiki - Overview Alzheimer's-Cognition and Vitamin D contains

VitaminDWiki - Dementia is associated with low vitamin D - many studies

VitaminDWiki - Overview MS and vitamin D contains

Clinical interventions have shown that Vitamin D can prevent, treat, and even cure Multiple Sclerosis, at a tiny fraction of the cost of the drugs now used to treat it, and without side effects.

Summary: lack of consensus on how much to prevent, treat, or cure MS.

Attached files

ID Name Comment Uploaded Size Downloads
19089 Neurodegeneration.jpg admin 12 Jan, 2023 123.50 Kb 256
19088 Vitamin D and neurodegenerative diseases_CompressPdf.pdf admin 12 Jan, 2023 498.03 Kb 107