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Hypothesis – Alzheimer’s Disease results of hormone imbalance (vitamin D etc.) – Jan 2014

Why Vitamin D in Alzheimer’s Disease? The Hypothesis

Duygu Gezen-Ak, Selma Yılmazer, Erdinç Dursun (Handling Associate Editor: William Grant)

Scientists have worked for over a century to uncover the basis of Alzheimer’s disease (AD) with the ultimate goal of discovering a treatment. However, none of the approaches utilized have defined the exact cause of the disease or an ultimate treatment for AD.

In this review, we aim to define the role of vitamin D in AD from a novel and fundamental perspective and attempt to answer the following question:
Why should we seriously consider “simple” vitamin D as a “fundamental factor” in AD?
To answer this question, we explain the protective effects of vitamin D in the central nervous system and how the action of vitamin D and AD-type pathology overlap. Furthermore, we suggest that the role of vitamin D in AD includes not only vitamin D deficiency and vitamin D-related genes but also the disruption of vitamin D metabolism and action. This suggestion is supported by evidence that the disruption of vitamin D pathways mimic amyloid pathology.

We define the term “inefficient utilization of vitamin D” as any alteration in vitamin D-related genes, including

  • receptors,
  • the enzymes related to vitamin D metabolism or the transporters of vitamin D,

and we discuss the potential correlation of vitamin D status with the vulnerability of neurons to aging and neurodegeneration. Finally, in addition to the current knowledge that defines AD, we suggest that AD could be the result of a long-term hormonal imbalance in which the critical hormone is vitamin D, a secosteroid that has long been misnamed.

PMID: 24413618

See also VitaminDWiki

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