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Adding Vitamin D, Omega-3, etc to children’s milk improved memory (yet again) – RCT June 2018

Еffects of fortified milk on cognitive abilities in school-aged children: results from a randomized-controlled trial.

Eur J Nutr. 2018 Jun 7. doi: 10.1007/s00394-018-1734-x. [Epub ahead of print]
Petrova D1,2, Bernabeu Litrán MA3, García-Mármol E4, Rodríguez-Rodríguez M3, Cueto-Martín B4, López-Huertas E5, Catena A6, Fonollá J7.

VitaminDWiki summary
  • “The fortified milk contained high levels of various added micronutrients (e.g., vitamins A, B complex, C, D, and E, calcium, phosphorus, zinc) and PUFA (DHA+EPA),”
  • 4 of previous 6 studies of drink fortification also found working memory improvements
  • Most drink fortification studies have had Vitamin D and Omega-3

Improvement in digit span


  • Note: Puleva Max is a commerical supplement which to add to milk in Spain
  • VitamiDWiki is unaware of a similar milk augmentation product for the US
  • However, anyone can buy and add water-soluable vitamin D Amazon Example
    and Omega-3 emulsions Amazon example to their child's milk or drink
  • Something seems wrong with the Vitamin D units: 0.75 micrograms = 30 IU, a very small amount
    • which is 1/10X of milk fortified in the US

Fig. 2 Multiple regression results on % change scores.
The models controlled for age, gender, and changes in calcium, iron, ferritin, DHA, and BMI levels.
Coefficients are unstandardized B. R2=percentage of variance explained (average across imputations).
Dashed lines indicate non-significant effects

See also VitaminDWiki

 Download the PDF from VitaminDWiki

Micronutrients such as vitamins and minerals and long-chain polyunsaturated omega-3 fatty acids (PUFAs) are essential for children's brain development and cognitive functions. The current study investigated whether milk fortified with micronutrients and PUFA can result in improved cognitive function in mainstream school children.

One-hundred-and-nineteen children (age 8-14, 58 boys) were randomly allocated to a fortified milk group or a regular full milk control group. Participants consumed 0.6L/day of the milk for 5 months. We recorded relevant biochemical, anthropometric, and cognitive measures (working memory and processing speed) at the start of the study and at follow-up after 5 months.

The fortified milk significantly increased docosahexaenoic acid (DHA) (change from baseline of 28% [95% CI 17-39%] vs. -6% [95% CI - 13 to 0%] in the control group) and serum 25OH-vitamin D concentrations (41% [95% CI 30-52%] vs. 21% [95% CI 11-30%] in the control group).
The fortified milk improved working memory on one of two tests (32% [95% CI 17-47%] vs. 13% [95% CI 6-19%] in the control group).
The fortified milk also indirectly increased processing speed on one of two tests; this effect was small and completely mediated by increases in 25OH-vitamin D concentrations.

CONCLUSIONS:These results suggest that fortifying milk with micronutrients and PUFA could be an effective and practical way to aid children's cognitive development.

Created by admin. Last Modification: Saturday June 23, 2018 18:25:42 GMT-0000 by admin. (Version 14)

Attached files

ID Name Comment Uploaded Size Downloads
9940 Fortified benefits.jpg admin 09 Jun, 2018 34.56 Kb 745
9939 Fortified digit span.jpg admin 09 Jun, 2018 12.45 Kb 656
9938 fortified milk.jpg admin 09 Jun, 2018 56.51 Kb 676
9937  fortified milk.pdf admin 09 Jun, 2018 1.11 Mb 655