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Alzheimer’s Disease risk is 1.3X higher if Vitamin D deficient – meta-analysis Nov 2019

Vitamin D deficiency as a risk factor for dementia and Alzheimer’s disease: an updated meta-analysis

BMC Neurology volume 19, Article number: 284 (2019) Cite this article
Bingyan Chai, Fulin Gao, Ruipeng Wu, Tong Dong, Cheng Gu, Qiaoran Lin & Yi Zhang

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Alzheimer's and Vitamin D Genes

Alzheimer's and Vitamin D Cofactors


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Background
We aimed to comprehensively explore the associations between serum 25(OH)D deficiency and risk of dementia and Alzheimer’s disease(AD).

Methods
We systematically searched Pubmed, the Cochrane Library, Embase and the reference lists of pertinent review articles for relevant articles published from database inception up until January 2019. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with random effects models using the Stata 12.0 statistical software package.

Results
Twelve prospective cohort studies and four cross-sectional studies were included in this meta-analysis. The pooled HRs of dementia and AD, respectively, were 1.32 (95%CI: 1.16, 1.52) and 1.34 (95%CI: 1.13, 1.60) for vitamin D deficiency (< 20 ng/ml).
In the subgroup analyses, the pooled HRs of dementia and AD, respectively, were 1.48 (95%CI: 1.19, 1.85) and 1.51 (95%CI: 1.04, 2.18) for moderate vitamin D deficiency (10–20 ng/ml) and 1.20 (95%CI: 0.99, 1.44) and 1.36 (95%CI: 1.01, 1.84) for severe vitamin D deficiency (< 10 ng/ml).

Conclusion
There are significant associations between vitamin D deficiency and both dementia and AD. There are stronger associations between severe vitamin D deficiency (< 10 ng/ml) and both dementia and AD compared to moderate vitamin D deficiency (10–20 ng/ml).

Created by admin. Last Modification: Saturday November 16, 2019 20:02:59 GMT-0000 by admin. (Version 4)

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