Toggle Health Problems and D

Vitamin D injection is far better than oral for diabetics (poor gut) – RCT March 2017

See also similar studies at the bottom of this page

Guesses of Vitamin D response if poor gut

Bio FormSpeedDuration
10Injection ($$$)
or Calcidiol or Calcitriol
D - Slow
C -Fast
10 Sun/UVBSlowLong
(skin patch/cream, vagina)
Fast nano
9Nanoemulsion -mucosal
perhaps activates VDR
9?Inhaled (future)FastNormal
8Bio-D-Mulsion ForteNormalNormal
6Water soluble (Bio-Tech)NormalNormal
(some goes into gut)
3Coconut oil basedSlowNormal
2Food (salmon etc.)SlowNormal
2Olive oil based (majority)SlowNormal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months

Poor gut is associated with Gut diseases as well as Diabetes, Multiple Sclerosis, and many other diseases
Reminder - Vitamin D is absorbed in the first portion of the small intestine
Some gut problems which only occur in large intestine may not be a problem
On-going research at VitaminDWiki as of March 2017
  Getting Vitamin D into your body has details on each thype of vitamin D and the following chart

Parenteral vitamin D supplementation is superior to oral in vitamin D insufficient patients with type 2 diabetes mellitus

Diabetes & Metabolic Syndrome: Clinical Research & Reviews. online 6 March 2017, http://dx.doi.org/10.1016/j.dsx.2017.03.019
Awanindra Dwivedia, Balram Guptaa, Shalbha Tiwaria, d, Daliparthy D. Pratyusha, d, Saurabh Singhc, Surya Kumar Singha, sksendocrine at yahoo.com

Oral vitamin D supplementation is better than parenteral in improving vitamin D deficiency in individuals with no systemic illness. Our aim was to compare the efficacy of oral and parenteral routes of vitamin D supplementation on circulating serum 25(OH) vitamin D level in patients with type 2 diabetes mellitus.

Total 85 cases of with type 2 diabetes mellitus were screened for vitamin D status of which 71 patients were vitamin D insufficient/deficient. They were randomized into two intent to treat groups with different vitamin D supplementation protocols

  • (a) Oral-60000 IU per day for 5 days (group I; n = 40) and
  • (b) injectable-300000 IU intramuscularly once (group II; n = 31).

Baseline and one-month post supplementation 25(OH) vitamin D levels were measured in both the groups.

Baseline clinical characteristics and 25(OH) vitamin D levels were comparable in both the groups. Post treatment 25(OH) vitamin D level in

  • group I was 26.06 ± 9.06 ng/ml and in
  • group II was 49.69 ± 18.92 ng/ml.

After one month of vitamin D supplementation, increment in 25(OH) vitamin D level from baseline was significantly higher in group II than group I (p < 0.001).

Interpretation & conclusions
Injectable method of supplementation was better than oral route in improving serum 25 (OH) vitamin D status in patients with type 2 diabetes. The study suggested impaired absorption of vitamin D from the gastrointestinal tract in patients with type 2 diabetes mellitus and a need for parenteral route of vitamin D supplementation in deficient patients with type 2 diabetes mellitus.

Publisher wants $31.50 for the PDF
Purchased by VitaminDWiki

Injection references in the study

Bone Mineral Density - oral vs injection -Oct 2015


  • Full text online. 10 weeks of 60,000 IU vs 1 600,000 IU injection + daily 1 gram of Calcium
    "Although, with intramuscular route the serum vitamin D levels are maintained for 12 months, there is no improvement in BMD byeither route."
    Sufficiency (> 30 ng) at 12 month:s 85.7% injection, 22.9%. oral

Short URL = is.gd/BioForms

Vitamin D injection is far better than oral for diabetics (poor gut) – RCT March 2017        
12404 visitors, last modified 01 Sep, 2020,
Printer Friendly PDF this page! Follow this page for updates

Attached files

ID Name Comment Uploaded Size Downloads
7835 BMD inection.jpg admin 15 Mar, 2017 12:40 52.53 Kb 6587
7834 Injection RCT 2013.pdf PDF admin 15 Mar, 2017 12:18 270.75 Kb 1083
7833 Injection rickets 2014.pdf PDF 2014 admin 15 Mar, 2017 12:00 205.30 Kb 903
7832 Rickets Injection 2014.jpg admin 15 Mar, 2017 11:54 39.52 Kb 4117
See any problem with this page? Report it (WORKS NOV 2021)