J Pediatr Endocrinol Metab. 2012;25(5-6):607-10.
Villanueva J, Maranda L, Nwosu BU.
University of Massachusetts Medical School, Worcester, 01655, USA.
Celiac disease (CD) is an autoimmune enteropathy characterized by villus atrophy and malabsorption of essential nutrients. Vitamin D deficiency has been described in autoimmune diseases, but its status in prepubertal children with CD has not been adequately studied.
To determine the vitamin D status of prepubertal children with CD.
A retrospective study of prepubertal children aged 3-12 years with CD (n=24) who were compared to prepubertal, non-CD children of the same age (n=50). Children were included in the study if they had a diagnosis of CD by intestinal biopsy, and were not on a gluten-free diet (GFD). Patients were excluded if they had diseases of calcium or vitamin D metabolism, or were receiving calcium or vitamin D supplementation or had other autoimmune diseases. All subjects had their serum 25-hydroxyvitamin D [25(OH)D] level measured.
There was no difference in 25(OH)D level between the CD and non-CD children (27.58 +/- 9.91 versus 26.20 +/- 10.45, p = 0.59).
However, when the patients were subdivided into obese and non-obese groups, the non-obese CD patients had a significantly higher 25(OH)D level than the obese normal children (28.39 +/- 10.26 versus 21.58 +/- 5.67, p = 0.009).
In contrast, there was no difference in 25(OH)D level between non-obese CD patients and non-obese normal children (28.39 +/- 10.26 versus 30.64 +/-12.08, p = 0.52). The season of 25(OH)D measurement was not a significant confounder (p =0.7).
Our data showed no difference in 25(OH) D levels between normal children and those with CD when adjusted for body mass index.
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