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Vitamin D interactions with poor gut (Celiac, IBD, and Bariatric surgery) – several studies


IBD best practice advice includes Vitamin D - Jan 2024

AGA Clinical Practice Update on Diet and Nutritional Therapies in Patients With Inflammatory Bowel Disease: Expert Review
Gastroenterology. 2024 Jan 23:S0016-5085(23)05597-X. doi: 10.1053/j.gastro.2023.11.303
Jana G Hashash 1, Jaclyn Elkins 2, James D Lewis 3, David G Binion 4

Description: Diet plays a critical role in human health, but especially for patients with inflammatory bowel disease (IBD). Guidance about diet for patients with IBD are often controversial and a source of uncertainty for many physicians and patients. The role of diet has been investigated as a risk factor for IBD etiopathogenesis and as a therapy for active disease. Dietary restrictions, along with the clinical complications of IBD, can result in malnutrition, an underrecognized condition among this patient population. The aim of this American Gastroenterological Association (AGA) Clinical Practice Update (CPU) is to provide best practice advice statements, primarily to clinical gastroenterologists, covering the topics of diet and nutritional therapies in the management of IBD, while emphasizing identification and treatment of malnutrition in these patients. We provide guidance for tailored dietary approaches during IBD remission, active disease, and intestinal failure. A healthy Mediterranean diet will benefit patients with IBD, but may require accommodations for food texture in the setting of intestinal strictures or obstructions. New data in Crohn's disease supports the use of enteral liquid nutrition to help induce remission and correct malnutrition in patients heading for surgery. Parenteral nutrition plays a critical role in patients with IBD facing acute and/or chronic intestinal failure. Registered dietitians are an essential part of the interdisciplinary team approach for optimal nutrition assessment and management in the patient population with IBD.

Methods: This expert review was commissioned and approved by the AGA Clinical Practice Updates Committee and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership and underwent internal peer review by the CPU Committee and external peer review through standard procedures of Gastroenterology. The best practice advice statements were drawn from reviewing existing literature combined with expert opinion to provide practical advice on the role of diet and nutritional therapies in patients with IBD. Because this was not a systematic review, formal rating of the quality of evidence or strength of the presented considerations was not performed. Best Practice Advice Statements

  • BEST PRACTICE ADVICE 1: Unless there is a contraindication, all patients with IBD should be advised to follow a Mediterranean diet rich in a variety of fresh fruits and vegetables, monounsaturated fats, complex carbohydrates, and lean proteins and low in ultraprocessed foods, added sugar, and salt for their overall health and general well-being. No diet has consistently been found to decrease the rate of flares in adults with IBD. A diet low in red and processed meat may reduce ulcerative colitis flares, but has not been found to reduce relapse in Crohn's disease.
  • BEST PRACTICE ADVICE 2: Patients with IBD who have symptomatic intestinal strictures may not tolerate fibrous, plant-based foods (ie, raw fruits and vegetables) due to their texture. An emphasis on careful chewing and cooking and processing of fruits and vegetables to a soft, less fibrinous consistency may help patients with IBD who have concomitant intestinal strictures incorporate a wider variety of plant-based foods and fiber in their diets.
  • BEST PRACTICE ADVICE 3: Exclusive enteral nutrition using liquid nutrition formulations is an effective therapy for induction of clinical remission and endoscopic response in Crohn's disease, with stronger evidence in children than adults. Exclusive enteral nutrition may be considered as a steroid-sparing bridge therapy for patients with Crohn's disease.
  • BEST PRACTICE ADVICE 4: Crohn's disease exclusion diet, a type of partial enteral nutrition therapy, may be an effective therapy for induction of clinical remission and endoscopic response in mild to moderate Crohn's disease of relatively short duration.
  • BEST PRACTICE ADVICE 5: Exclusive enteral nutrition may be an effective therapy in malnourished patients before undergoing elective surgery for Crohn's disease to optimize nutritional status and reduce postoperative complications.
  • BEST PRACTICE ADVICE 6: In patients with IBD who have an intra-abdominal abscess and/or phlegmonous inflammation that limits ability to achieve optimal nutrition via the digestive tract, short-term parenteral nutrition may be used to provide bowel rest in the preoperative phase to decrease infection and inflammation as a bridge to definitive surgical management and to optimize surgical outcomes.
  • BEST PRACTICE ADVICE 7: We suggest the use of parenteral nutrition for high-output gastrointestinal fistula, prolonged ileus, short bowel syndrome, and for patients with IBD with severe malnutrition when oral and enteral nutrition has been trialed and failed or when enteral access is not feasible or contraindicated.
  • BEST PRACTICE ADVICE 8: In patients with IBD and short bowel syndrome, long-term parenteral nutrition should be transitioned to customized hydration management (ie, intravenous electrolyte support and/or oral rehydration solutions) and oral intake whenever possible to decrease the risk of developing long-term complications. Treatment with glucagon-like peptide-2 agonists can facilitate this transition.
  • BEST PRACTICE ADVICE 9: All patients with IBD warrant regular screening for malnutrition by their provider by means of assessing signs and symptoms, including unintended weight loss, edema and fluid retention, and fat and muscle mass loss. When observed, more complete evaluation for malnutrition by a registered dietitian is indicated. Serum proteins are no longer recommended for the identification and diagnosis of malnutrition due to their lack of specificity for nutritional status and high sensitivity to inflammation.
  • BEST PRACTICE ADVICE 10: All patients with IBD should be monitored for vitamin D and iron deficiency. Patients with extensive ileal disease or prior ileal surgery (resection or ileal pouch) should be monitored for vitamin B12 deficiency.
  • BEST PRACTICE ADVICE 11: All outpatients and inpatients with complicated IBD warrant co-management with a registered dietitian, especially those who have malnutrition, short bowel syndrome, enterocutaneous fistula, and/or are requiring more complex nutrition therapies (eg, parenteral nutrition, enteral nutrition, or exclusive enteral nutrition), or those on a Crohn's disease exclusion diet. We suggest that all newly diagnosed patients with IBD have access to a registered dietitian.
  • BEST PRACTICE ADVICE 12: Breastfeeding is associated with a lower risk for diagnosis of IBD during childhood. A healthy, balanced, Mediterranean diet rich in a variety of fruits and vegetables and decreased intake of ultraprocessed foods have been associated with a lower risk of developing IBD.

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Vitamin D and malabsorptive gastrointestinal conditions: A bidirectional relationship? Feb 2023

Reviews in Endocrine and Metabolic Disorders https://doi.org/10.1007/s11154-023-09792-7
Andrea Giustina1,2 • Luigi di Filippo1 • Agnese Allora1 • Daniel D. Bikle3 • Giulia Martina Cavestro4 •
David Feldman5 • Giovanni Latella6 • Salvatore Minisola7 • Nicola Napoli8 • Silvia Trasciatti9 • Melin Uygur1,10 •

PDF Table of Contents
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This paper is one of the outcomes of the 5 th International Conference "Controversies in Vitamin D" held in Stresa, Italy from 15 to 18 September 2021 as part of a series of annual meetings which was started in 2017. The scope of these meetings is to discuss controversial issues about vitamin D. Publication of the outcomes of the meeting in international journals allows a wide sharing of the most recent data with the medical and academic community. Vitamin D and malabsorptive gastrointestinal conditions was one of the topics discussed at the meeting and focus of this paper. Participants to the meeting were invited to review available literature on selected issues related to vitamin D and gastrointestinal system and to present their topic to all participants with the aim to initiate a discussion on the main outcomes of which are reported in this document. The presentations were focused on the possible bidirectional relationship between vitamin D and gastrointestinal malabsorptive conditions such as celiac disease, inflammatory bowel diseases (IBDs) and bariatric surgery. In fact, on one hand the impact of these conditions on vitamin D status was examined and on the other hand the possible role of hypovitaminosis D on pathophysiology and clinical course of these conditions was also evaluated. All examined malabsorptive conditions severely impair vitamin D status. Since vitamin D has known positive effects on bone this in turn may contribute to negative skeletal outcomes including reduced bone mineral density, and increased risk of fracture which may be mitigated by vitamin D supplementation. Due to the immune and metabolic extra-skeletal effects there is the possibility that low levels of vitamin D may negatively impact on the underlying gastrointestinal conditions worsening its clinical course or counteracting the effect of treatment. Therefore, vitamin D status assessment and supplementation should be routinely considered in all patients affected by these conditions. This concept is strengthened by the existence of a possible bidirectional relationship through which poor vitamin D status may negatively impact on clinical course of underlying disease. Sufficient elements are available to estimate the desired threshold vitamin D level above which a favourable impact on the skeleton in these conditions may be obtained. On the other hand, ad hoc controlled clinical trials are needed to better define this threshold for obtaining a positive effect of vitamin D supplementation on occurrence and clinical course of malabsorptive gastrointestinal diseases.
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8+ VitaminDWiki pages with CELIAC in title

This list is automatically updated

Items found: 11

About 1% of the population has Celiac Disease

30+ VitaminDWiki pages with IBD in title

This list is automatically updated

Items found: 30
Title Modified
Vitamin D interactions with poor gut (Celiac, IBD, and Bariatric surgery) – several studies 22 Nov, 2023
IBD associated with low vitamin D again (they need to take a gut-friendly form of Vitamin D) – Oct 2023 14 Oct, 2023
IBD treated in children by Vitamin D, especially if use more than 2,000 IU daily for 12 weeks – meta-analysis – Sept 2022 14 Sep, 2022
Vitamin D fights IBD, no consensus yet on dose size and type – Aug 2022 26 Aug, 2022
IBD is treated by Vitamin D and other Nutraceuticals – June 2022 23 Jun, 2022
IBD (Colitis, Crohn’s) was active 6X more often if low vitamin D – June 2015 30 May, 2022
IBD in children might be associated with low sun exposure 28 Feb, 2022
IBD strongly associated with low Vitamin D – Jan 2022 09 Jan, 2022
IBD and Crohn's patients need Vitamin D, even to increase drug efficacy (Vedolizumab) June 2021 29 Jun, 2021
IBD and UV dissertation - 2019 10 Sep, 2019
Vitamin D appears to fight Diabetes, MS, RA, Lupus, IBD, Hepatitis, Cancer, Psoriasis, Food allergy, etc – June 2019 17 Jul, 2019
IBD in Finland – 3X increase in 15 years, more prevalent further from equator – Nov 2012 14 May, 2019
Common cold incidence reduced by two thirds (500 IU for IBD with low vitamin D) – RCT Jan 2019 04 Jan, 2019
Risks of Colorectal Cancer, IBD, etc slightly increased if poor Vitamin D Receptor – Aug 2018 09 Dec, 2018
IBD relapse rate reduced by low Vitamin D - meta-analysis Nov 2018 27 Nov, 2018
Higher Vitamin D increased the benefit of anti-TNF- α drug used for IBD by 2.6 times – Jan 2017 31 Jan, 2017
IBD in Canadian children increasing 7% per year - Nov 2016 22 Nov, 2016
IBD UC and CD at risk of being vitamin D deficient – May 2011 04 Nov, 2016
IBD deficiencies of Iron and Vitamin D (and new Iron types) – June 2016 20 Jun, 2016
IBD helped by vitamin D but reluctant to state who helped, in what form, and how much – review Nov 2014 08 Jan, 2016
IBD more likely in areas with low UV ( and thus low vitamin D) – June 2014 05 Dec, 2015
Gut problems more likely if low vitamin D (IBD: 1.6, UC: 2.3) – meta-analysis Aug 2015 31 Oct, 2015
IBD (Collitis, Chron’s) was active 6X more often if low vitamin D – June 2015 03 Oct, 2015
Crohn’s disease deficient in vitamin K – IBD deficient in vitamins K and D – April 2011 17 Feb, 2015
Appears that IBD lowers vitamin D, which increases risk of cancer by 80 percent – Oct 2013 09 Jul, 2014
IBD surgery 5X more likely for non-caucasians with low vitamin D – Oct 2012 03 Nov, 2012
IBD and Crohn but not Colitis associated with low vitamin D – May 2011 05 Jun, 2012
IBD colorectal Cancer and vitamin D – Jan 2011 14 Mar, 2012
Dogs – like humans – with IBD were low on vitamin D – July 2011 14 Mar, 2012
IBD less costly when treated with vitamin D3 compared to D2 – Jan 2012 12 Jan, 2012

IBD risk reduced 16% if had been taking fish oil (Omega-3) supplements - Oct 2023

https://doi.org/10.1093/ibd/izad262


Reduced Nutrients due to IBD causes various skin problems - April 2024

Micronutrient Deficiencies in Patients With Inflammatory Bowel Disease
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See also Bariatric Surgery and Vitamin D - many studies


15+ VitaminDWiki pages with BARIATRIC in title

This list is automatically updated

Items found: 17
Title Modified
Following Bariatric surgery, weekly 50,000 IU of standard Vitamin D is not enough – Jan 2024 12 Jan, 2024
Vitamin D interactions with poor gut (Celiac, IBD, and Bariatric surgery) – several studies 22 Nov, 2023
Bariatric Surgery in Adolescents: 41% vitamin D deficient - meta-analysis Nov 2023 22 Nov, 2023
Bariatric surgery increases risk of bone fracture (less vitamin D adsorbed) - June 2023 09 Jun, 2023
Bariatric Surgery and Vitamin D - many studies 30 Apr, 2023
Poor heart rate variability for a year after Bariatric surgery if low vitamin D – Nov 2022 08 Nov, 2022
Bariatric Surgery lowered risk of severe liver disease (not a surprise) - Nov 2021 11 Nov, 2021
Weekly oral Vitamin D recommended before surgery (Bariatric in this case) – RCT June 2019 19 Jul, 2020
Bariatric Surgery is Bad for the Bone (reduce vitamin uptake, etc)– 2016 03 Nov, 2019
4 weeks of Omega-3 better than 2 week 800 calorie diet before Bariatric Surgery – RCT March 2019 23 Mar, 2019
Vitamin D probably important for Bariatric Surgery – April 2018 14 Jul, 2018
Obesity special issue in JAMA focuses on Bariatric Surgery (where the money is) – Jan 2018 20 Jan, 2018
Bones helped by Vitamin D, Physical Exercise, etc (this time - Bariatric Surgery) – RCT March 2016 30 Aug, 2017
Bariatric Surgery problems associated with season, latitude (low Vitamin D) – Dec 2015 25 Oct, 2016
Prior to Bariatric Surgery 96 percent were vitamin D deficient – July 2014 25 Oct, 2016
Bariatric surgery less than 30 ng of vitamin D – 82 pcnt teens, 100 pcnt of black teens – June 2012 25 Aug, 2014
Virtually all Bariatric Surgery patients vitamin D deficient – should we routinely supplement – Jan 2011 25 Aug, 2014

~200,000 Baritatric Surgeries in the US in 2020

Most of which significantly reduce the time to adsorb nutrients such as Vitamin D
solutions 1) Increase Vitamin D supplementation, 2) Use a non-oral form of Vitamin D


VitaminDWiki – Overview Gut and vitamin D has

  • Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
  • Celiac disease has a strong genetic component.
    • Most, but not all, people with celiac disease have a gene variant.
    • An adequate level vitamin D seems to decrease the probability of getting celiac disease.
    • Celiac disease causes poor absorption of nutrients such as vitamin D.
    • Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
    • The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
  • Review in Nov 2013 found that Vitamin D helped
    Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
  • All items in category gut and vitamin D 204 items

VitaminDWiki – Overview Gut and vitamin D contains gut-friendly information__

Gut-friendly, Sublingual, injection, topical, UV, sunshine

Getting Vitamin D into your body has the following chart
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Getting Vitamin D into your body also has the following
If poorly functioning gut
Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into the bloodstream
Fat-soluble Vitamins go thru the slow lymph system
   you can make your own sublingual by dissolving Vitamin D in water or use nano form
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into the bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into the bloodstream. Prescription-only?
Bio-Tech might be usefulit is also water-soluble
Vitamin D sprayed inside cheeks (buccal spray) - several studies
    and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gut

Bio FormSpeedDuration
10Injection ($$$)
or Calcidiol or Calcitriol
D - Slow
C -Fast
Long
10 Sun/UVBSlowLong
10Topical
(skin patch/cream, vagina)
Slow
Fast nano
Normal
9Nanoemulsion -mucosal
perhaps activates VDR
FastNormal
9?Inhaled (future)FastNormal
8Bio-D-Mulsion ForteNormalNormal
6Water soluble (Bio-Tech)NormalNormal
4Sublingual/spray
(some goes into gut)
FastNormal
3Coconut oil basedSlowNormal
2Food (salmon etc.)SlowNormal
2Olive oil based (majority)SlowNormal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months


VitaminDWiki – Gut category contains

204 items in GUT category - see also Overview Gut and vitamin D, See also Microbiome category listing has 37 items along with related searches.

VitaminDWiki – Irritable Bowel Syndrome and Vitamin D - many studies 19 as of June 2023


Asked Chat-GPT to compare IBS with IBD

Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD) are both chronic conditions that affect the digestive system, but they are distinct in their underlying causes, symptoms, and treatments. Here’s a comparison:

Nature of the Condition:
IBS: It is a functional disorder, which means the symptoms are not associated with any visible signs of damage or disease in the digestive tract. It affects how the bowel functions.
IBD: It is an autoimmune disease that involves chronic inflammation of the digestive tract. There is visible inflammation and damage to the digestive tract.

Common Forms:
IBS: It doesn't have different forms but can be classified based on the predominant symptom (IBS-D for diarrhea predominant, IBS-C for constipation predominant, IBS-M for mixed).
IBD: Common forms are Crohn's disease and ulcerative colitis.

Symptoms:
IBS: Abdominal pain, bloating, gas, diarrhea, constipation, mucus in the stool. The pain is often relieved by a bowel movement.
IBD: Abdominal pain, cramping, diarrhea, weight loss, fatigue, reduced appetite, blood in the stool, joint pain, and fevers.

Cause:
IBS: The exact cause is not known but it is thought to be related to a combination of abnormal gastrointestinal tract movements, increased sensitivity to pain, and possibly an imbalance of gut bacteria.
IBD: It is believed to be caused by an abnormal immune response, where the immune system attacks the cells of the digestive tract. Genetics, environmental factors, and an imbalance of gut bacteria are also thought to play a role.

Diagnosis:
IBS: Usually diagnosed based on symptoms and exclusion of other diseases. There are no specific laboratory tests to diagnose IBS.
IBD: Can be diagnosed through blood tests, stool tests, endoscopy, and imaging studies which show inflammation and damage in the digestive tract.

Treatment:
IBS: Treatment focuses on relieving symptoms. This may include changes in diet, medications to treat diarrhea or constipation, and stress reduction.
IBD: Treatment aims to reduce inflammation. This often involves medications such as anti-inflammatory drugs, immune system suppressors, and sometimes surgery to remove damaged portions of the digestive tract.

Complications:
IBS: It generally doesn’t cause complications but can significantly impact quality of life.
IBD: Can lead to serious complications such as strictures, abscesses, malnutrition, and increased risk of colon cancer.

Prevalence:
IBS: Is more common compared to IBD.
IBD: Less common but tends to be more severe.
It's important to note that although they have similarities in symptoms, IBS and IBD are fundamentally different. Proper diagnosis and management are crucial for both conditions. Always consult a healthcare provider for advice and information regarding diagnosis and treatment.


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Attached files

ID Name Comment Uploaded Size Downloads
21121 IBD skin problems.webp admin 22 Apr, 2024 43.69 Kb 40
21120 Micronutrient deficiences caused by IBD_CompressPdf.pdf admin 22 Apr, 2024 129.29 Kb 27
20709 IBD best_CompressPdf.pdf admin 26 Jan, 2024 400.67 Kb 69
19271 Relationships.jpg admin 23 Feb, 2023 100.84 Kb 541
19270 Occurance and Incidence.jpg admin 23 Feb, 2023 42.22 Kb 498
19269 Bidirectional Chart.jpg admin 23 Feb, 2023 94.16 Kb 553
19268 ToC bidirectional.jpg admin 23 Feb, 2023 67.43 Kb 549
19267 Vitamin D and malabsorptive gastrointestinal conditions - bidirectional_CompressPdf.pdf admin 23 Feb, 2023 411.02 Kb 248