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Migraine Headache association with poor gut – Feb 2020

Gut-brain Axis and Migraine Headache: A Comprehensive Review

Advanced Studies of the European Headache Federation (EHF-SAS)
Review J Headache Pain, 21 (1), 15 2020 Feb 13, DOI: 10.1186/s10194-020-1078-9
Mahsa Arzani 1, Soodeh Razeghi Jahromi 2, Zeinab Ghorbani 3, Fahimeh Vahabizad 1 4, Paolo Martelletti 5, Amir Ghaemi 6, Simona Sacco 7, Mansoureh Togha 8 9,

Microbionome category listing has 32 items along with related searches

A few relevant studies on VitaminDWiki

Resveratrol increases activation of the Vitamin D Receptor, which increases Vitamin D in cells

Overview Gut and vitamin D has the following summary

  • Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
  • Celiac disease has a strong genetic component.
    • Most, but not all, people with celiac disease have a gene variant.
    • An adequate level vitamin D seems to decrease the probability of getting celiac disease.
    • Celiac disease causes poor absorption of nutrients such as vitamin D.
    • Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
    • The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
  • Review in Nov 2013 found that Vitamin D helped
    Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
  • All items in category gut and vitamin D 197 items

Overview Gut and vitamin D contains gut-friendly information

Gut-friendly, Sublingual, injection, topical, UV, sunshine

Getting Vitamin D into your body has the following chart

Getting Vitamin D into your body also has the following
If poorly functioning gut
Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into bloodstream
   you can make your own sublinqual by dissovling Vitamin D in water or use nano form
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into bloodstream. Prescription only?
Bio-Tech might be usefulit is also water soluble
Vitamin D sprayed inside cheeks (buccal spray) - several studies
    and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gut

Bio FormSpeedDuration
10Injection ($$$)
or Calcidiol or Calcitriol
D - Slow
C -Fast
10 Sun/UVBSlowLong
(skin patch/cream, vagina)
Fast nano
9Nanoemulsion -mucosal
perhaps activates VDR
9?Inhaled (future)FastNormal
8Bio-D-Mulsion ForteNormalNormal
6Water soluble (Bio-Tech)NormalNormal
(some goes into gut)
3Coconut oil basedSlowNormal
2Food (salmon etc.)SlowNormal
2Olive oil based (majority)SlowNormal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months

Headache has the following on metals and migraines

Compared blood levels of 25 people with migraines to 25 people without GreenMedInfo

Metal MigraineNo Migraine Migraine Ratio
Cadmium 0.36 ug0.09 ug 4X MORE if increase
Iron0.97 ug0.48 ug2X MORE if increase
Lead1.48 ug0.78 ug 2X MORE if increase
Magnesium10.6 ug34.5 ug 3.5X LESS if increase
Zinc *0.24 ug 5.77 ug 24X LESS if increase

The items in Headache and Magnesium are listed here:

 Download the PDF from VSci-Hub via itaminDWiki


The terminology "gut-brain axis "points out a bidirectional relationship between the GI system and the central nervous system (CNS). To date, several researches have shown that migraine is associated with some gastrointestinal (GI) disorders such as

  • Helicobacter pylori (HP) infection,
  • irritable bowel syndrome (IBS), and
  • celiac disease (CD).

The present review article aims to discuss the direct and indirect evidence suggesting relationships between migraine and the gut-brain axis. However, the mechanisms explaining how the gut and the brain may interact in patients with migraine are not entirely clear. Studies suggest that this interaction seems to be influenced by multiple factors such as

  • inflammatory mediators (IL-1β, IL-6, IL-8, and TNF-α),
  • gut microbiota profile,
  • neuropeptides and serotonin pathway,
  • stress hormones and
  • nutritional substances.

Neuropeptides including CGRP, SP, VIP, NPY are thought to have antimicrobial impact on a variety of the gut bacterial strains and thus speculated to be involved in the bidirectional relationship between the gut and the brain. According to the current knowledge, migraine headache in patients harboring HP might be improved following the bacteria eradication.
Migraineurs with long headache history and high headache frequency have a higher chance of being diagnosed with IBS. IBS and migraine share some similarities and can alter gut microflora composition and thereby may affect the gut-brain axis and inflammatory status.
Migraine has been also associated with CD and the condition should be searched particularly in patients with migraine with occipital and parieto-occipital calcification at brain neuroimaging. In those patients, gluten-free diet can also be effective in reducing migraine frequency.
It has also been proposed that migraine may be improved by dietary approaches with beneficial effects on gut microbiota and gut-brain axis including appropriate consumption of fiber per day, adhering to a low glycemic index diet, supplementation with vitamin D, omega-3 and probiotics as well as weight loss dietary plans for overweight and obese patients.

Created by admin. Last Modification: Thursday February 25, 2021 16:13:30 GMT-0000 by admin. (Version 7)
Migraine Headache association with poor gut – Feb 2020        
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13503 Gut brain Fig 2.jpg admin 15 Feb, 2020 16:27 107.94 Kb 687
13502 Gut brain Fig1.jpg admin 15 Feb, 2020 16:27 92.37 Kb 636
13501 Gut-brain Axis and Migraine Headache.pdf PDF 2020 admin 15 Feb, 2020 16:18 1,020.66 Kb 594