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Personalized Vitamin D treatment of Multiple Sclerosis - Michael Cawley

Irish Acupuncturist and Nutritionist MIchael Cawley reversed 20 years of his MS symptoms with Coimbra Protocol.

He was then invited to San Paulo, Brazil by Dr.Cicero Coimbra MD (2017) and was added to list of Coimbra Protocol Practioners.

Upon clinical application of Coimbra Protocol he made several important discoveries

  • Many MS patients became worse on high doses of Vitamin D3 that had halted and reversed his own illness.
  • In large numbers of MS sufferer’s Vitamin D3 above 500 iu per kg of Vitamin D3 can worsen Multiple Sclerosis symptoms, while 400 - 500 iu per kg of body weight of Vitamin D can ease symptoms significantly. This worsening of symptoms is misdiagnosed as a multiple sclerosis “flare”, usually adding more D3 makes matters worse.
  • He believes that smaller doses (16,000 IU to 18,000 IU) of the properly matched Vitamin D3 and Magnesium supplement can have life-transforming effects on a small number of people, who will only be made worse with higher doses.
  • Vitamin D3 brand/form can determine whether Multiple Sclerosis responds to Vitamin D3. Clinical benefit can be determined by the oil the Vitamin D3 is combined with. He investigated multiple liquid and capsule brands of Vitamin D3 and recommends a select few that work the best.
  • Magnesium can make MS symptoms worse when it interacts with toxic heavy metals. He believes that symptoms often misdiagnosed as an MS flare.
  • Vitamin B2 can either improve or drastically worsen symptoms of Multiple Sclerosis. Worsening of symptoms are also often misdiagnosed as MS flare.
  • He had not found the parathyroid Hormone level to be a reliable indicator for success of Vitamin D3.
  • Note: He was taken off the list of Coimbra Protocol practitioners in May 2018 (no reason given).

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  • He advocates Personalized Vitamin D3 method which encourages people to listen to how they feel on different D3 forms/doses, also pioneers use of several forms of D3 used simultaneously.
  • He only recommends very specific brands/forms of Vitamin D3, Magnesium, Vitamin B2 , VItamin K2 which have proven themselves with MS cases.

In 18 months no calcium toxicity reported due to lower doses required to gain benefit, early cessation of Vitamin D3 supplementation if ionized calcium or serum calcium exceed highest reference range and use of pharma grade K2. www.menaquingold.com

Cawley Facebook post Sept 2019

  • Multiple Sclerosis is a catastrophic neurological illness. No pharmaceutical agent can halt the progression of multiple sclerosis. Multiple studies show Vitamin D3 deficiency to be a major risk factor for Multiple Sclerosis.
  • High dose Vitamin D3 therapy for MS, has been pioneered by Dr.Cicero Galli Coimbra MD, www.coimbraprotocol.com
  • In 2015, I used high dose Vitamin D3 therapy and the treatment helped reverse nearly 15 years of intractable symptoms. The following year, I was trained in the Coimbra protocol by Cicero Coimbra MD in Brazil.
  • Over 50% of the MS cases I have worked with notice a worsening of MS symptoms on the standard Coimbra Vitamin D3 dose of 1000 iu per kg of body weight. My advice is to never take a dose or form of Vitamin D3 that causes MS symptoms to worsen.
  • This group has hundreds of members who have personalized their use of Vitamin D3 magnesium and Vitamin B2 to halt and reverse the symptoms of Multiple Sclerosis.
  • As heavy metal contamination is so widespread and its symptoms mirror those of Multiple Sclerosis, heavy metal decontamination is a valued aspect of 'Personailzed Vitamin D3' and often achieves life changing results that no vitamin supplement can obtain.
  • Earthing as popularised by Clinton Ober encourages people to harness the healing power of the Earth by harvesting it's rich supply of free electrons. Earthing is clinically proven to strengthen the nervous, endocrine, circulatory and immune systems. Earthing is powerful tool for MS patients.I have enjoyed remarkable health benefits from Earthing and many in this group practice Earthing too.

Comments by Henry Lahore, founder of VitaminDWiki after a video conference with Mike on March 25, 2019

Mike noticed fast reactions by MSers to different forms of Vitamin D
When he had MSers take 20,000 IU of vitamin D, within a day they would either
1) Feel a lot better
2) Feel no difference
3) Feel lots of pain
I have not heard of such fast and strong reactions to Vitamin D before, and suspect not everyone has such strong reactions.
I suspect much of the difference was in the improved gut-friendliness of vitamin D emulsions, etc.
He also found differences of benefits between suppliers of Vitamin K2-7 and Magnesium

He. like I, had been taking Life Extension Super K, but he found that Menaquin Gold (India) was able to dissolve his artery plaque, whereas Super K did not. He sent me a bottle. It appears that form is not on Amazon is out of stock on the web (March 2019).

He, like I, had found Magnesium Chloride to be pretty good. He also recommends Magceutics Magtein

I mentioned that Ultraviolet light provides MSers with even more benefit than Vitamin D alone. MSers getting the same blood level response from UV and oral vitamin D got significantly fewer relapses. I suspect there is more than vitamin D is generated in the skin from the sun/UV
You can make your own powerful UV lamp from two parts for $40 (Amazon (US)
I have been using that UV lamp ~weekly in the winter since 2012

See also Vitamin D

Overview MS and vitamin D contains the following summary
Clinical interventions have shown that Vitamin D can prevent, treat, and even cure Multiple Sclerosis, at a tiny fraction of the cost of the drugs now used to treat it, and without side effects.

Summary: lack of consensus on how much to prevent, treat, or cure MS.

Multiple Sclerosis and (lots of) Vitamin D - book by patient on Coimbra protocol - Feb 2016
contains protocol description and list of Coimbra Facebook Groups

Vitamin D has treated Multiple Sclerosis for 16 years– Coimbra video April 2018
MS updates from Brazil
Table compares 4 High-dose vitamin D therapies 2 of which are Coimbra

Overview Gut and vitamin D contains gut-friendly information

Gut-friendly, Sublingual, injection, topical, UV, sunshine

Getting Vitamin D into your body has the following chart

Getting Vitamin D into your body also has the following
If poorly functioning gut
Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into the bloodstream
Fat-soluble Vitamins go thru the slow lymph system
   you can make your own sublingual by dissolving Vitamin D in water or use nano form
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into the bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into the bloodstream. Prescription-only?
Bio-Tech might be usefulit is also water-soluble
Vitamin D sprayed inside cheeks (buccal spray) - several studies
    and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gut

Bio FormSpeedDuration
10Injection ($$$)
or Calcidiol or Calcitriol
D - Slow
C -Fast
10 Sun/UVBSlowLong
(skin patch/cream, vagina)
Fast nano
9Nanoemulsion -mucosal
perhaps activates VDR
9?Inhaled (future)FastNormal
8Bio-D-Mulsion ForteNormalNormal
6Water soluble (Bio-Tech)NormalNormal
(some goes into gut)
3Coconut oil basedSlowNormal
2Food (salmon etc.)SlowNormal
2Olive oil based (majority)SlowNormal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months


High-dose vitamin D massively changes the gut bionome
Cooked dried beans or peas (pulses) reduce uptake of Vitamin D, Vitamin K by the gut by half – several studies
   If confirmed, should not take oil-based vitamin D with a pulse meal
Cancer stem cells and Vitamin D - many studies
Perhaps high dose Vitamin D along with Magnesium etc. activates stem cells, which then repair the brain

Nanoemulsion Vitamin D may be a substantially better form was updated after talking with Cawley
Bought 6 kinds of Vitamin D Emulsion - March 2019
There are a variety of Vitamin D emulsions on Amazon (US) as of 2019
Bio Emulsion Forte is what I started buying in 2012.
I have given out 3 bottles (as of 2019) of it to friends with gut problems who were getting no benefit from standard vitamin D.
It worked well for them in each case

Since ~2017 I also have been purchasing Micro D3 Nanoemulsion for inhaled Vitamin D experiments
   see further down this page details on nutrasal.com product

In March 2019 I also purchased PreventiX, Hi-Pro Emulsi-D3, Bio-Emulsion-D3, and Liquid Vitamin D3
They were added because
1) They had good Amazon reviews
2) Were likely to have a micro/nano size,
3) Seemed to have a > 1,000 IU per drop.
4) Were fairly low cost (per 5,000 IU)

I also have been getting some Vitamin D Nanoemulsion from Bio-Tech Pharmacal since ~2016.
They are making it for some Vitamin D clinical trials, and I have used it for inhaled tests.
Bio-Tech Pharmacal emulsion is not (as of 2019) being sold commercially.
Note: March 2019 Dried beans and peas in meal appear to decrease uptake of oil-based Vitamin D
If you often eat pulses when supplementing with Vitamin D, you might need to have a non-oil-based vitamin D, such as in the above picture

Multiple Sclerosis category listing has 404 items along with
  • 22 articles which are in both MS and Genetics categories
  • 12 articles which are in both MS and Vitamin D Receptor categories
  • 7 articles which are in both MS and Vitamin D Binding categories

Migraine Headaches associated with metal excess/deficiencies, perhaps MS as well

Headache has the following on metals and migraines
Compared blood levels of 25 people with migraines to 25 people without GreenMedInfo

Metal MigraineNo Migraine Migraine Ratio
Cadmium 0.36 ug0.09 ug 4X MORE if increase
Iron0.97 ug0.48 ug2X MORE if increase
Lead1.48 ug0.78 ug 2X MORE if increase
Magnesium10.6 ug34.5 ug 3.5X LESS if increase
Zinc *0.24 ug 5.77 ug 24X LESS if increase

 * Note: Zinc increases the activation of the Vitamin D Receptor, which allows more vitamin D into cells


  • Zinc somewhat reduced Migraine in RCT - Sept 2020

Zinc supplementation affects favorably the frequency of migraine attacks: a double-blind randomized placebo-controlled clinical trial https://doi.org/10.1186/s12937-020-00618-9 FREE PDF

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