Irish Acupuncturist and Nutritionist MIchael Cawley reversed 20 years of his MS symptoms with Coimbra Protocol.
He was then invited to San Paulo, Brazil by Dr.Cicero Coimbra MD (2017) and was added to list of Coimbra Protocol Practioners.
Upon clinical application of Coimbra Protocol he made several important discoveries
- Many MS patients became worse on high doses of Vitamin D3 that had halted and reversed his own illness.
- In large numbers of MS sufferer’s Vitamin D3 above 500 iu per kg of Vitamin D3 can worsen Multiple Sclerosis symptoms, while 400 - 500 iu per kg of body weight of Vitamin D can ease symptoms significantly. This worsening of symptoms is misdiagnosed as a multiple sclerosis “flare”, usually adding more D3 makes matters worse.
- He believes that smaller doses (16,000 IU to 18,000 IU) of the properly matched Vitamin D3 and Magnesium supplement can have life-transforming effects on a small number of people, who will only be made worse with higher doses.
- Vitamin D3 brand/form can determine whether Multiple Sclerosis responds to Vitamin D3. Clinical benefit can be determined by the oil the Vitamin D3 is combined with. He investigated multiple liquid and capsule brands of Vitamin D3 and recommends a select few that work the best.
- Magnesium can make MS symptoms worse when it interacts with toxic heavy metals. He believes that symptoms often misdiagnosed as an MS flare.
- Vitamin B2 can either improve or drastically worsen symptoms of Multiple Sclerosis. Worsening of symptoms are also often misdiagnosed as MS flare.
- He had not found the parathyroid Hormone level to be a reliable indicator for success of Vitamin D3.
- Note: He was taken off the list of Coimbra Protocol practitioners in May 2018 (no reason given).
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- He advocates Personalized Vitamin D3 method which encourages people to listen to how they feel on different D3 forms/doses, also pioneers use of several forms of D3 used simultaneously.
- He only recommends very specific brands/forms of Vitamin D3, Magnesium, Vitamin B2 , VItamin K2 which have proven themselves with MS cases.
In 18 months no calcium toxicity reported due to lower doses required to gain benefit, early cessation of Vitamin D3 supplementation if ionized calcium or serum calcium exceed highest reference range and use of pharma grade K2. www.menaquingold.com
- In May 2018 started a Facebook group which has become Personalized Vitamin D3 Therapy for MS With Michael Cawley
- Contact email cawleymjd at gmail.com, He does Skype appointments.
Comments by Henry Lahore, founder of VitaminDWiki after a video conference with Mike on March 25, 2019
Mike noticed fast reactions by MSers to different forms of Vitamin D
When he had MSers take 20,000 IU of vitamin D, within a day they would either
1) Feel a lot better
2) Feel no difference
3) Feel lots of pain
I have not heard of such fast and strong reactions to Vitamin D before, and suspect not everyone has such strong reactions.
I suspect much of the difference was in the improved gut-friendliness of vitamin D emulsions, etc.
He also found differences of benefits between suppliers of Vitamin K2-7 and Magnesium
He. like I, had been taking Life Extension Super K, but he found that Menaquin Gold (India) was able to dissolve his artery plaque, whereas Super K did not. He sent me a bottle. It appears that form is not on Amazon is out of stock on the web (March 2019).
He, like I, had found Magnesium Chloride to be pretty good. He also recommends Magceutics Magtein
I mentioned that Ultraviolet light provides MSers with even more benefit than Vitamin D alone. MSers getting the same blood level response from UV and oral vitamin D got significantly fewer relapses. I suspect there is more than vitamin D is generated in the skin from the sun/UV
You can make your own powerful UV lamp from two parts for $40 (Amazon (US)
I have been using that UV lamp ~weekly in the winter since 2012
Overview MS and vitamin D contains the following summary
Clinical interventions have shown that Vitamin D can prevent, treat, and even cure Multiple Sclerosis, at a tiny fraction of the cost of the drugs now used to treat it, and without side effects.
- Fact: Low Vitamin D results in higher risk of getting MS
Increase latitude leads to decreased Vitamin D, which leads to increased risk of MS
Dark skinned people are far more likely to get MS (dark skin people typically have low vitamin D)
Elderly (who typically have low vitamin D) are more likely to get MS
Is there increased risk in people who already have diseases associated with low vitamin D - TB, for example ? ? ?
Women typically have 3X increased MS risk then men (note: women typically have 20% lower levels of vitamin D than men)
Exception: women in very sunny climates and dark-skinned women have the same MS risk as men
Obese are 60% more likely to get MS
Smokers - smokers have lower level of vitamin D and have higher incidence of MS (also, smokers are difficult to cure of MS in Brazil)
MS recurrence is much higher in spring - the lowest time of the year for vitamin D
increase in clouds/rainfall (which reduces available Vitamin D) is associated with increased risk of MS (Scotland, Western Washington)
MS incidence has increased 70% in a decade while the incidence of vitamin D deficiency doubled
Less MS in those with outdoor occupations PDF file, not a web page
- Fact: MS uses up Vitamin D
- Fact: Lower vitamin D (due to MS using up Vitamin D while fighting the disease) results in many other health problems (such as broken bones), so depleted vitamin D levels must be restored.
- Fact: Vitamin D looks so promising for preventing and treating MS that there were 25 INTERVENTION clinical trials as of Feb 2014
- Fact: Vitamin D reduced the MS relapse rate far better than Fingolimod which is now used for that purpose.
- Note: Fingolimod costs $25,000/year while vitamin D, which works better and has no site effects is 1000 times less expensive.
- Fact: 98% of the genes affected by Interferon are also affected by Vitamin D
- Note: 1 week of Interferon = $4,700, 1 week of vitamin D 10,000X lower cost
- Fact: MS Doctors in Brazil recommending 40-100 ng/mL of Vitamin D
- Fact: Many MS forums are recommending vitamin D to treat MS, with some taking 5,000 to 10,000 IU daily
Observation: Risk of going from pre-MS to MS reduced 68 percent with 7100 IU vitamin D – RCT Dec 2012
- This is an observation instead of a fact - it has not yet been confirmed.
- Fact: VERY LARGE doses of vitamin D have CURED 2,000 people of MS in Brazil
- Controversy: UVB fron sunlight or UVB bulb may be BETTER than Vitamin D for reducing the risk of getting MS
- Hypothesis: In addition to Vitamin D there are many other photoproducts produced by UVB that may promote health.
Summary: lack of consensus on how much to prevent, treat, or cure MS.
- How much Vitamin D to prevent many diseases - such as MS
- How much Vitamin D is needed to treat MS? There is currently no agreement
The recommendations range from 40 to 100 ng - which can result of a dose ranging from 3,000 to 20,000 IU/day
- How Vitamin D is needed to Cure MS?: It appears that 20,000-140,000 IU daily may be needed to CURE the disease
You must be under the supervision of a doctor who knows what to watch for in your individual situation.
High doses of Vitamin D cannot be used as a monotherapy.
You will need to adjust the cofactors: Typically increasing Magnesium and Vitamin K2, and reducing Calcium intake.
Your doctor will monitor these and might increase your intake of Vitamins B2, C, as well as Omega-3
Multiple Sclerosis and (lots of) Vitamin D - book by patient on Coimbra protocol - Feb 2016
contains protocol description and list of Coimbra Facebook Groups
Vitamin D has treated Multiple Sclerosis for 16 years– Coimbra video April 2018
MS updates from Brazil
Table compares 4 High-dose vitamin D therapies 2 of which are Coimbra
- Vitamin D is the only dietary supplement which significantly benefits MS – JAMA April 2018
- Multiple Sclerosis treated when use high doses of vitamin D – meta-analysis May 2018
- Vitamin D has treated Multiple Sclerosis and autoimmune diseases for 16 years – Coimbra April 2018 includes great video in English
- Multiple Sclerosis – many reasons to believe Vitamin D can prevent and treat it – Feb 2018
- Multiple Sclerosis patients have 3X less Vitamin K2 in their blood – March 2018
- Multiple Sclerosis and Vitamin D – chapter and entire MS book - Nov 2017
- Multiple Sclerosis, Alzheimer’s and Parkinson’s need more than 30 ng of Vitamin D – review Nov 2017
- Fewer Multiple Sclerosis lesions when supplemented with Vitamin D – meta-analysis May 2017
- Doctor got multiple sclerosis, rejected then embraced Coimbra protocol for herself and patients – Jan 2017
- Guide for patients on high doses of Vitamin D – Coimbra 2017
Overview Gut and vitamin D contains gut-friendly information
Getting Vitamin D into your body has the following chart
Getting Vitamin D into your body also has the following
Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into bloodstream
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into bloodstream. Prescription only?
Bio-Tech might be useful – it is also water soluble
Vitamin D sprayed inside cheeks 2X more response (poor gut) – RCT Oct 2015
and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gut
|10||Injection: Vitamin D,|
or Calcidiol or Calcitriol
(skin patch/cream, vagina)
|6||Water soluble (Bio-Tech)||Normal||Normal|
perhaps activates VDR
(some goes into gut)
|3||Coconut oil based||Slow||Normal|
|2||Food (salmon etc.)||Slow||Normal|
|2||Olive oil based (majority)||Slow||Normal|
10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months
High-dose vitamin D massively changes the gut bionome
Cooked dried beans or peas (pulses) reduce update of Vitamin D, Vitamin K by half – March 2019
If confirmed, should not take oil-based vitamin D with a pulse meal
Stems cells might be one of the ways Vitamin D fights health problems
Perhaps high dose Vitamin D along with Magnesium etc. activates stem cells, which then repair the brain
Nanoemulsion Vitamin D may be a substantially better form was updated after talking with Cawley
There are a variety of Vitamin D emulsions on Amazon (US) as of 2019
Bio Emulsion Forte is what I started buying in 2012.
I have given out 3 bottles (as of 2019) of it to friends with gut problems who were getting no benefit from standard vitamin D.
It worked well for them in each case
Since ~2017 I also have been purchasing Micro D3 Nanoemulsion for inhaled Vitamin D experiments
In March 2019 I purchased PreventiX, Hi-Pro Emulsi-D3, Bio-Emulsion-D3, and Liquid Vitamin D3
They were selected because
1) They had good Amazon reviews
2) Were likely to have a micro/nano size,
3) Seemed to have a > 1,000 IU per drop.
4) Was fairly low cost (per 5,000 IU)
I have not even opened them yet
I also have been getting some Vitamin D Nanoemulsion from Bio-Tech Pharmacal since ~2016.
They are making it for some Vitamin D clinical trials, and I have used it for inhaled tests.
It is not (as of 2018) being sold commercially.
Note: March 2019 |Dried beans and peas appear to decrease concurrent uptake of oil-based Vitamin D
If you often eat pulses when supplementing with Vitamin D, you might need to have a non-oil-based vitamin D, such as in the above picture
Multiple Sclerosis category listing has
20 articles which are in both MS and Genetics categories 7 articles which are in both MS and Vitamin D Receptor categories 4 articles which are in both MS and Vitamin D Binding categories
Migraine Headaches associated with metal excess/deficiencies, perhaps MS as well
Compared blood levels of 25 people with migraines to 25 people without GreenMedInfo
Metal Migraine No Migraine Ratio Cadmium 0.36 ug 0.09 ug 4X MORE if decrease Iron 0.97 ug 0.48 ug 2X MORE if decrease Lead 1.48 ug 0.78 ug 2X MORE if decrease Magnesium 10.6 ug 34.5 ug 3.5X LESS if increase Zinc 0.24 ug 5.77 ug 24X LESS if increase
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