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Personalized Vitamin D treatment of Multiple Sclerosis - Michael Cawley

Irish Acupuncturist and Nutritionist MIchael Cawley reversed 20 years of his MS symptoms with Coimbra Protocol.

He was then invited to San Paulo, Brazil by Dr.Cicero Coimbra MD (2017) and was added to list of Coimbra Protocol Practioners.

Upon clinical application of Coimbra Protocol he made several important discoveries

  • Many MS patients became worse on high doses of Vitamin D3 that had halted and reversed his own illness.
  • In large numbers of MS sufferer’s Vitamin D3 above 500 iu per kg of Vitamin D3 can worsen Multiple Sclerosis symptoms, while 400 - 500 iu per kg of body weight of Vitamin D can ease symptoms significantly. This worsening of symptoms is misdiagnosed as a multiple sclerosis “flare”, usually adding more D3 makes matters worse.
  • He believes that smaller doses (16,000 IU to 18,000 IU) of the properly matched Vitamin D3 and Magnesium supplement can have life-transforming effects on a small number of people, who will only be made worse with higher doses.
  • Vitamin D3 brand/form can determine whether Multiple Sclerosis responds to Vitamin D3. Clinical benefit can be determined by the oil the Vitamin D3 is combined with. He investigated multiple liquid and capsule brands of Vitamin D3 and recommends a select few that work the best.
  • Magnesium can make MS symptoms worse when it interacts with toxic heavy metals. He believes that symptoms often misdiagnosed as an MS flare.
  • Vitamin B2 can either improve or drastically worsen symptoms of Multiple Sclerosis. Worsening of symptoms are also often misdiagnosed as MS flare.
  • He had not found the parathyroid Hormone level to be a reliable indicator for success of Vitamin D3.
  • Note: He was taken off the list of Coimbra Protocol practitioners in May 2018 (no reason given).

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  • He advocates Personalized Vitamin D3 method which encourages people to listen to how they feel on different D3 forms/doses, also pioneers use of several forms of D3 used simultaneously.
  • He only recommends very specific brands/forms of Vitamin D3, Magnesium, Vitamin B2 , VItamin K2 which have proven themselves with MS cases.

In 18 months no calcium toxicity reported due to lower doses required to gain benefit, early cessation of Vitamin D3 supplementation if ionized calcium or serum calcium exceed highest reference range and use of pharma grade K2. www.menaquingold.com

Comments by Henry Lahore, founder of VitaminDWiki after a video conference with Mike on March 25, 2019

Mike noticed fast reactions by MSers to different forms of Vitamin D
When he had MSers take 20,000 IU of vitamin D, within a day they would either
1) Feel a lot better
2) Feel no difference
3) Feel lots of pain
I have not heard of such fast and strong reactions to Vitamin D before, and suspect not everyone has such strong reactions.
I suspect much of the difference was in the improved gut-friendliness of vitamin D emulsions, etc.
He also found differences of benefits between suppliers of Vitamin K2-7 and Magnesium

He. like I, had been taking Life Extension Super K, but he found that Menaquin Gold (India) was able to dissolve his artery plaque, whereas Super K did not. He sent me a bottle. It appears that form is not on Amazon is out of stock on the web (March 2019).

He, like I, had found Magnesium Chloride to be pretty good. He also recommends Magceutics Magtein

I mentioned that Ultraviolet light provides MSers with even more benefit than Vitamin D alone. MSers getting the same blood level response from UV and oral vitamin D got significantly fewer relapses. I suspect there is more than vitamin D is generated in the skin from the sun/UV
You can make your own powerful UV lamp from two parts for $40 (Amazon (US)
I have been using that UV lamp ~weekly in the winter since 2012


See also Vitamin D

Overview MS and vitamin D contains the following summary

Clinical interventions have shown that Vitamin D can prevent, treat, and even cure Multiple Sclerosis, at a tiny fraction of the cost of the drugs now used to treat it, and without side effects.

Summary: lack of consensus on how much to prevent, treat, or cure MS.

  • How much Vitamin D to prevent many diseases - such as MS
  • How much Vitamin D is needed to treat MS? There is currently no agreement
       The recommendations range from 40 to 100 ng - which can result of a dose ranging from 3,000 to 20,000 IU/day
  • How Vitamin D is needed to Cure MS?: It appears that 20,000-140,000 IU daily may be needed to CURE the disease
       You must be under the supervision of a doctor who knows what to watch for in your individual situation.
       High doses of Vitamin D cannot be used as a monotherapy.
       You will need to adjust the cofactors: Typically increasing Magnesium and Vitamin K2, and reducing Calcium intake.
       Your doctor will monitor these and might increase your intake of Vitamins B2, C, as well as Omega-3


Multiple Sclerosis and (lots of) Vitamin D - book by patient on Coimbra protocol - Feb 2016
contains protocol description and list of Coimbra Facebook Groups

Vitamin D has treated Multiple Sclerosis for 16 years– Coimbra video April 2018
MS updates from Brazil
Table compares 4 High-dose vitamin D therapies 2 of which are Coimbra


Overview Gut and vitamin D contains gut-friendly information

Gut-friendly, Sublingual, injection, topical, UV, sunshine

Getting Vitamin D into your body has the following chart
Image

Getting Vitamin D into your body also has the following

If poorly functioning gut

Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into bloodstream
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into bloodstream. Prescription only?
Bio-Tech might be usefulit is also water soluble
Vitamin D sprayed inside cheeks 2X more response (poor gut) – RCT Oct 2015
    and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following

Guesses of Vitamin D response if poor gut

Bio FormSpeedDuration
10Injection: Vitamin D,
or Calcidiol or Calcitriol
D - Slow
C -Fast
Long
10 Sun/UVSlowLong
10Topical
(skin patch/cream, vagina)
SlowNormal
9?Inhaled (future)FastNormal
8Bio-D-Mulsion ForteNormalNormal
6Water soluble (Bio-Tech)NormalNormal
5Nanoemulsion
perhaps activates VDR
NormalNormal
4Sublingual/spray
(some goes into gut)
FastNormal
3Coconut oil basedSlowNormal
2Food (salmon etc.)SlowNormal
2Olive oil based (majority)SlowNormal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months

---

High-dose vitamin D massively changes the gut bionome
Cooked dried beans or peas (pulses) reduce update of Vitamin D, Vitamin K by half – March 2019
   If confirmed, should not take oil-based vitamin D with a pulse meal
Stems cells might be one of the ways Vitamin D fights health problems
Perhaps high dose Vitamin D along with Magnesium etc. activates stem cells, which then repair the brain

Nanoemulsion Vitamin D may be a substantially better form was updated after talking with Cawley

Bought 6 kinds of Vitamin D Emulsion - March 2019

There are a variety of Vitamin D emulsions on Amazon (US) as of 2019
Bio Emulsion Forte is what I started buying in 2012.
I have given out 3 bottles (as of 2019) of it to friends with gut problems who were getting no benefit from standard vitamin D.
It worked well for them in each case

Since ~2017 I also have been purchasing Micro D3 Nanoemulsion for inhaled Vitamin D experiments
   see further down this page details on nutrasal.com product

In March 2019 I also purchased PreventiX, Hi-Pro Emulsi-D3, Bio-Emulsion-D3, and Liquid Vitamin D3
Image
They were added because
1) They had good Amazon reviews
2) Were likely to have a micro/nano size,
3) Seemed to have a > 1,000 IU per drop.
4) Were fairly low cost (per 5,000 IU)

I also have been getting some Vitamin D Nanoemulsion from Bio-Tech Pharmacal since ~2016.
They are making it for some Vitamin D clinical trials, and I have used it for inhaled tests.
Bio-Tech Pharmacal emulsion is not (as of 2019) being sold commercially.
Note: March 2019 Dried beans and peas in meal appear to decrease uptake of oil-based Vitamin D
If you often eat pulses when supplementing with Vitamin D, you might need to have a non-oil-based vitamin D, such as in the above picture

Multiple Sclerosis category listing has 330 items along with
  • 22 articles which are in both MS and Genetics categories
  • 9 articles which are in both MS and Vitamin D Receptor categories
  • 5 articles which are in both MS and Vitamin D Binding categories

Migraine Headaches associated with metal excess/deficiencies, perhaps MS as well

Headache has the following on metals and migraines

Compared blood levels of 25 people with migraines to 25 people without GreenMedInfo

Metal MigraineNo Migraine Migraine Ratio
Cadmium 0.36 ug0.09 ug 4X MORE if increase
Iron0.97 ug0.48 ug2X MORE if increase
Lead1.48 ug0.78 ug 2X MORE if increase
Magnesium10.6 ug34.5 ug 3.5X LESS if increase
Zinc0.24 ug 5.77 ug 24X LESS if increase

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