J Crohns Colitis. 2012 Mar;6(2):182-8. Epub 2011 Sep 25.
Suibhne TN, Cox G, Healy M, O'Morain C, O'Sullivan M.
Department of Clinical Medicine, Trinity College Dublin, Adelaide & Meath Hospital, Dublin, Ireland.
BACKGROUND AND AIMS:
Vitamin D deficiency impacts on bone health and has potential new roles in inflammation. We aimed to determine the prevalence of and risk factors for vitamin D deficiency and to explore vitamin D supplement usage in patients with Crohn's disease (CD) in an outpatient setting, compared with controls.
Serum 25-hydroxyvitamin D 25(OH)D concentrations were measured by radioimmunoassay in 151 participants, comprising 81 CD patients and 70 age-, sex- and socio-economic status-matched healthy controls. Levels of 25(OH)D <50 nmol/L were classed as deficient. Data on vitamin supplement usage were recorded for all participants at interview.
Vitamin D deficiency was common in patients with CD (63%) and significantly higher in winter than summer (68% v 50%; p<0.001, ?(2)).
Notably, the deficiency rate remained high even in summer (50%). On regression analysis, 25(OH)D levels were inversely associated with winter season. Disease-specific factors for lower serum 25(OH)D levels were longer disease duration and smoking. Overall, 43% of patients reported using a vitamin D-containing supplement, primarily at low dosages (200-400 IU/d); however, this level of supplement did not prevent deficiency. For the majority of CD patients, 25(OH)D remained below optimal levels proposed to confer bone and immune health benefits.
Vitamin D deficiency was common in patients with CD and associated with longstanding disease, smoking and winter. While over 40% of patients used a vitamin D-containing supplement, the dosages were inadequate to prevent deficiency. Appropriate vitamin D screening and supplementation should be considered in the context of health promotion of outpatients with CD.
Copyright © 2011 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.
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No surprise since Croh’s disease reduces the vitamin D absorbed from the gut with conventional supplements
- UV lamp
- Sublinqual vitamin D – or perhaps drops
Note: vitamin K2 may be important as well
- All items in category Gut and Vitamin D
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