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IBD helped by vitamin D but reluctant to state who helped, in what form, and how much – review Nov 2014

Vitamin D Therapy in Inflammatory Bowel Diseases who, in what form, and how much?

Journal of Crohn's and Colitis DOI: http://dx.doi.org/10.1093/ecco-jcc/jju004 First published online: 26 November 2014
Tibor Hlavaty, Anna Krajcovicova, Juraj Payer
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Background: The north–south geographical gradient of inflammatory bowel disease (IBD) prevalence, the epidemiology of IBD and its genetic association with vitamin D receptor polymorphisms, and results in animal models suggest that vitamin D plays an important role in the pathogenesis of IBD.

Aims: The purpose of this review was to critically appraise the effectiveness and safety of vitamin D therapy in patients with IBD.

Methods: MEDLINE, Scopus and Google Scholar were searched from inception to 20th May 2014 using the terms ‘Crohn’s disease’, ‘ulcerative colitis’ and ‘vitamin D’.

Results: Vitamin D deficiency is common in patients with IBD. Limited clinical data suggest an association between low vitamin D concentration and increased disease activity in both ulcerative colitis (UC) and Crohn’s disease (CD). To date, only two small open label trials and one randomised controlled trial have shown a positive effect of vitamin D supplementation on disease activity in patients with CD but not UC.
An optimal vitamin D supplementation protocol for patients with IBD remains undetermined, but targeting serum 25(OH)D levels between 30 and 50 ng/ml appears safe and may have benefits for IBD disease activity. Depending on the baseline vitamin D serum concentration, ileal involvement in CD, body mass index and, perhaps, smoking status, daily vitamin D doses between 1800–10,000 IU/day are probably necessary.

Conclusion: Increasing pre-clinical and clinical evidence suggests a role for vitamin D deficiency in the development and severity of IBD. The possible therapeutic role of vitamin D in patients with IBD merits continued investigation.

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Attached files

ID Name Comment Uploaded Size Downloads
4722 IBD Dec 2014.pdf admin 13 Dec, 2014 1.52 Mb 1644
4721 IBD and Vitamin D.jpg admin 13 Dec, 2014 72.53 Kb 6479