- Vitamin D: Dosing, levels, form, and route of administration: Does one approach fit all?
- Study says vitamin D needed varies with
- Vitamin D IU needed varies with
- VitaminDWiki - Personalized treatment of Vitamin D
- VitaminDWiki - Some diseases reduce vitamin D getting to blood or cells
- VitaminDWiki - Overview Gut and vitamin D contains gut-friendly information
- TOP articles in Forms of Vitamin D:
Vitamin D: Dosing, levels, form, and route of administration: Does one approach fit all?
Reviews in Endocrine and Metabolic Disorders (2021) 22:1201-1218 https://doi.org/10.1007/s11154-021-09693-7
John P. Bilezikian • Anna Maria Formenti • Robert A. Adler • Neil Binkley • Roger Bouillon Marise Lazaretti-Castro • Claudio Marcocci • Nicola Napoli8 • Rene Rizzoli9 • Andrea Giustina2 Division of Endocrinology, Escola Paulista de Medicina - Universidade Federal de Sao Paulo (EPM-UNIFESP), Sao Paulo, Brazil
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
Unit of Endocrinology and Diabetes, Campus Bio-Medico University of Rome, Rome, Italy
Service of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
- Andrea Giustina giu stina.andrea @ hsr. it
Department of Medicine, Endocrinology Division, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA
Institute of Endocrine and Metabolic Sciences, San Raffaele, Vita-Salute University and IRCCS Hospital, Milano, Italy
McGuire Veterans Affairs Medical Center and Virginia Commonwealth University School of Medicine, Richmond, VA, USA
University of Wisconsin, Madison, WI, USA
Laboratory of Clinical and Experimental Endocrinology,Department of chronic diseases, metabolism and ageing,Leuven, KU, Belgium
The 4th International Conference on Controversies in Vitamin D was held as a virtual meeting in September, 2020, gathering together leading international scientific and medical experts in vitamin D. Since vitamin D has a crucial role in skeletal and extra-skeletal systems, the aim of the Conference was to discuss improved management of vitamin D dosing, therapeutic levels and form or route of administration in the general population and in different clinical conditions. A tailored approach, based on the specific mechanisms underlying vitamin D deficiency in different diseases that were discussed, was recommended. Specifically, in comparison to healthy populations, higher levels of vitamin D and greater amounts of vitamin D were deemed necessary in osteoporosis, diabetes mellitus, obesity (particularly after bariatric surgery), and in those treated with glucocorticoids. Emerging and still open issues were related to target vitamin D levels and the role of vitamin D supplementation in COVID-19 since low vitamin D may predispose to SARS-CoV-2 infection and to worse COVID-19 outcomes. Finally, whereas oral daily cholecalciferol appears to be the preferred choice for vitamin D supplementation in the general population, and in most clinical conditions, active vitamin D analogs may be indicated in patients with hypoparathyroidism and severe kidney and liver insufficiency. Parenteral vitamin D administration could be helpful in malabsorption syndromes or in states of vitamin D resistance. Specific guidelines for desired levels of vitamin D should be tailored to the different conditions affecting vitamin D metabolism with the goal to define disease-specific normative values.
Download the PDF from VitaminDWiki
Study says vitamin D needed varies with
Obesity
Bariatric surgery
Exogenous and endogenous glucocorticoid excess
Gastrointestinal diseases
rimaryHyperparathyroidism
Osteoporosis
Chronic kidney disease
Diabetes mellitus
Malignancy (Cancer)
Infections
Multiple sclerosis
COVID-19
Daily dosing vs weekly vs monthly
Vitamin D IU needed varies with
VitaminDWiki - Personalized treatment of Vitamin D
VitaminDWiki - Some diseases reduce vitamin D getting to blood or cells
Some diseases restrict vitamin D by changing gene activation,
by one or more of the following
- Restrict conversion of light into vitamin D in the skin
- Restrict oral absorption in the gut
- Restrict semi-activation in the liver
- Restrict free semi-activated vitamin D from getting to the kidneys
- Restrict full activation in the kidneys
- Restrict semi and fully activation in the cells
- Restrict activated Vitamin D from entering cell mitochondria (VDR)
- Destroy the vitamin D before it gets to the cells
Some diseases restrict vitamin D without changing genes
- The disease just uses/consumes the vitamin D
- The disease upsets the gut, which reduces bioavailability of oral form
- unless a gut-friendly form is used
References
- COVID changes 100 vitamin D-related genes in the lungs
- Reasons for low response to vitamin D
- Genetics category has
346 items along with related searches - The risk of 44 diseases at least double with poor VDR as of Oct 2019
VitaminDWiki - Overview Gut and vitamin D contains gut-friendly information
Gut-friendly, Sublingual, injection, topical, UV, sunshineGetting Vitamin D into your blood and cells has the following chart
Getting Vitamin D into your blood and cells also has the following
If poorly functioning gut
Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into the bloodstream
Fat-soluble Vitamins go thru the slow lymph system
you can make your own sublingual by dissolving Vitamin D in water or use nano form
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into the bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into the bloodstream. Prescription-only?
Bio-Tech might be useful – it is also water-soluble
Vitamin D sprayed inside cheeks (buccal spray) - several studies
and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gutBio Form Speed Duration 10 Injection ($$$)
or Calcidiol or CalcitriolD - Slow
C -FastLong 10 Sun/UVB Slow Long 10 Topical
(skin patch/cream, vagina)Slow
Fast nanoNormal 9 Nanoemulsion -mucosal
perhaps activates VDRFast Normal 9? Inhaled (future) Fast Normal 8 Bio-D-Mulsion Forte Normal Normal 6 Water soluble (Bio-Tech) Normal Normal 4 Sublingual/spray
(some goes into gut)Fast Normal 3 Coconut oil based Slow Normal 2 Food (salmon etc.) Slow Normal 2 Olive oil based (majority) Slow Normal 10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months
TOP articles in Forms of Vitamin D:
- Fat-soluble Vitamins go thru the slow lymph system
- Olive oil problem with Vitamin D (again) - Nov 2023
- Vitamin D that dissolves in mouth helps those having poor response due to poor guts, HSCT etc.- June 2023
- Vitamin D: not one size, type, form, route for all - Jan 2022
- Nanoemulsion Vitamin D faster and better (paywall) – RCT Dec 2021
- Psoriasis paradigm shift – use topicals, like Vitamin D – Aug 2021
- Nanoemulsion Vitamin D is faster and better - many studies
- Vitamin D – food fortification around the world, types of microencapsulation – Feb 2020
- Nanoemulsion vitamin D is again found to be the best liquid form (for rats in this case) – June 2019
- Bioavailability of nanoemulsion formulations of Vitamin D3 – Nov 2019
- Topical Vitamin D provides more benefits than oral sometimes - many studies
- Vitamin D nanoemulsion etc. for fortification, pills, injections, topical and cancer – July 2019
- Vitamin D nanoemulsion corrected deficiency and improved bones in 1 week (high dose in rats) – Jan 2019
- Nanoemulsion Vitamin D may be a substantially better form
- Inhaled vitamin D help lungs - many studies
- Vitamin D sprayed inside cheeks (buccal spray) - several studies
- Getting Vitamin D into your blood and cells
- Topical vitamin D raised blood level to 38 ng (used Aloe Vera gel) – RCT March 2014
- Spray vitamin D inside cheek in case of emergency - Nov 2012
Vitamin D: not one size, type, form, route for all - Jan 2022Printer Friendly Follow this page for updates7570 visitors, last modified 09 Mar, 2024, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 16938 A,pimnt needed varies.jpg admin 30 Jan, 2022 122.05 Kb 779 16937 Vitamin D - Dosing, levels, form, and route of administration - Does one approach fit all_compressed.pdf admin 30 Jan, 2022 416.06 Kb 728