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Crohn’s Disease risk increased 3 X if inadequate vitamin D level (another form is needed) – Oct 2017

The Association of Vitamin D Status with Disease Activity in a Cohort of Crohn’s Disease Patients in Canada

Nutrients 2017, 9(10), 1112; doi:10.3390/nu9101112, Published: 12 October 2017

VitaminDWiki

Poor guts need different forms of vitamin D

Guesses of Vitamin D response if poor gut

Bio FormSpeedDuration
10Injection ($$$)
or Calcidiol or Calcitriol
D - Slow
C -Fast
Long
10 Sun/UVBSlowLong
10Topical
(skin patch/cream, vagina)
Slow
Fast nano
Normal
9Nanoemulsion -mucosal
perhaps activates VDR
FastNormal
9?Inhaled (future)FastNormal
8Bio-D-Mulsion ForteNormalNormal
6Water soluble (Bio-Tech)NormalNormal
4Sublingual/spray
(some goes into gut)
FastNormal
3Coconut oil basedSlowNormal
2Food (salmon etc.)SlowNormal
2Olive oil based (majority)SlowNormal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months


Getting Vitamin D into your body has the following chart

Image


Gut category listing contains the following

176 items in GUT category - see also Overview Gut and vitamin D, See also Microbiome category listing has 27 items along with related searches.


 Download the PDF from VitaminDWiki

Dania Alrefai 1, Jennifer Jones 2, Wael El-Matary 3, Susan J. Whiting 1OrcID, Abdulrahman Aljebreen 4, Naghmeh Mirhosseini 5OrcID and Hassan Vatanparast 1,* OrcID
1 College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5C9, Canada
2 Division of Digestive Care & Endoscopy, Department of Community Health and Epidemiology, Dalhousie University, Truro, NS B2N 5E3, Canada
3 College of Medicine, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
4 College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia
5 Pure North S’Energy Foundation, Calgary, AB T2R 0C5, Canada
*Author to whom correspondence should be addressed.

We determined the association between vitamin D status as 25hydroxyvitamin D [25(OH)D] and disease activity in a cohort of 201 Crohn’s Disease (CD) patients in Saskatoon, Canada over three years. The association between high-sensitivity C-reactive protein (hs-CRP) and 25(OH)D and several disease predictors were evaluated by the generalized estimating equation (GEE) over three time-point measurements. A GEE binary logistic regression test was used to evaluate the association between vitamin D status and the Harvey-Bradshaw Index (HBI). The deficient vitamin D group (≤29 nmol/L) had significantly higher mean hs-CRP levels compared with the three other categories of vitamin D status (p < 0.05). CRP was significantly lower in all of the other groups compared with the vitamin D-deficient group, which had Coef. = 12.8 units lower (95% CI −19.8, −5.8), Coef. 7.85 units (95% CI −14.9, −0.7), Coef. 9.87 units (95% CI −17.6, −2.0) for the vitamin D insufficient, adequate, and optimal groups, respectively. The vitamin D status was associated with the HBI active disease category.
However, the difference in the odds ratio compared with the reference category of deficient vitamin D category was only significant in the insufficient category (odds ratio = 3.45, p = 0.03, 95% CI 1.0, 10.8). Vitamin D status was inversely associated with indicators of disease activity in Crohn’s disease, particularly with the objective measures of inflammation.


Created by admin. Last Modification: Thursday October 12, 2017 13:56:42 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
8537 Crohn’s 3 X more likely if vitamin D insufficient.pdf PDF 2017 admin 12 Oct, 2017 13:40 281.74 Kb 547
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