Journal of Crohn's and Colitis DOI: http://dx.doi.org/10.1093/ecco-jcc/jju004 First published online: 26 November 2014
Tibor Hlavaty, Anna Krajcovicova, Juraj Payer
Background: The north–south geographical gradient of inflammatory bowel disease (IBD) prevalence, the epidemiology of IBD and its genetic association with vitamin D receptor polymorphisms, and results in animal models suggest that vitamin D plays an important role in the pathogenesis of IBD.
Aims: The purpose of this review was to critically appraise the effectiveness and safety of vitamin D therapy in patients with IBD.
Methods: MEDLINE, Scopus and Google Scholar were searched from inception to 20th May 2014 using the terms ‘Crohn’s disease’, ‘ulcerative colitis’ and ‘vitamin D’.
Results: Vitamin D deficiency is common in patients with IBD. Limited clinical data suggest an association between low vitamin D concentration and increased disease activity in both ulcerative colitis (UC) and Crohn’s disease (CD). To date, only two small open label trials and one randomised controlled trial have shown a positive effect of vitamin D supplementation on disease activity in patients with CD but not UC.
An optimal vitamin D supplementation protocol for patients with IBD remains undetermined, but targeting serum 25(OH)D levels between 30 and 50 ng/ml appears safe and may have benefits for IBD disease activity. Depending on the baseline vitamin D serum concentration, ileal involvement in CD, body mass index and, perhaps, smoking status, daily vitamin D doses between 1800–10,000 IU/day are probably necessary.
Conclusion: Increasing pre-clinical and clinical evidence suggests a role for vitamin D deficiency in the development and severity of IBD. The possible therapeutic role of vitamin D in patients with IBD merits continued investigation.
- Overview Gut and vitamin D
- "inflammatory bowel disease" OR "inflammatory bowel symptom" 351 as ofJan 2016
- At least one company has a vitamin D form designed for poor guts
The TOP articles in Gut and Vitamin D are listed here:
- Gut Microbiota: improved by Vitamin D – narrative review – July 2021
- Immunologic Effects of Vitamin D on Human Health and Disease - Holick July 2020
- Topical Vitamin D provides more benefits than oral sometimes - many studies
- Gut is helped by Vitamin D – Sept 2017
- Gut problems associated with low vitamin D – invited review Dec 2015
- Vitamin D sprayed inside cheeks (buccal spray) - several studies
- Gut microbiome massively changed by weekly vitamin D – July 2015
- Vitamin D and Inflammatory Bowel Disease – review April 2015
- Inflammatory diseases: review of vitamin D, with many tables – May 2014
- Inflammatory bowel diseases are helped by vitamin D – commissioned review Nov 2013