Complementary Therapies in Medicine, https://doi.org/10.1016/j.ctim.2019.08.023
Seyed Mostafa Parizadeh, Reza Jafarzadeh-Esfehani, Seyed Mahdi Hassanian, Ali Mottaghi-Moghaddam, Anahita Ghazaghi, Maryam Ghandehari, Mohadese Alizade-Noghani, Majid Khazaei, Majid Ghayour-Mobarhan, Gordon A. Ferns, Seyed Mohammad Reza Parizadeh, Amir Avan
Overview Gut and vitamin D has the following summary
- Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
- Celiac disease has a strong genetic component.
- Most, but not all, people with celiac disease have a gene variant.
- An adequate level vitamin D seems to decrease the probability of getting celiac disease.
- Celiac disease causes poor absorption of nutrients such as vitamin D.
- Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
- The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
- Review in Nov 2013 found that Vitamin D helped
Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
- All items in category gut and vitamin D
Overview Gut and vitamin D contains gut-friendly informationGut-friendly, Sublingual, injection, topical, UV, sunshine
Getting Vitamin D into your body has the following chart
Getting Vitamin D into your body also has the following
Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into bloodstream
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into bloodstream. Prescription only?
Bio-Tech might be useful – it is also water soluble
Vitamin D sprayed inside cheeks 2X more response (poor gut) – RCT Oct 2015
and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gut
Bio Form Speed Duration 10 Injection: Vitamin D,
or Calcidiol or Calcitriol
D - Slow
Long 10 Sun/UV Slow Long 10 Topical
(skin patch/cream, vagina)
Normal 9? Inhaled (future) Fast Normal 8 Bio-D-Mulsion Forte Normal Normal 6 Water soluble (Bio-Tech) Normal Normal 5 Nanoemulsion
perhaps activates VDR
Normal Normal 4 Sublingual/spray
(some goes into gut)
Fast Normal 3 Coconut oil based Slow Normal 2 Food (salmon etc.) Slow Normal 2 Olive oil based (majority) Slow Normal
10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months
Gut category listing contains the following
163 items in GUT category - see also Overview Gut and vitamin D,
- "Ulcerative Colitis" OR UC 839 items Jan 2020
- "celiac disease" OR CD 1830 items July 2019
- "inflammatory bowel disease" OR "inflammatory bowel symptom" 1630 items as of Jan 2020
- Crohn's 1230 items as of Feb 2019
- Gut-Friendly forms of vitamin D
such as: bio-emulsion, topical, spray, sublingual, inhaled, injection . .
- Vitamin D deficiency is a major concern in general population as well as in IBD patients.
- The main focus of most of present clinical studies are on the inflammatory state rather than evaluation clinical outcomes.
- The exact dose of vitamin D supplementation in IBD patients has not been studied systematically in clinical trials which requires further studies with greater sample size with more emphasizes on every vitamin D sources especially the sun exposure.
Inflammatory bowel disease (IBD) Is a chronic Immune-medlated Inflammatory disorder of the gastrointestinal tract consisting two principal categories, ulcerative colitis (UC) and Crohn's disease (CD). The precise etiology of IBD remains unknown. Vitamin D Is an Important mlcronutrlent that plays a critical biological role In various processes In human tissues. However, the relationship between disruption of the gut mlcroblota and the development of IBD Is unclear. Some studies suggest that IBD Is the cause of disrupted gut mlcroblota while others propose that gut mlcroblota Itself can lead to development of IBD. Regardless of this complexity, It has emerged that vitamin D Is an Immunoregulatory factor that plays a significant role In the pathogenesis of IBD by affecting the gut mlcroblome and the Inflammatory response. It has been reported that 38.1% of CD patients and 31.6% of UC patients suffer from vitamin D deficiency (VDD). In this review, we aimed to evaluate the association between VDD and IBD, summarizing recent clinical studies examining the effect of low vitamin D and the role of vitamin D supplementation on IBD clinical outcomes.Inflammatory Bowel Disease Inflammation and Vitamin D – scores of studies and trials – Aug 2019
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