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Inflammatory Bowel Disease Inflammation and Vitamin D – scores of studies and trials – Aug 2019

Vitamin D in inflammatory bowel disease: from biology to clinical implications

Complementary Therapies in Medicine, https://doi.org/10.1016/j.ctim.2019.08.023
Seyed Mostafa Parizadeh, Reza Jafarzadeh-Esfehani, Seyed Mahdi Hassanian, Ali Mottaghi-Moghaddam, Anahita Ghazaghi, Maryam Ghandehari, Mohadese Alizade-Noghani, Majid Khazaei, Majid Ghayour-Mobarhan, Gordon A. Ferns, Seyed Mohammad Reza Parizadeh, Amir Avan

VitaminDWiki

Most of the trials used
1) too little D3,
2) non gut-friendly D3, or
3) Vitamin D2

Overview Gut and vitamin D has the following summary

  • Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
  • Celiac disease has a strong genetic component.
    • Most, but not all, people with celiac disease have a gene variant.
    • An adequate level vitamin D seems to decrease the probability of getting celiac disease.
    • Celiac disease causes poor absorption of nutrients such as vitamin D.
    • Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
    • The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
  • Review in Nov 2013 found that Vitamin D helped
    Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
  • All items in category gut and vitamin D 163 items

Overview Gut and vitamin D contains gut-friendly information

Gut-friendly, Sublingual, injection, topical, UV, sunshine

Getting Vitamin D into your body has the following chart
Image

Getting Vitamin D into your body also has the following

If poorly functioning gut

Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into bloodstream
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into bloodstream. Prescription only?
Bio-Tech might be usefulit is also water soluble
Vitamin D sprayed inside cheeks 2X more response (poor gut) – RCT Oct 2015
    and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gut

Bio FormSpeedDuration
10Injection: Vitamin D,
or Calcidiol or Calcitriol
D - Slow
C -Fast
Long
10 Sun/UVSlowLong
10Topical
(skin patch/cream, vagina)
Slow
Fast nano
Normal
9?Inhaled (future)FastNormal
8Bio-D-Mulsion ForteNormalNormal
6Water soluble (Bio-Tech)NormalNormal
5Nanoemulsion
perhaps activates VDR
NormalNormal
4Sublingual/spray
(some goes into gut)
FastNormal
3Coconut oil basedSlowNormal
2Food (salmon etc.)SlowNormal
2Olive oil based (majority)SlowNormal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months

Gut category listing contains the following

163 items in GUT category - see also Overview Gut and vitamin D,


Inflammatory Bowel Disease – proposed Vitamin D protocol – Oct 2019

 Download the PDF from Sci-Hub via VitaminDWiki

Highlights:

  • Vitamin D deficiency is a major concern in general population as well as in IBD patients.
  • The main focus of most of present clinical studies are on the inflammatory state rather than evaluation clinical outcomes.
  • The exact dose of vitamin D supplementation in IBD patients has not been studied systematically in clinical trials which requires further studies with greater sample size with more emphasizes on every vitamin D sources especially the sun exposure.

Inflammatory bowel disease (IBD) Is a chronic Immune-medlated Inflammatory disorder of the gastrointestinal tract consisting two principal categories, ulcerative colitis (UC) and Crohn's disease (CD). The precise etiology of IBD remains unknown. Vitamin D Is an Important mlcronutrlent that plays a critical biological role In various processes In human tissues. However, the relationship between disruption of the gut mlcroblota and the development of IBD Is unclear. Some studies suggest that IBD Is the cause of disrupted gut mlcroblota while others propose that gut mlcroblota Itself can lead to development of IBD. Regardless of this complexity, It has emerged that vitamin D Is an Immunoregulatory factor that plays a significant role In the pathogenesis of IBD by affecting the gut mlcroblome and the Inflammatory response. It has been reported that 38.1% of CD patients and 31.6% of UC patients suffer from vitamin D deficiency (VDD). In this review, we aimed to evaluate the association between VDD and IBD, summarizing recent clinical studies examining the effect of low vitamin D and the role of vitamin D supplementation on IBD clinical outcomes.


Created by admin. Last Modification: Tuesday October 29, 2019 15:15:02 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
12649 IBD Sci-Hub.pdf PDF 2019 admin 16 Sep, 2019 09:36 276.91 Kb 113
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