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IBS – 6 out of 7 studies shows Vitamin D helps, still want more studies – Jan 2018

Vitamin D status in irritable bowel syndrome and the impact of supplementation on symptoms: what do we know and what do we need to know?

European Journal of Clinical Nutrition (2018), doi:10.1038/s41430-017-0064-z
Claire E. Williams, Elizabeth A. Williams & Bernard M. Corfe

 Download the PDF from Sci-Hub.tw via VitaminDWiki

Background
Low vitamin D status is associated with risk of colorectal cancer and has been implicated in inflammatory bowel disease. Irritable bowel syndrome (IBS) is a chronic, relapsing, functional bowel disorder. A nascent literature suggests a role for vitamin D in IBS, but this has not been collated or critiqued. To date, seven studies have been published: four observational studies and three randomised controlled trials (RCTs). All observational studies reported that a substantial proportion of the IBS population was vitamin D deficient. Two intervention studies reported improvement in IBS symptom severity scores and quality of life (QoL) with vitamin D supplementation.
There are limited data around the role of vitamin D in IBS.

Conclusions
The available evidence suggests that low vitamin D status is common among the IBS population and merits assessment and rectification for general health reasons alone. An inverse correlation between serum vitamin D and IBS symptom severity is suggested and vitamin D interventions may benefit symptoms. However, the available RCTs do not provide strong, generalizable evidence; larger and adequately powered interventions are needed to establish a case for therapeutic application of vitamin D in IBS.

Created by admin. Last Modification: Thursday January 25, 2018 22:35:13 UTC by admin. (Version 6)

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ID Name Comment Uploaded Size Downloads
9249 IBS Vit D.pdf PDF 2018 admin 25 Jan, 2018 16:59 367.52 Kb 136
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