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Vitamin D fights IBD, no consensus yet on dose size and type – Aug 2022

The use of vitamin D for patients with inflammatory bowel diseases

Int J Vitam Nutr Res. 2022 Aug 26. doi: 10.1024/0300-9831/a000764   PDF is behind paywall
Júlia Novaes Matias 1 , Vinícius Marinho Lima 1 , Giovanna Soares Nutels 1 , Lucas Fornari Laurindo 1 , Sandra Maria Barbalho 1 2 , Ricardo de Alvares Goulart 2 , Adriano Cressoni Araújo 1 2 , Rodrigo Buzinaro Suzuki 1 3 , Elen Landgraf Guiguer 1 2

As Vitamin D (VD) plays an essential role in Inflammatory Bowel Diseases, this systematic review aimed to update the participation of this vitamin in the prevention or remission of these diseases. This review has included studies in MEDLINE-PubMed, EMBASE, and Cochrane databases. The authors have followed PRISMA (Preferred Reporting Items for a Systematic Review and Meta-analysis) guidelines. According to the inclusion and exclusion criteria, twenty-two randomized clinical trials were selected. In all, 1,209 patients were included in this systematic review: 1034 received only VD and 175 received VD in combination with calcium.

The average doses of VD supplementation were from oral 400 IU daily to 10,000 IU per kilogram of body weight. Single injection of 300,000 IU of VD was also used. Several studies have shown the crucial role that VD plays in the therapeutic approach of IBD due to its effects on the immune system. It effectively decreased inflammatory cytokines such as TNF-α and IFN-γ (p<0.05) and provided a reduction in disease activity assessed through different scores such as Crohn's Disease Activity Index (CDAI) (p<0.05) and Ulcerative Colitis Disease Activity Index (UCDAI) (p<0.05).
Unfortunately, the available clinical trials do not have standardization of doses and routes of administration. Existing meta-analyses are biased because they compare studies using different doses or treatments in combination with different drugs or supplements such as calcium. Even though VD has crucial effects on inflammatory processes, there is still a need for standardized studies to establish how the supplementation should be performed and the doses to be administered.

VitaminDWiki pages with IBD in title (28 as of Sept 2022)

This list is automatically updated

Items found: 29
Title Modified
Vitamin D interactions with poor gut (Celiac, IBD, and Bariatric surgery) – Feb 2023 23 Feb, 2023
IBD treated in children by Vitamin D, especially if use more than 2,000 IU daily for 12 weeks – meta-analysis – Sept 2022 14 Sep, 2022
Vitamin D fights IBD, no consensus yet on dose size and type – Aug 2022 26 Aug, 2022
IBD is treated by Vitamin D and other Nutraceuticals – June 2022 23 Jun, 2022
IBD (Colitis, Crohn’s) was active 6X more often if low vitamin D – June 2015 30 May, 2022
IBD in children might be associated with low sun exposure 28 Feb, 2022
IBD strongly associated with low Vitamin D – Jan 2022 09 Jan, 2022
IBD and Crohn's patients need Vitamin D, even to increase drug efficacy (Vedolizumab) June 2021 29 Jun, 2021
IBD and UV dissertation - 2019 10 Sep, 2019
Vitamin D appears to fight Diabetes, MS, RA, Lupus, IBD, Hepatitis, Cancer, Psoriasis, Food allergy, etc – June 2019 17 Jul, 2019
IBD in Finland – 3X increase in 15 years, more prevalent further from equator – Nov 2012 14 May, 2019
Common cold incidence reduced by two thirds (500 IU for IBD with low vitamin D) – RCT Jan 2019 04 Jan, 2019
Risks of Colorectal Cancer, IBD, etc slightly increased if poor Vitamin D Receptor – Aug 2018 09 Dec, 2018
IBD relapse rate reduced by low Vitamin D - meta-analysis Nov 2018 27 Nov, 2018
Higher Vitamin D increased the benefit of anti-TNF- α drug used for IBD by 2.6 times – Jan 2017 31 Jan, 2017
IBD in Canadian children increasing 7% per year - Nov 2016 22 Nov, 2016
IBD UC and CD at risk of being vitamin D deficient – May 2011 04 Nov, 2016
IBD deficiencies of Iron and Vitamin D (and new Iron types) – June 2016 20 Jun, 2016
IBD helped by vitamin D but reluctant to state who helped, in what form, and how much – review Nov 2014 08 Jan, 2016
IBD more likely in areas with low UV ( and thus low vitamin D) – June 2014 05 Dec, 2015
Gut problems more likely if low vitamin D (IBD: 1.6, UC: 2.3) – meta-analysis Aug 2015 31 Oct, 2015
IBD (Collitis, Chron’s) was active 6X more often if low vitamin D – June 2015 03 Oct, 2015
Crohn’s disease deficient in vitamin K – IBD deficient in vitamins K and D – April 2011 17 Feb, 2015
Appears that IBD lowers vitamin D, which increases risk of cancer by 80 percent – Oct 2013 09 Jul, 2014
IBD surgery 5X more likely for non-caucasians with low vitamin D – Oct 2012 03 Nov, 2012
IBD and Crohn but not Colitis associated with low vitamin D – May 2011 05 Jun, 2012
IBD colorectal Cancer and vitamin D – Jan 2011 14 Mar, 2012
Dogs – like humans – with IBD were low on vitamin D – July 2011 14 Mar, 2012
IBD less costly when treated with vitamin D3 compared to D2 – Jan 2012 12 Jan, 2012

VitaminDWiki pages with IBS in title (different than IBD, 11 as of Aug 2022)

This list is automatically updated

Items found: 11

VitaminDWiki - Overview Gut and vitamin D contains

  • Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
  • Celiac disease has a strong genetic component.
    • Most, but not all, people with celiac disease have a gene variant.
    • An adequate level vitamin D seems to decrease the probability of getting celiac disease.
    • Celiac disease causes poor absorption of nutrients such as vitamin D.
    • Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
    • The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
  • Review in Nov 2013 found that Vitamin D helped
    Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
  • All items in category gut and vitamin D 191 items

VitaminDWiki - Overview Gut and vitamin D contains gut-friendly information

Gut-friendly, Sublingual, injection, topical, UV, sunshine

Getting Vitamin D into your body has the following chart

Getting Vitamin D into your body also has the following
If poorly functioning gut
Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into bloodstream
   you can make your own sublinqual by dissovling Vitamin D in water or using nanoemulsion form
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into bloodstream. Prescription only?
Bio-Tech might be usefulit is also water soluble
Vitamin D sprayed inside cheeks (buccal spray) - several studies
    and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gut

Bio FormSpeedDuration
10Injection ($$$)
or Calcidiol or Calcitriol
D - Slow
C -Fast
10 Sun/UVBSlowLong
(skin patch/cream, vagina)
Fast nano
9Nanoemulsion -mucosal
perhaps activates VDR
9?Inhaled (future)FastNormal
8Bio-D-Mulsion ForteNormalNormal
6Water soluble (Bio-Tech)NormalNormal
(some goes into gut)
3Coconut oil basedSlowNormal
2Food (salmon etc.)SlowNormal
2Olive oil based (majority)SlowNormal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months

Created by admin. Last Modification: Wednesday September 14, 2022 20:17:22 GMT-0000 by admin. (Version 7)