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Inflammatory bowel diseases are associated with Vitamin D etc. – meta-meta-analysis - April 2019

Environmental Risk Factors for Inflammatory Bowel Diseases: an Umbrella Review of Meta-analyses.

Gastroenterology. 2019 Apr 20. pii: S0016-5085(19)36709-5. doi: 10.1053/j.gastro.2019.04.016. Piovani D1, Danese S1, Peyrin-Biroulet L2, Nikolopoulos GK3, Lytras T4, Bonovas S5.

VitaminDWiki

Overview Gut and vitamin D has the following summary

  • Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
  • Celiac disease has a strong genetic component.
    • Most, but not all, people with celiac disease have a gene variant.
    • An adequate level vitamin D seems to decrease the probability of getting celiac disease.
    • Celiac disease causes poor absorption of nutrients such as vitamin D.
    • Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
    • The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
  • Review in Nov 2013 found that Vitamin D helped
    Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
  • All items in category gut and vitamin D 169 items


Overview Gut and vitamin D contains gut-friendly information

Gut-friendly, Sublingual, injection, topical, UV, sunshine

Getting Vitamin D into your body has the following chart
Image

Getting Vitamin D into your body also has the following

If poorly functioning gut

Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into bloodstream
   you can make your own sublinqual by dissovling Vitamin D in water or using nanoemulsion form
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into bloodstream. Prescription only?
Bio-Tech might be usefulit is also water soluble
Vitamin D sprayed inside cheeks 2X more response (poor gut) – RCT Oct 2015
    and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gut

Bio FormSpeedDuration
10Injection ($$$)
or Calcidiol or Calcitriol
D - Slow
C -Fast
Long
10 Sun/UVBSlowLong
10Topical
(skin patch/cream, vagina)
Slow
Fast nano
Normal
9Nanoemulsion -mucosal
perhaps activates VDR
FastNormal
9?Inhaled (future)FastNormal
8Bio-D-Mulsion ForteNormalNormal
6Water soluble (Bio-Tech)NormalNormal
4Sublingual/spray
(some goes into gut)
FastNormal
3Coconut oil basedSlowNormal
2Food (salmon etc.)SlowNormal
2Olive oil based (majority)SlowNormal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months


Gut category listing contains the following

169 items in GUT category - see also Overview Gut and vitamin D,

The Meta-analysis of Gut and Vitamin D 

BACKGROUND & AIMS:
Multiple environmental factors have been associated with development of inflammatory bowel diseases (IBD). We performed an umbrella review of meta-analyses to summarize available epidemiologic evidence and assess its credibility.

METHODS:
We systematically identified and appraised meta-analyses of observational studies examining environmental factors and risk of IBD (Crohn's disease CD or ulcerative colitis UC). For each meta-analysis we considered the random-effects estimate, its 95% CI, the estimates of heterogeneity and small-study effects, and graded the evidence according to prespecified criteria. Methodologic quality was assessed using AMSTAR 2.

RESULTS:
We examined 183 estimates in 53 meta-analyses of 71 environmental factors related to lifestyles and hygiene, surgeries, drug exposures, diet, microorganisms, and vaccinations.
We identified 9 factors that increase risk of IBD:

  • smoking (CD),
  • urban living (CD and IBD),
  • appendectomy (CD),
  • tonsillectomy (CD),
  • antibiotic exposure (IBD),
  • oral contraceptive use (IBD),
  • consumption of soft drinks (UC),
  • vitamin D deficiency (IBD), and
  • non-Helicobacter pylori-like enterohepatic Helicobacter species (IBD).

We identified 7 factors that reduce risk of IBD:

  • physical activity (CD),
  • breastfeeding (IBD),
  • bed sharing (CD),
  • tea consumption (UC),
  • high levels of folate (IBD),
  • high levels of vitamin D (CD),
  • Helicobacter pylori infection (CD, UC, and IBD).

Epidemiologic evidence for all these associations were of high to moderate strength; we identified another 11 factors associated with increased risk and 16 factors associated with reduced risk with weak credibility. Methodologic quality varied considerably among meta-analyses. Several associations were based on findings from retrospective studies, so it is not possible to determine if these are effects of IBD or results of recall bias.

CONCLUSIONS:
In an umbrella review of meta-analyses, we found varying levels of evidence for associations of different environmental factors with risk of IBD. High-quality prospective studies with analyses of samples from patients with recent diagnoses of IBD are needed to determine whether these factors cause or are results of IBD, and their pathogenic mechanisms.


Created by admin. Last Modification: Thursday April 25, 2019 14:00:56 GMT-0000 by admin. (Version 1)
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