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Immune system and vitamin D, with emphasis on Inflammatory Bowel Disease – May 2022


The Role of Vitamin D in Immune System and Inflammatory Bowel Disease

Journal of Inflammation Research Volume 2022:15 Pages 3167—3185 https://doi.org/10.2147/JIR.S363840
Wu Z , Liu D, Deng F Zengrong Wu,1,2 Deliang Liu,1,2 Feihong Deng1,2 dfh411 at csu.edu.cn
1Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, People’s Republic of China;
2Research Center of Digestive Disease, Central South University, Changsha, Hunan, 410011, People’s Republic of China

PDF Table of Contents

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Chart: Immune system and Vitamin D

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Chart Intestines, Vitamin D and immune system

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Inflammatory bowel disease (IBD) is a nonspecific inflammatory disease that includes ulcerative colitis (UC) and Crohn’s disease (CD). The pathogenesis of IBD is not fully understood but is most reported associated with immune dysregulation, dysbacteriosis, genetic susceptibility, and environmental risk factors. Vitamin D is an essential nutrient for the human body, and it not only regulates bone metabolism but also the immune system, the intestinal microbiota and barrier. Vitamin D insufficiency is common in IBD patients, and the abnormal low levels of vitamin D are highly correlated with disease activity, treatment response, and risk of relapse of IBD. Accumulating evidence supports the protective role of vitamin D in IBD through regulating the adaptive and innate immunity, maintaining the intestinal barrier and balancing the gut microbiota. This report aims to provide a broad overview of the role vitamin D in the immune system, especially in the pathogenesis and treatment of IBD, and its possible role in predicting relapse.
 Download the PDF from VitaminDWiki


VitaminDWiki pages with IBD or IBS in title (25 as of May 2022)

This list is automatically updated

Items found: 37
Title Modified
IBS helped by vitamin D (virtually ignoring dose size, type and duration) – meta-analysis June 2022 09 Jul, 2022
IBD is treated by Vitamin D and other Nutraceuticals – June 2022 23 Jun, 2022
IBD (Colitis, Crohn’s) was active 6X more often if low vitamin D – June 2015 30 May, 2022
IBD in children might be associated with low sun exposure 28 Feb, 2022
IBD strongly associated with low Vitamin D – Jan 2022 09 Jan, 2022
IBS not helped by daily 3,000 IU Vitamin D (but non-daily and gut-friendly help) – RCT July 2021 31 Jul, 2021
IBD and Crohn's patients need Vitamin D, even to increase drug efficacy (Vedolizumab) June 2021 29 Jun, 2021
IBS diarrhea treated by weekly 50,000 IU of Vitamin D – RCT March 2020 25 Mar, 2020
IBD and UV dissertation - 2019 10 Sep, 2019
Vitamin D appears to fight Diabetes, MS, RA, Lupus, IBD, Hepatitis, Cancer, Psoriasis, Food allergy, etc – June 2019 17 Jul, 2019
IBD in Finland – 3X increase in 15 years, more prevalent further from equator – Nov 2012 14 May, 2019
Common cold incidence reduced by two thirds (500 IU for IBD with low vitamin D) – RCT Jan 2019 04 Jan, 2019
Risks of Colorectal Cancer, IBD, etc slightly increased if poor Vitamin D Receptor – Aug 2018 09 Dec, 2018
IBS (1 in 5 youths) strongly associated with low vitamin D – Dec 2018 01 Dec, 2018
IBD relapse rate reduced by low Vitamin D - meta-analysis Nov 2018 27 Nov, 2018
IBS quality of life improved by vitamin D (50,000 IU every two weeks) – RCT May 2016 14 Mar, 2018
IBS - many indications that Vitamin D will help - more research needed - March 2018 14 Mar, 2018
IBS – 6 out of 7 studies shows Vitamin D helps, still want more studies – Jan 2018 25 Jan, 2018
Higher Vitamin D increased the benefit of anti-TNF- α drug used for IBD by 2.6 times – Jan 2017 31 Jan, 2017
IBD in Canadian children increasing 7% per year - Nov 2016 22 Nov, 2016
70 percent of people with IBS had symptoms relieved with high dose vitamin D – 2012 04 Nov, 2016
IBD UC and CD at risk of being vitamin D deficient – May 2011 04 Nov, 2016
IBS – 82 percent had low vitamin D, 3,000 IU spray helped a lot – RCT Dec 2015 25 Aug, 2016
Sleep, Vitamin D, Vitamin B-12, IBS, Fibromyalgia - Gominak March 2015 27 Jul, 2016
IBD deficiencies of Iron and Vitamin D (and new Iron types) – June 2016 20 Jun, 2016
IBS quality of life improved by vitamin D (50,000 IU weekly) – RCT May 2016 17 May, 2016
IBD helped by vitamin D but reluctant to state who helped, in what form, and how much – review Nov 2014 08 Jan, 2016
IBD more likely in areas with low UV ( and thus low vitamin D) – June 2014 05 Dec, 2015
Gut problems more likely if low vitamin D (IBD: 1.6, UC: 2.3) – meta-analysis Aug 2015 31 Oct, 2015
IBD (Collitis, Chron’s) was active 6X more often if low vitamin D – June 2015 03 Oct, 2015
Crohn’s disease deficient in vitamin K – IBD deficient in vitamins K and D – April 2011 17 Feb, 2015
Appears that IBD lowers vitamin D, which increases risk of cancer by 80 percent – Oct 2013 09 Jul, 2014
IBD surgery 5X more likely for non-caucasians with low vitamin D – Oct 2012 03 Nov, 2012
IBD and Crohn but not Colitis associated with low vitamin D – May 2011 05 Jun, 2012
IBD colorectal Cancer and vitamin D – Jan 2011 14 Mar, 2012
Dogs – like humans – with IBD were low on vitamin D – July 2011 14 Mar, 2012
IBD less costly when treated with vitamin D3 compared to D2 – Jan 2012 12 Jan, 2012

VitaminDWiki pages with CROHN in (35 as ofMay 2022)

This list is automatically updated

Items found: 38
Title Modified
IBD (Colitis, Crohn’s) was active 6X more often if low vitamin D – June 2015 30 May, 2022
IBD and Crohn's patients need Vitamin D, even to increase drug efficacy (Vedolizumab) June 2021 29 Jun, 2021
Crohn’s disease helped when vitamin D level raised above 30 ng – RCT Feb 2015 26 Mar, 2021
Crohn’s Disease reduced for a year by 7 weeks of high dose Vitamin D – RCT March 2021 26 Mar, 2021
Crohn's Disease patients normalizing their Vitamin D levels decreased risk of surgery by 44 percent – Aug 2013 09 Feb, 2021
Crohn's Disease 4X less likely to reoccur after surgery if good level of vitamin D – Feb 2021 09 Feb, 2021
Crohn’s Disease is associated with poor Vitamin D Receptor (many solutions) – April 2020 29 Apr, 2020
Crohn's disease associated with 7.6X deactivation of Vitamin D receptor – July 2015 12 Nov, 2019
Crohn’s Disease associated with lower Vitamin D - meta-analysis Sept 2019 28 Sep, 2019
Crohn’s Disease Activity predicted by vitamin D plus 2 additional blood tests – Dec 2018 07 May, 2019
Inflammatory Bowel Disease in children is associated with low Vitamin D, Iron (also low Zinc for Crohn’s) – Aug 2018 28 Aug, 2018
Gut bacteria of Crohn's disease patients improved by Vitamin D – March 2018 15 May, 2018
Crohn's patients with Vitamin D less than 30 ng were 1.8 X more likely to be readmitted within 1 year – April 2017 13 Mar, 2018
Crohn's disease in black children is worse in 6 ways – Dec 2015 10 Dec, 2017
Crohn's Disease flares 20 percent more likely if poor Vitamin D Binding Protein – Oct 2016 09 Nov, 2017
Crohn’s Disease risk increased 3 X if inadequate vitamin D level (another form is needed) – Oct 2017 12 Oct, 2017
Crohn's Disease relapse rate of 3 in 8 with 1,0000 IU vs 0 in 12 with 10,000 IU of Vitamin D – RCT Feb 2017 16 Jul, 2017
Crohn's Disease relapse rate of 3 in 8 with 1,000 IU vs 0 in 12 with 10,000 IU of Vitamin D – RCT Feb 2017 15 Jul, 2017
Crohn's disease treated by 2000 IU Vitamin D - RCT June 2015 31 Jan, 2017
Crohn’s disease associated with vitamin D and latitude – meta-analysis Dec 2015 11 Dec, 2016
Boron and Granulomas (TB, Rheumatoid arthritis, Crohn's, Rheumatic Fever etc.) - 2015 14 Nov, 2016
Crohn’s disease associated with low vitamin D, unless in remission (22 vs 28ng)– Dec 2015 30 Jul, 2016
Is vitamin D supplementation a viable treatment for Crohn's disease – Nov 2015 18 Nov, 2015
Infliximab reduction of inflammation (Crohn’s) greatly aided by Vitamin D – Sept 2015 12 Sep, 2015
Crohn's disease treated by Vitamin D - RCT June 2015 07 Aug, 2015
Crohn’s disease deficient in vitamin K – IBD deficient in vitamins K and D – April 2011 17 Feb, 2015
Crohn’s helped by 5000 IU vitamin D – April 2013 17 Feb, 2015
Crohn’s Disease – strange things such as no change of vitamin D levels with season – Dec 2014 09 Dec, 2014
Surgery for Crohn's disease 2X less likely if managed to raise vitamin D above 30 ng – May 2013 06 May, 2014
Active Crohn's disease is associated with low vitamin D levels – Feb 2013 14 Feb, 2013
About 40 percent more likely to get Crohn’s Disease or UC if have low vitamin D – March 2012 03 Nov, 2012
More than half those with Crohn’s disease have less than 20ng of vitamin D – March 2012 03 Nov, 2012
Even 800 IU vitamin D improved Crohn’s disease bone density – June 2012 03 Jul, 2012
Crohn's disease kids are 2X more likely to have low vitamin D, intervention helps – April 2012 12 Jun, 2012
IBD and Crohn but not Colitis associated with low vitamin D – May 2011 05 Jun, 2012
Crohn’s Disease strongly associated with low vitamin D in South Asians – March 2012 29 Mar, 2012
Extra Vitamin D needed for Crohns 14 Mar, 2012
Crohn’s relapse reduced from 29% to 13% by taking 1200 IU of D3 – May 2010 04 Apr, 2011

VitaminDWiki - Overview Gut and vitamin D contains

  • Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
  • Celiac disease has a strong genetic component.
    • Most, but not all, people with celiac disease have a gene variant.
    • An adequate level vitamin D seems to decrease the probability of getting celiac disease.
    • Celiac disease causes poor absorption of nutrients such as vitamin D.
    • Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
    • The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
  • Review in Nov 2013 found that Vitamin D helped
    Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
  • All items in category gut and vitamin D 182 items

Along with gut-friendly information


VitaminDWiki - Gut category contains

182 items in GUT category - see also Overview Gut and vitamin D, See also Microbiome category listing has 27 items along with related searches.

VitaminDWiki - Immunity category contains

233 items in Immunity category

    see also

Virus category listing has 1076 items along with related searches

Overview Influenza and vitamin D
Vitamin D helps both the innate and adaptive immune systems fight COVID-19 – Jan 2022
Vitamin D aids the clearing out of old cells (autophagy) – many studies
600,000 IU of Vitamin D (total) allowed previously weak immune systems to fight off a virus antigen - Nov 2020
Search for treg OR "t-cell" in VitaminDWiki 1440 items as of Jan 2020
141 VitaminDWiki pages contained "infection" in title (June 2021)
Search VitaminDWik for BACTERIA in title 25 items as of Aug 2019
Vitamin D and the Immune System – chapter Aug 2019
7X less risk of influenza if Vitamin D levels higher than 30 ng – Oct 2017
Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
Vitamin D improves T Cell immunity – RCT Feb 2016
Immune system - great 11-minute animated video - Aug 2021 nothing about Vitamin D
13 titles in VitaminDWiki contained INNATE or ADAPTIVE as of July 2021
Increasing publications on vitamin D and Infection
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39 studies are in both Immunity and Virus categories

Note: Gut-Friendly Vitamin D is far better for those with gut problems


Note: A time-release vitamin D would probably be good for gut problems - but do not know of a supplier as of May 2022


VitaminDWiki pages with Colitis in (15 as of May 2022)

This list is automatically updated

Items found: 17
Title Modified
Ulcerative Colitis treated 4X better when Vitamin D was added – Meta-Analysis – July 2022 01 Aug, 2022
IBD (Colitis, Crohn’s) was active 6X more often if low vitamin D – June 2015 30 May, 2022
Ulcerative Colitis and Vitamin D studies 03 Jun, 2021
Ulcerative Colitis significantly reduced by 480,000 IU loading dose of nano Vitamin D – RCT July 2019 21 Sep, 2019
Ulcerative Colitis (new) associated with lower free and bioavailable Vitamin D, but not total – Feb 2019 10 May, 2019
Ulcerative Colitis – half have poor level of Vitamin D Receptor vs only one in ten normally – June 2017 01 Apr, 2019
Ulcerative Colitis much worse if low vitamin D – March 2019 23 Mar, 2019
Turmeric stopped Ulcerative Colitis – RCT Feb 2019 03 Mar, 2019
Ulcerative Colitis inflammation treated by weekly vitamin D (40,000 IU) – July 2018 21 Dec, 2018
Colitis treated by activated vitamin D getting into the colon via emulsion (mice) – July 2018 24 Jul, 2018
Ulcerative colitis treated by injection of 300,000 IU of vitamin D – RCT July 2016 29 Apr, 2017
Ulcerative Colitis relapse 25 percent more likely if vitamin D level is lower than 35 ng – June 2016 18 Jan, 2017
Those with Ulcerative colitis and low vitamin D were 3.3X more likely to have anemia – Oct 2013 18 Jan, 2017
Ulcerative colitis associated with both low Vitamin D and poor Vitamin D Receptors – Oct 2016 24 Nov, 2016
IBD and Crohn but not Colitis associated with low vitamin D – May 2011 05 Jun, 2012
Vitamin D as a therapy for colitis: A systematic review – May 2012 05 Jun, 2012
Colitis associated with low level of vitamin D in mice – April 2010 07 Jul, 2010

Note: My spouse has very successfully used a nanoemulsion vitamin D to treat her colitis

She had severe attacks of ulcerative colitis many times a year for many decades
Adding oral vitamin D did not appear to help
Previously we had great success applying vitamin D directly to a problem
   gums, warts, burns, abrasions, etc.
We evolved ways to get vitamin d directly to this problem
Vitamin D powder added to water helped some when a teaspoon of it was inserted into the rectum
Adding salt to the water helped
100,0000 IU of nanoemulsion also was good
Ended up using 200,000 IU of nanoemulsion vitamin D in 1 pint of water with a "pinch" of - using about a tablespoon at a time
Similar attack frequency, but far less intense.
The problem goes away after 3 nightly applications


Created by admin. Last Modification: Monday May 30, 2022 16:28:23 GMT-0000 by admin. (Version 11)

Attached files

ID Name Comment Uploaded Size Downloads
17688 Intestine immunity.jpg admin 29 May, 2022 19:00 93.09 Kb 51
17687 Innate and adaptive.jpg admin 29 May, 2022 18:59 41.33 Kb 33
17686 ToC IBD.jpg admin 29 May, 2022 18:59 45.42 Kb 40
17685 Immune system IBD_CompressPdf.pdf PDF 2022 admin 29 May, 2022 18:58 493.21 Kb 16
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