Deficiencies of vitamin D in patients with intestinal malabsorption syndromes: Think in and outside of the gut
Journal of Digestive Diseases, DOI: 10.1111/1751-2980.12283
Samantha Margulies1, Divya Kurian1, Mark S Elliott2 andZhiyong Han2,*
There is a considerable high prevalence of vitamin D deficiency, which is defined by the serum level of 25-hydroxyvitamin D 25(OH)D lower than 20 ng/ml, in all populations of the world. Unfortunately, the prevalence of vitamin D deficiency in patients with intestinal malabsorption syndromes, including
- cystic fibrosis (CF),
- celiac disease (CD),
- short bowel syndrome, and
- inflammatory bowel disease (IBD),
is higher than that in the general population, indicating the presence of disease-specific causative factors.
In this review, we aim to present clinical findings to highlight the roles of insufficient sunlight exposure and inflammation in the development of vitamin D deficiency in patients with intestinal malabsorption syndromes.
Also, we aim to present experimental evidence that supports a role of vitamin D deficiency in the pathogenesis of IBD.
Finally, we review clinical intervention strategies that aim to normalize vitamin D status in and/or even improve the conditions of patients and discuss certain issues that need to be addressed in future research.
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