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Celiac Disease associated with deficiencies of Zinc etc – July 2019

Micronutrient Deficiencies Are Common in Contemporary Celiac Disease Despite Lack of Overt Malabsorption Symptoms

Mayo Clinic Proceesings DOI: https://doi.org/10.1016/j.mayocp.2018.11.036 |
Adam C. Bledsoe, MDa, Katherine S. King, MSb, Joseph J. Larson, BSb, Melissa Snyder, PhDc, Imad Absah, MDd, Rok Seon Choung, MD, PhDa, Joseph A. Murray, MDa,e,∗'Correspondence information about the author MD Joseph A. Murray

VitaminDWiki

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Overview Gut and vitamin D contains the following summary

  • Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
  • Celiac disease has a strong genetic component.
    • Most, but not all, people with celiac disease have a gene variant.
    • An adequate level vitamin D seems to decrease the probability of getting celiac disease.
    • Celiac disease causes poor absorption of nutrients such as vitamin D.
    • Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
    • The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
  • Review in Nov 2013 found that Vitamin D helped
  • Many intervention clinical trials for vitamin D to prevent or treat Gut problems (93 trials listed as of Jan 2017)
  • All items in category gut and vitamin D 141 items

Gut category listing contains the following

141 items in GUT category - see also Overview Gut and vitamin D,
  • Headache has the following information on Zinc
    Metal MigraineNo Migraine Ratio
    +Zinc0.24 ug 5.77 ug 24X LESS Migraine if increase Zinc

Zinc and Vitamin D category listing has 31 items

The Vitamin D Receptor contains 2 Zinc molecules.
Less Vitamin D in the blood will get to the tissues if low Zinc
Zinc is also needed to use Omega-3

 Download the PDF from VitaminDWiki

Plot of data by Grassroots Health
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Objective: To evaluate micronutrient deficiencies in a contemporary cohort of adult patients with newly diagnosed celiac disease (CD).

Patients and Methods
This is a retrospective study of prospective adults newly diagnosed with CD from January 1, 2000, through October 31, 2014, at Mayo Clinic. Micronutrient data were collected for tissue transglutaminase IgA, zinc, 25-hydroxy vitamin D, ferritin, albumin, copper, vitamin B12, and serum folate. Data were analyzed for absolute number of deficiencies and associations with age, sex, body mass index, presenting symptoms, and tissue transglutaminase IgA; each deficiency was assessed using logistic regression. Deficiencies were compared with age- and sex-matched controls from the National Health and Nutrition Examination Survey.

Results
In total, 309 patients with CD (196 women and 113 men; mean age, 46.1±15.1 years; mean body mass index, 25.9 kg/m2) were included. Weight loss was seen in only 25.2% (78/309) of patients. Zinc was deficient in 59.4% (126/212) of patients with CD compared with 33.2% (205/618) of controls (P<.001). Albumin was low in 19.7% (24/122) compared with 1.1% of controls (P<.001). Copper was low in 6.4% (13/204) compared with 2.1% (13/618) of controls (P=.003). Vitamin B12 was low in 5.3% (13/244) compared with 1.8% (11/618) of controls (P=.004). Folate was low in 3.6% (6/159) compared with 0.3% (2/618) of controls (P=.002). 25-Hydroxy vitamin D was low in 19.0% (44/213) compared with 18% (111/618) of controls (P=.72). Ferritin was low in 30.8% (66/214) of patients; no NHANES controls were available for comparison for ferritin.

Conclusion
Micronutrient deficiencies remain common in adults with CD despite increased nonclassic presentation. This study provides support for micronutrient assessment at the time of CD diagnosis.


Mercola July 2019

Zinc deficiency linked with gluten sensitivity

Created by admin. Last Modification: Saturday July 13, 2019 14:34:05 GMT-0000 by admin. (Version 8)

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ID Name Comment Uploaded Size Downloads
12293 Micronutreint celiac GRH.jpg admin 10 Jul, 2019 13:48 76.33 Kb 31
12292 micronutrient celiac.pdf PDF 2019 admin 10 Jul, 2019 13:46 175.11 Kb 7
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