Clinical Gastroenterology and Hepatology; V 11, Issue 12 , Pages 1631-1635, Dec 2013
Lillias H. Maguire, Mingyang Song , Lisa E. Strate , Edward L. Giovannucci , Andrew T. Chan
Background & Aims: Recent studies have shown geographic and seasonal variations in hospital admissions for diverticulitis. Because this variation parallels differences in ultraviolet light exposure, the most important contributor to vitamin D status, we examined the association of prediagnostic serum levels of vitamin D with diverticulitis.
Methods: Among patients within the Partners Healthcare System who had blood drawn and serum levels of 25-hydroxyvitamin D (25-[OH]D) measured, from 1993 through 2012, we identified
- 9116 patients with uncomplicated diverticulosis and
- 922 patients who developed diverticulitis that required hospitalization.
We used multivariate logistic regression to estimate relative risks and 95% confidence intervals to compare serum 25(OH)D levels between these groups.
Results: Patients with uncomplicated diverticulosis had significantly higher mean prediagnostic serum levels of 25(OH)D (29.1 ng/mL) than patients with diverticulitis who required hospitalization (25.3 ng/mL; P < .0001).
Compared with patients in the lowest quintile of 25(OH)D, the multivariate-adjusted relative risk for diverticulitis hospitalization was 0.49 (95% confidence interval, 0.38–0.62; P for trend < .0001) among patients in the highest quintile of 25(OH)D level.
Compared with patients with uncomplicated diverticulosis, the mean level of 25(OH)D was significantly lower for patients with
- acute diverticulitis without other sequelae (25.9 ng/mL; P < .0001; n = 594), for patients with diverticulitis with
- abscess (25.8 ng/mL; P = .0095; n = 124), for patients with
- diverticulitis requiring emergent laparotomy (22.7 ng/mL; P = .002; n = 65), and for patients with
- recurrent diverticulitis (23.5 ng/mL; P < .0001; n = 139).
Conclusions: Among patients with diverticulosis, higher prediagnostic levels of 25(OH)D are associated significantly with a lower risk of diverticulitis. These data indicate that vitamin D deficiency could be involved in the pathogenesis of diverticulitis.
PDF is attached at the bottom of this page
Note: this study identifies an association. It could easily be that the pathway is diverticulitis ==> Inflammation ==> consumes vitamin D ==> lowers the levels
- Search VitaminDWiki for diverticulitis 10 items as of Jan 2019
- Muscle inflammation 17X more probable if vitamin D deficient – Feb 2013
- Vitamin D decrease during inflammation is probably due to interferons - Oct 2012
- Hypothesis – vitamin D will decrease chronic inflammation and fatigue – Oct 2010
- Inflammatory bowel diseases are helped by vitamin D – commissioned review Nov 2013
- Gut doctors becoming aware of importance of vitamin D – May 2012
- People with gut problems are low on vitamin D
- Overview Gut and vitamin D - has a section on gui-friendly forms Vitamin D
- Bio-emulsified drops doubled vitamin D levels – Dec 2010 designed for people with poorly functioning guts
Other possibilities, which apparently do not need the gut, include vitamin D spray and sublingual vitamin D miro-tabs
- Piglets helped a lot with 40,000 IU on day 1, provided they did not have diarrhea – Aug 2013 piglets with poor guts make poor use of vitamin D, just like humans
- Association of geographic and seasonal variation with diverticulitis admissions Jan 2015
diverticulitis somewhat more likely in those regions with lower ambient UV light (less sun)
doi: 10.1001/jamasurg.2014.2049, free PDF online