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Diverticulitis less likely AND less severe if high level of vitamin D – Dec 2013

Higher Serum Levels of Vitamin D Are Associated With a Reduced Risk of Diverticulitis

Clinical Gastroenterology and Hepatology; V 11, Issue 12 , Pages 1631-1635, Dec 2013
Lillias H. Maguire, Mingyang Song , Lisa E. Strate , Edward L. Giovannucci , Andrew T. Chan

Background & Aims: Recent studies have shown geographic and seasonal variations in hospital admissions for diverticulitis. Because this variation parallels differences in ultraviolet light exposure, the most important contributor to vitamin D status, we examined the association of prediagnostic serum levels of vitamin D with diverticulitis.

Methods: Among patients within the Partners Healthcare System who had blood drawn and serum levels of 25-hydroxyvitamin D (25-[OH]D) measured, from 1993 through 2012, we identified

  • 9116 patients with uncomplicated diverticulosis and
  • 922 patients who developed diverticulitis that required hospitalization.

We used multivariate logistic regression to estimate relative risks and 95% confidence intervals to compare serum 25(OH)D levels between these groups.

Results: Patients with uncomplicated diverticulosis had significantly higher mean prediagnostic serum levels of 25(OH)D (29.1 ng/mL) than patients with diverticulitis who required hospitalization (25.3 ng/mL; P < .0001).
Compared with patients in the lowest quintile of 25(OH)D, the multivariate-adjusted relative risk for diverticulitis hospitalization was 0.49 (95% confidence interval, 0.38–0.62; P for trend < .0001) among patients in the highest quintile of 25(OH)D level.
Compared with patients with uncomplicated diverticulosis, the mean level of 25(OH)D was significantly lower for patients with

  • acute diverticulitis without other sequelae (25.9 ng/mL; P < .0001; n = 594), for patients with diverticulitis with
  • abscess (25.8 ng/mL; P = .0095; n = 124), for patients with
  • diverticulitis requiring emergent laparotomy (22.7 ng/mL; P = .002; n = 65), and for patients with
  • recurrent diverticulitis (23.5 ng/mL; P < .0001; n = 139).

Conclusions: Among patients with diverticulosis, higher prediagnostic levels of 25(OH)D are associated significantly with a lower risk of diverticulitis. These data indicate that vitamin D deficiency could be involved in the pathogenesis of diverticulitis.

PDF is attached at the bottom of this page
Note: this study identifies an association. It could easily be that the pathway is diverticulitis ==> Inflammation ==> consumes vitamin D ==> lowers the levels

See also VitaminDWiki

See also PubMed

  • Association of geographic and seasonal variation with diverticulitis admissions Jan 2015
    diverticulitis somewhat more likely in those regions with lower ambient UV light (less sun)
    doi: 10.1001/jamasurg.2014.2049, free PDF online

Attached files

ID Name Comment Uploaded Size Downloads
3341 Diverticulitis.pdf PDF - 2013 admin 01 Dec, 2013 16:40 127.76 Kb 887
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