Risk Factors for Vitamin D, Zinc, and Selenium Deficiencies in Korean Patients with Inflammatory Bowel Disease.
Gut Liver. 2017 May 15;11(3):363-369. doi: 10.5009/gnl16333.
Han YM1,2, Yoon H3, Lim S3, Sung MK4, Shin CM3, Park YS3, Kim N1,3, Lee DH1,3, Kim JS1,2.
- Zinc and Vitamin D category listing has
40 items along with related searches
Map from the Zinc category pages suggests that IBD Zinc deficiency is not constant around the world
Note: This 2017 study was from Korea, where they appear to have little Zinc in their crops
Overview Gut and vitamin D contains the following summary
- Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
- Celiac disease has a strong genetic component.
- Most, but not all, people with celiac disease have a gene variant.
- An adequate level vitamin D seems to decrease the probability of getting celiac disease.
- Celiac disease causes poor absorption of nutrients such as vitamin D.
- Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
- The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
- Review in Nov 2013 found that Vitamin D helped
Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
- All items in category gut and vitamin D
Gut category listing contains the following
158 items in GUT category - see also Overview Gut and vitamin D,
- "Ulcerative Colitis" OR UC 839 items Jan 2020
- "celiac disease" OR CD 1830 items July 2019
- "inflammatory bowel disease" OR "inflammatory bowel symptom" 1630 items as of Jan 2020
- Crohn's 1230 items as of Feb 2019
- Gut-Friendly forms of vitamin D
such as: bio-emulsion, topical, spray, sublingual, inhaled, injection . .
< 40 years, 3.7 X more likely to have low Zinc
" patients younger than 40 years were at increased risk for zinc deficiency (RR, 3.683; 95% CI, 1.152 to 11.777; p=0.028) "
Females 4.9 X more likely to have low Selenium
"Female sex (RR, 4.871; 95% CI, 1.352 to 17.544; p=0.015) and low serum albumin levels (<3.3 g/dL; RR, 10.346; 95% CI, 1.035 to 103.447; p=0.047) were independent risk factors for selenium deficiency by multivariate logistic regression analysis"
Studies on the micronutrient status of Asian patients with inflammatory bowel disease (IBD) are scarce. We evaluated the prevalence of micronutrient deficiency and verified the risk factors for micronutrient deficiency in Korean patients with IBD.
We measured the serum levels of 25-hydroxyvitamin D3 [25-(OH)D], zinc, and selenium to analyze the clinical risk factors for micronutrient levels below the reference values. In addition, we compared the 25-(OH)D levels of patients with IBD to those of age- and sex-matched healthy controls.
Among the 83 patients, 74 (89.2%) had suboptimal serum 25-(OH)D levels. The mean plasma 25-(OH)D level in patients with IBD was significantly reduced compared to that of the healthy controls (12.3±6.2 ng/mL vs 20.0±6.7 ng/mL; p<0.001).
The proportions of patients with lower serum zinc and selenium levels were 39.0% and 30.9%, respectively. Female sex (p=0.012) and Crohn's disease (p=0.012) were associated with vitamin D deficiency.
Patients younger than 40 years were at increased risk for zinc deficiency (p=0.045).
Female sex (p=0.015) and low serum albumin level (<3.3 g/dL) (p=0.047) were risk factors for selenium deficiency.
Many Korean patients with IBD have vitamin D, zinc, and selenium deficiencies, suggesting the necessity for monitoring levels of these micronutrients.
PMID: 28208007 PMCID: PMC5417778 DOI: 10.5009/gnl16333
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