Vitamin D associates with improved quality of life in participants with irritable bowel syndrome: outcomes from a pilot trial
BMJ Open Gastro 2015; 2:e000052 doi:10.1136/bmjgast-2015-000052
Simon Tazzyman1, Nicholas Richards1, Andrew R Trueman1, Amy L Evans1, Vicky A Grant1, Iveta Garaiova2, Sue F Plummer2, Elizabeth A Williams3, Bernard M Corfe1
1Academic Unit of Surgical Oncology, Department of Oncology, University of Sheffield, Sheffield, UK
2Research Department, Cultech Ltd, Baglan Industrial Park, Port Talbot, UK
3Human Nutrition Unit, Department of Oncology, University of Sheffield, Sheffield, UK
- The followup happened in summer - wheh everyone, including palcebo group, also got vitamin D from the sun
- They probably would have needed more vitamin D (5,000 IU?) if the test had been rin a different season
- Spray was used to virtually eliminate absorption problems in the irritated gut
- Note: there are gut-friendly forms of vitamin D which can also be used
See also VitaminDWiki
- IBS (1 in 5 youths) strongly associated with low vitamin D – Dec 2018
- Vitamin D sprayed inside cheeks 2X more response (poor gut) – RCT Oct 2015
- perhaps sprayed vitamin D is more bio-available than oral vitamin D for those with poor guts
- Topical vitamin D raised blood level to 38 ng (better compliance than oral) – RCT March 2014 topical works too!
- Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015 yet another form of Vitamin D
- Getting Vitamin D into your body has a summary chart
- Low Cost vitamin D - including liquid and bulk see Biotics Research gut friendly form of vitamin D
- Overview Gut and vitamin D contains the following summary
- Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
- Celiac disease has a strong genetic component.
- Most, but not all, people with celiac disease have a gene variant.
- An adequate level vitamin D seems to decrease the probability of getting celiac disease.
- Celiac disease causes poor absorption of nutrients such as vitamin D.
- Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
- The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
- Review in Nov 2013 found that Vitamin D helped
- Many intervention clinical trials for vitamin D to prevent or treat Gut problems (93 trials listed as of Jan 2017)
- All items in category gut and vitamin D
- Alternatives if not swallow pills or not absorb vitamin D - topical, sublingual, etc.
- Getting Vitamin D into your body has the following chart
- Irritable Bowel Syndrome treated by weekly 50,000 IU Vitamin D – RCT 2019
- Ulcerative Colitis inflammation treated by weekly vitamin D (40,000 IU) – July 2018
- Gut bacteria of Crohn's disease patients improved by Vitamin D – March 2018
- Crohn's Disease relapse rate of 3 in 8 with 1,000 IU vs 0 in 12 with 10,000 IU of Vitamin D – RCT Feb 2017
- Ulcerative colitis treated by injection of 300,000 IU of vitamin D – RCT July 2016
- IBS quality of life improved by vitamin D (50,000 IU every two weeks) – RCT May 2016
- IBS – 82 percent had low vitamin D, 3,000 IU spray helped a lot – RCT Dec 2015
- Crohn's disease treated by 2000 IU Vitamin D - RCT June 2015
- Crohn’s disease helped when vitamin D level raised above 30 ng – RCT Feb 2015
- Irritable Bowel Syndrome - can it be treated by 3000 IU of vitamin D - RCT Feb 2014
- Crohn's Disease patients normalizing their Vitamin D levels decreased risk of surgery by 44 percent – Aug 2013
- Crohn’s helped by 5000 IU vitamin D – April 2013
Vitamin D deficiency has been associated or implicated with the pathophysiology of the gastrointestinal conditions inflammatory bowel disease and colorectal cancer, as well as with depression. No trials or epidemiology studies to date have investigated a link with irritable bowel syndrome (IBS). A single case report has suggested a benefit in IBS of vitamin D supplementation. We hypothesised that IBS participants with vitamin D insufficiency would benefit from repletion in terms of their IBS symptoms. We undertook a pilot trial to provide data to support a power calculation and to justify a full trial.
This was a randomised, double blinded, three-arm parallel design trial of vitamin D, placebo or a combination of vitamin D and probiotics. Participants were further stratified according to whether they were vitamin D replete or insufficient. Vitamin D status was determined by blood test at baseline and exit; IBS symptoms were assessed by validated questionnaire; dietary intakes were assessed by food frequency questionnaire.
A significant proportion of the IBS population were vitamin D deficient, such that the replete stratum could not be adequately recruited. There was a significant association in the baseline data between circulating vitamin D level and quality of life (“How much has IBS affected your life?”). Supplementation significantly improved vitamin D level versus placebo. IBS symptoms were not significantly improved in this pilot, although a power calculation was enabled from the intervention data.
The IBS population exhibits significant levels of vitamin D insufficiency and would benefit from screening and possible supplementation. The impact of IBS on quality of life may be reduced by vitamin D level. Future trials should have a sample size of over 97.
Trial registration number: ICTRN 6116003917.
- “Study participants were recruited in the early months of 2014 ( January–April) with most follow-up visits taking place from May to August, most likely explaining the rise in 25OHD in all groups.”
- Large proportion of IBS sufferers are vitamin D deficient ScienceDaily Dec 2015
"Researcher Vicky Grant has suffered with IBS for over 30 years. She reported a significant improvement in her symptoms following an introduction to a high-dose of vitamin D3 supplement approximately five years ago."
"IBS is a chronic and debilitating functional disorder of the gastrointestinal (GI) tract which affects around 10-15 per cent of the western population."