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IBS – 82 percent had low vitamin D, 3,000 IU spray helped a lot – RCT Dec 2015

Vitamin D associates with improved quality of life in participants with irritable bowel syndrome: outcomes from a pilot trial

BMJ Open Gastro 2015; 2:e000052 doi:10.1136/bmjgast-2015-000052
Simon Tazzyman1, Nicholas Richards1, Andrew R Trueman1, Amy L Evans1, Vicky A Grant1, Iveta Garaiova2, Sue F Plummer2, Elizabeth A Williams3, Bernard M Corfe1
1Academic Unit of Surgical Oncology, Department of Oncology, University of Sheffield, Sheffield, UK
2Research Department, Cultech Ltd, Baglan Industrial Park, Port Talbot, UK
3Human Nutrition Unit, Department of Oncology, University of Sheffield, Sheffield, UK

VitaminDWiki
  • The followup happened in summer - wheh everyone, including palcebo group, also got vitamin D from the sun
  • They probably would have needed more vitamin D (5,000 IU?) if the test had been rin a different season
  • Spray was used to virtually eliminate absorption problems in the irritated gut
  • Note: there are gut-friendly forms of vitamin D which can also be used

See also VitaminDWiki

  • Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
  • Celiac disease has a strong genetic component.
    • Most, but not all, people with celiac disease have a gene variant.
    • An adequate level vitamin D seems to decrease the probability of getting celiac disease.
    • Celiac disease causes poor absorption of nutrients such as vitamin D.
    • Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
    • The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
  • Review in Nov 2013 found that Vitamin D helped
    Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
  • All items in category gut and vitamin D 150 items

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Intervention AND Gut

Vitamin D levels for those who initially had < 20 ng

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Background
Vitamin D deficiency has been associated or implicated with the pathophysiology of the gastrointestinal conditions inflammatory bowel disease and colorectal cancer, as well as with depression. No trials or epidemiology studies to date have investigated a link with irritable bowel syndrome (IBS). A single case report has suggested a benefit in IBS of vitamin D supplementation. We hypothesised that IBS participants with vitamin D insufficiency would benefit from repletion in terms of their IBS symptoms. We undertook a pilot trial to provide data to support a power calculation and to justify a full trial.

Methods
This was a randomised, double blinded, three-arm parallel design trial of vitamin D, placebo or a combination of vitamin D and probiotics. Participants were further stratified according to whether they were vitamin D replete or insufficient. Vitamin D status was determined by blood test at baseline and exit; IBS symptoms were assessed by validated questionnaire; dietary intakes were assessed by food frequency questionnaire.

Results
A significant proportion of the IBS population were vitamin D deficient, such that the replete stratum could not be adequately recruited. There was a significant association in the baseline data between circulating vitamin D level and quality of life (“How much has IBS affected your life?”). Supplementation significantly improved vitamin D level versus placebo. IBS symptoms were not significantly improved in this pilot, although a power calculation was enabled from the intervention data.

Conclusions
The IBS population exhibits significant levels of vitamin D insufficiency and would benefit from screening and possible supplementation. The impact of IBS on quality of life may be reduced by vitamin D level. Future trials should have a sample size of over 97.

Trial registration number: ICTRN 6116003917.

  • “Study participants were recruited in the early months of 2014 ( January–April) with most follow-up visits taking place from May to August, most likely explaining the rise in 25OHD in all groups.”

 Download the PDF from VitaminDWiki

This study was reported on the web in many places - such as

  • Large proportion of IBS sufferers are vitamin D deficient ScienceDaily Dec 2015
    "Researcher Vicky Grant has suffered with IBS for over 30 years. She reported a significant improvement in her symptoms following an introduction to a high-dose of vitamin D3 supplement approximately five years ago."
    "IBS is a chronic and debilitating functional disorder of the gastrointestinal (GI) tract which affects around 10-15 per cent of the western population."

Attached files

ID Name Comment Uploaded Size Downloads
6267 IBS deficient.jpg admin 21 Dec, 2015 21:20 17.64 Kb 1145
6264 IBS Dec 2015.pdf PDF 2015 admin 21 Dec, 2015 21:02 997.63 Kb 435
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