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Vitamin D – water-soluble is far more absorbable than fat-soluble – Nov 2016

Efficacy of micellized vs. fat-soluble vitamin D3 supplementation in healthy school children from Northern India.

J Pediatr Endocrinol Metab. 2016 Nov 16. pii: /j/jpem.ahead-of-print/jpem-2016-0191/jpem-2016-0191.xml. doi: 10.1515/jpem-2016-0191. [Epub ahead of print]
Marwaha RK, Yenamandra VK, Ganie MA, Sethuraman G, Sreenivas V, Ramakrishnan L, Mathur SK, Sharma VK, Mithal A.

VitaminDWiki Summary
60,000 IU Vitamin D
monthly for 6 months
Water-soluble in water 32 ng100%
Fat-soluble in 4% milk24 ng83%

  • 28 liquid Vitamin D products have Micellization technology on Amazon as of Nov 2016
    Up to 2,000 IU per drop
  • Bio-Tech is the only company I am aware of that makes a non-liquid water-soluble form of vitamin D
  • Vitamin D3 forms- powder best – April 2014
    Which shows that the powder (which is water-soluble) form of Vitamin D is the most bio-available

The PDF ($42) indicates

Vitamin D deficiency is a widely recognized public health problem. Efficacy of a recently developed micellized form of vitamin D3 has not been studied. Hence, we undertook this study to compare its efficacy with the conventionally used fat-soluble vitamin D3.

In this open-labeled nonrandomized pilot study, we recruited 180 healthy children, aged 13-14 years in two groups and supplemented Group A (60 children) with 60,000 IU of fat-soluble vitamin D3/month with milk and Group B (120 children) with 60,000 IU/month of water miscible vitamin D3 under supervision for 6 months. Serum 25(OD)D, parathyroid hormone (PTH), calcium, phosphate, and alkaline phosphatase (ALP) levels were evaluated before and after supplementation in 156 children (54 in Group A and 102 in Group B ) who completed the study.

We observed a significantly greater increase in the serum 25(OH)D levels in group B as compared to group A (31.8±9.1 ng/mL vs. 23.7±10.4 ng/mL; p<0.001). All children in group B achieved adequate levels of serum 25(OH)D (>20 ng/mL) as against 83.3% children in group A. Serum PTH and ALP levels declined considerably in both the groups following supplementation.

Vitamin D supplementation significantly increased the serum 25(OH)D levels in both groups. Miscible form of vitamin D3 appears to be better in achieving higher levels of serum 25(OH)D than that observed with a similar dose of fat-soluble vitamin D3. Further studies with different dose regimens are required to establish its efficacy over the conventionally used fat-soluble vitamin D3.

PMID: 27849624 DOI: 10.1515/jpem-2016-0191
Publisher wants $42 for the PDF

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