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Nanoemulsion Vitamin D is faster and better - many studies

Bought and tested several nanoemulsions
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Note: The following studies compare oral nano vs oil-based vitamin D
I do not recall a study of topical, sublingual or buccal Vitamin D
   that skips the stomach, intestine, liver, and kidneys


Nanoemulsion vitamin D 40% more bio-available than fat-soluble - RCT Jan 2023

An open-label, randomized, crossover study to evaluate the bioavailability of nanoemulsion versus conventional fat-soluble formulation of cholecalciferol in healthy participants
Journal of Orthopaedics Volume 35, January 2023, Pages 64-68 https://doi.org/10.1016/j.jor.2022.10.017
Raman Kumar Marwaha a, Manish Verma b 1, Ajit Walekar c, Rakesh Sonawane b 2, Chirag Trivedi c

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Background
Nanoemulsion preparations of cholecalciferol available in the market claim to have better bioavailability than the conventional fat-soluble cholecalciferol. However, limited data are available in humans for such preparations. We, therefore, compared the relative bioavailability of two formulations of 60,000 IU cholecalciferol (nanoemulsion oral solution, water-miscible vitamin D3 [test] vs soft gelatin capsules [reference]) in healthy adult participants.

Methods
In this randomized, open-label, two-sequence, single-dose, two-way crossover study (CTRI/2018/05/013839), Indian participants aged 18–45 years received single dose of nanoemulsion and capsule formulations, under fasting conditions. Blood samples collected over 120 h were assessed to determine cholecalciferol concentrations. Pharmacokinetic parameters (area under the concentration-time curve up to 120 h [AUC0–120h], maximum observed drug concentration [Cmax], time to reach maximum drug concentration [Tmax], terminal half-life [T½el], and terminal elimination rate constant Kel) were estimated using baseline corrected data and analyzed using analysis of variance.

Results
Among the 24 eligible participants, the relative bioavailability of nanoemulsion was significantly higher than the capsules by 36% (p = 0.0001) based on AUC0–120h. Similarly, Cmax of the nanoemulsion was significantly higher by 43% (p = 0.0001) than that of the capsules. The intra-participant variability for AUC0–120h and Cmax were 23.22% and 26.51%, respectively. The Tmax, T½el, and Kel were comparable for both the formulations. No adverse effects were noted with either of the two formulations.

Conclusions
Nanoemulsion oral solution of cholecalciferol showed a greater bioavailability compared with soft gelatin capsules, under fasting conditions, in healthy human participants.
 Download the PDF from VitaminDWiki


Nanoemuslion 36% more bioavailable than fat soluble forms (single 60,000 IU dose) - Dec 2019

Bioavailability of nanoemulsion formulations vs conventional fat soluble preparations of cholecalciferol (D3) – An overview
J. of Clinical Orthopaedics & Trauma Nov–Dec 2019, pg 1094-1096 https://doi.org/10.1016/j.jcot.2019.07.014
Raman Kumar Marwaha a, Aashima Dabas b

Vitamin D deficiency is recognized as a pandemic affecting all ages and strata of population. The endogenous cutaneous synthesis of vitamin D is insufficient to maintain normal body requirement which necessitates the need for vitamin D supplementation or food-fortification. Conventional fat-soluble preparations of vitamin D have been traditionally used for prevention and therapeutic purposes. Recent advances in technology have enabled delivery of vitamin D through nanoemulsion formulations which ensure higher absorption and drug delivery. The following review briefly discusses the issues of bioavailability of nanoemulsion preparation of vitamin D vis-a-vis conventional fat soluble preparations.
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Clipped from PDF
"...a single oral dose of 60,000 IU in healthy participants. The results showed that relative bioavailability in terms of serum levels of cholecalciferol following supplementation with nano preparation of vitamin D3 was significantly higher than fat-soluble D3 by 36%(P ¼ 0.001) based on AUC 0-120. "
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The nanoemulsions are considered superior to conventional vitamin D preparations for the following reasons:

  • a) It has greater therapeutic role in patients with malabsorption syndromes due to
    • Inflammatory bowel disease,
    • Celiac disease,
    • Short bowel syndrome,
    • Hepatobiliary disorders,
    • Pancreatic insufficiency and
    • Bariatric surgery who suffer from a deficiency of essential fatty acids and fat-soluble vitamins including vitamin D,
  • b) Better compliance as it can be taken directly or with water/juice etc.
  • c) Vitamin D nanoemulsions may also have also greater hepato-protective effect against high-fat diet-induced liver injury as observed in rats compared to conventional oral vitamin D preparations.

Current Update on Nanoemulsion A Review - Jan 2021


CoVID19 VitD and Nanotechnology Review EJBPS ; Jan 2020 BioTech


Nanoemulsions for health, food, and cosmetics


Advances in edible nanoemulsions - Digestion, bioavailability, and potential toxicity


Nanoemulsions SciHub 2020


Nanoemulsions - The rising star of antiviral therapeutics


Nanoemulsions: An emerging platform for increasing the efficacy of nutraceuticals in foods


19+ VitaminDWiki pages with NANOEMULSION or EMULSION etc. in the title

This list is automatically updated

Items found: 20
Title Modified
Vitamin D: liposomal and nanoemulsion forms - Chat-GPT Dec 2023 30 Dec, 2023
Nanoemulsion Vitamin D is faster and better - many studies 06 Oct, 2023
Fast responses to Vitamin D – loading dose, nanoemulsion and Calcifediol – April 2023 15 Apr, 2023
Nanoemulsion Vitamin D faster and better (paywall) – RCT Dec 2021 02 Dec, 2021
COVID-19 defeated 3x faster by 420,000 IU Vitamin D nanoemulsion – RCT Nov 12, 2020 21 Sep, 2021
Nanoemulsion Vitamin D may be a substantially better form 02 Jun, 2021
COVID-19 inflammation extinguished by 60,000 IU of vitamin D nanoemulsion daily for a week – RCT May 2021 22 May, 2021
Inhaling Vitamin D nanoemulsion through nose gets lots more to the brain (mice) – July 2020 03 Aug, 2020
Vitamin D nanoemulsion, with comments on COVID-19 – June 2, 2020 04 Jun, 2020
Nanoemulsion vitamin D is again found to be the best liquid form (for rats in this case) – June 2019 20 Dec, 2019
Bioavailability of nanoemulsion formulations of Vitamin D3 – Nov 2019 20 Dec, 2019
Vitamin D nanoemulsion etc. for fortification, pills, injections, topical and cancer – July 2019 18 Jul, 2019
Vitamin D Emulsion update - March 2019 28 Mar, 2019
Vitamin D Emulsions - nano 2X better than coarse – Dec 2017 04 Mar, 2019
Vitamin D nanoemulsion corrected deficiency and improved bones in 1 week (high dose in rats) – Jan 2019 05 Jan, 2019
Advances in Vitamin D emulsions, nanoparticles, etc. – Jan 2019 30 Dec, 2018
Colitis treated by activated vitamin D getting into the colon via emulsion (mice) – July 2018 24 Jul, 2018
Lung cancer and inhaled emulsions (wonder about inhaled Vitamin D) – 2018 17 Jun, 2018
Inhaled nanoemulsion of Vitamin D killed lung bacteria – Sept 2017 19 Apr, 2018
Nanoemulsions of vitamin D help reduce asthma markers in mice– Dec 2013 12 Dec, 2013

See also in VitaminDWiki

50,000 IU powder in capsule
Example Biotech Pharmacal
Nanoemulsion
Example micro D3
Average Cost
per day for 10,000 IU
4 cents8 cents
IU per serving 50,000 IU = capsule2,000 IU = drop
Servings if want average
of 10,000 IU/day
1 capsule
per 5 days
25 drops = 1 /4 teaspoon
per 5 days
Shelf life 1 year?6 months?
Add to food/drinkYes (powder) possiblly
Apply to skinNoYes
Swish in mouth
for fast response
Yes if put powder in saliva
or swish vitamin D water
Yes
Gut-friendlyperhapsprobably
Availability to cell
- better than bio-availability
standardperhaps 2X more
- due to small size
or activation of Vitamin D Receptor

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Attached files

ID Name Comment Uploaded Size Downloads
21025 6 vitamin D bottles highlighted.jpg admin 26 Mar, 2024 52.69 Kb 15
20396 nano bio.png admin 23 Nov, 2023 89.38 Kb 77
20395 Nano bioavailable_CompressPdf.pdf admin 23 Nov, 2023 275.41 Kb 29
15633 Nano emerging platform sci-hub.pdf admin 23 May, 2021 1.71 Mb 287
15632 Nanoemulsions - The rising star of antiviral therapeutics.pdf admin 23 May, 2021 1.74 Mb 388
15631 Nanoemulsions SciHub 2020.pdf admin 23 May, 2021 1.71 Mb 304
15630 Advances in edible nanoemulsions - Digestion, bioavailability, and potential toxicity Jan 2021.pdf admin 23 May, 2021 2.76 Mb 709
15629 Nanoemulsions for health, food, and cosmetics.pdf admin 23 May, 2021 992.54 Kb 315
15628 CoVID19VitDandNanotechnologyReviewEJBPS.pdf admin 23 May, 2021 513.59 Kb 346
15627 Current Update on Nanoemulsion A Review.pdf admin 23 May, 2021 408.31 Kb 455