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Inflammatory Bowel Disease 1.5 X more likely if low vitamin D – meta-analysis Dec 2019

Systematic review with meta-analysis: association of vitamin D status with clinical outcomes in adult patients with inflammatory bowel disease.

Aliment Pharmacol Ther. 2019 Dec;50(11-12):1146-1158. doi: 10.1111/apt.15506. Epub 2019 Oct 24.
Gubatan J1,2, Chou ND1, Nielsen OH3, Moss AC1.


The Meta-analysis of Gut and Vitamin D

All items in categories Intervention AND Gut

Overview Gut and vitamin D has the following summary

  • Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
  • Celiac disease has a strong genetic component.
    • Most, but not all, people with celiac disease have a gene variant.
    • An adequate level vitamin D seems to decrease the probability of getting celiac disease.
    • Celiac disease causes poor absorption of nutrients such as vitamin D.
    • Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
    • The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
  • Review in Nov 2013 found that Vitamin D helped
    Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
  • All items in category gut and vitamin D 204 items

Gut category listing contains the following

204 items in GUT category - see also Overview Gut and vitamin D, See also Microbiome category listing has 37 items along with related searches.

 Download the PDF from VitaminDWiki

Vitamin D deficiency is highly prevalent among patients with IBD, however, data on its association with clinical outcomes are conflicting.

To perform a systematic review and meta-analysis to explore the association of low vitamin D status with clinical outcomes in patients with IBD.

We searched PubMed, Embase, Scopus and Web of Science from inception to February 2018 for observational studies evaluating the association of low 25(OH)D status on IBD disease activity, mucosal inflammation, clinical relapse and quality of life. Odds ratios (ORs) were pooled and analysed using a random effects model.

Twenty-seven studies were eligible for inclusion comprising 8316 IBD patients (3115 ulcerative colitis, 5201 Crohn's disease). Among IBD patients, low 25(OH)D status was associated with increased odds of

  • disease activity (OR 1.53, 95% CI 1.32-1.77, I2 = 0%),
  • mucosal inflammation (OR 1.25, 95% CI 1.06-1.47, I2 = 0%),
  • low quality of life (QOL) scores (OR 1.30, 95% CI 1.06-1.60, I2 = 0%) and
  • future clinical relapse (OR 1.23, 95% CI 1.03-1.47, I2 = 0%).

In subgroup analysis, low vitamin D status was associated with

  • Crohn's disease activity (OR 1.66, 95% CI 1.36-2.03, I2 = 0%),
  • mucosal inflammation (OR 1.39, 95% CI 1.03-1.85, I2 = 0%),
  • clinical relapse (OR 1.35, 95% CI 1.14-1.59, I2 = 0%), and
  • low QOL scores (OR 1.25, 95% CI 1.04-1.50, I2 = 0%) and
  • ulcerative colitis disease activity (OR 1.47, 95% CI 1.03-2.09, I2 = 0%) and
  • clinical relapse (OR 1.20, 95% 1.01-1.43, I2 = 0%).

CONCLUSIONS: Low 25(OH)D status is a biomarker for disease activity and predictor of poor clinical outcomes in IBD patients.

Attached files

ID Name Comment Uploaded Size Downloads
13052 IBD meta.jpg admin 26 Nov, 2019 125.99 Kb 678
13051 IBD Meta-analysis.pdf admin 26 Nov, 2019 854.70 Kb 568