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IBD (Colitis, Crohn’s) was active 6X more often if low vitamin D – June 2015


Vitamin D Deficiency Associated with Disease Activity in Patients with Inflammatory Bowel Diseases.

Dig Dis Sci. 2015 Jun 2. https://doi.org/10.1007/s10620-015-3727-4
Torki M1, Gholamrezaei A, Mirbagher L, Danesh M, Kheiri S, Emami MH
1Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran, rzenderoud at yahoo.com.

BACKGROUND:
Evidence exists on the association between vitamin D deficiency and inflammatory bowel diseases (IBD).

AIMS:
To investigate whether vitamin D level is associated with disease activity and quality of life in IBD patients.

METHODS:
This cross-sectional study was conducted on known adult IBD patients referred to an outpatient clinic of gastroenterology in Isfahan city, Iran. Disease activity was evaluated using the Simplified Crohn's Disease Activity Index and Simple Clinical Colitis Activity Index. Quality of life was assessed with the Short-Inflammatory Bowel Disease Questionnaire. Serum 25[OH]D was measured using the radioimmunoassay method. Vitamin D deficiency and insufficiency were defined as concentration of <50 and 50-75 nmol/L, respectively.

RESULTS:
Studied subjects were 85 ulcerative colitis and 48 Crohn's disease patients (54.1 % females) with mean age of 42.0 ± 14.0 years. Vitamin D deficiency and insufficiency were present in 52 (39.0 %) and 24 (18.0 %) patients, respectively. Thirty patients (22.5 %) had active disease who, compared with patients in remission, had more frequent low vitamin D levels (80 vs. 50.4 %, P = 0.005). Quality of life was not different between patients with low and those with normal vitamin D levels (P = 0.693). In the logistic regression model, low vitamin D was independently associated with active disease status, OR (95 % CI) = 5.959 (1.695-20.952).

CONCLUSIONS:
We found an association between vitamin D deficiency/insufficiency and disease activity in IBD patients. Prospective cohorts and clinical trials are required to clarify the role of vitamin D deficiency and its treatment in clinical course of IBD.
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VitaminDWiki pages with IBD or IBS in title (25 as of May 2022)

This list is automatically updated

Items found: 43
Title Modified
IBS - Vitamin D was the only micronutrient under DRV - meta-analysis Oct 2023 16 Dec, 2023
Vitamin D interactions with poor gut (Celiac, IBD, and Bariatric surgery) – several studies 22 Nov, 2023
IBD associated with low vitamin D again (they need to take a gut-friendly form of Vitamin D) – Oct 2023 14 Oct, 2023
IBS reduced by 50,000 IU of Vitamin D (weekly or bi-weekly) – Meta-analysis July 2023 16 Aug, 2023
IBD treated in children by Vitamin D, especially if use more than 2,000 IU daily for 12 weeks – meta-analysis – Sept 2022 14 Sep, 2022
Vitamin D fights IBD, no consensus yet on dose size and type – Aug 2022 26 Aug, 2022
IBS helped by vitamin D (virtually ignoring dose size, type and duration) – meta-analysis June 2022 09 Jul, 2022
IBD is treated by Vitamin D and other Nutraceuticals – June 2022 23 Jun, 2022
IBD (Colitis, Crohn’s) was active 6X more often if low vitamin D – June 2015 30 May, 2022
IBD in children might be associated with low sun exposure 28 Feb, 2022
IBD strongly associated with low Vitamin D – Jan 2022 09 Jan, 2022
IBS not helped by daily 3,000 IU Vitamin D (but non-daily and gut-friendly help) – RCT July 2021 31 Jul, 2021
IBD and Crohn's patients need Vitamin D, even to increase drug efficacy (Vedolizumab) June 2021 29 Jun, 2021
IBS diarrhea treated by weekly 50,000 IU of Vitamin D – RCT March 2020 25 Mar, 2020
IBD and UV dissertation - 2019 10 Sep, 2019
Vitamin D appears to fight Diabetes, MS, RA, Lupus, IBD, Hepatitis, Cancer, Psoriasis, Food allergy, etc – June 2019 17 Jul, 2019
IBD in Finland – 3X increase in 15 years, more prevalent further from equator – Nov 2012 14 May, 2019
Common cold incidence reduced by two thirds (500 IU for IBD with low vitamin D) – RCT Jan 2019 04 Jan, 2019
Risks of Colorectal Cancer, IBD, etc slightly increased if poor Vitamin D Receptor – Aug 2018 09 Dec, 2018
IBS (1 in 5 youths) strongly associated with low vitamin D – Dec 2018 01 Dec, 2018
IBD relapse rate reduced by low Vitamin D - meta-analysis Nov 2018 27 Nov, 2018
IBS quality of life improved by vitamin D (50,000 IU every two weeks) – RCT May 2016 14 Mar, 2018
IBS - many indications that Vitamin D will help - more research needed - March 2018 14 Mar, 2018
IBS – 6 out of 7 studies shows Vitamin D helps, still want more studies – Jan 2018 25 Jan, 2018
Higher Vitamin D increased the benefit of anti-TNF- α drug used for IBD by 2.6 times – Jan 2017 31 Jan, 2017
IBD in Canadian children increasing 7% per year - Nov 2016 22 Nov, 2016
70 percent of people with IBS had symptoms relieved with high dose vitamin D – 2012 04 Nov, 2016
IBD UC and CD at risk of being vitamin D deficient – May 2011 04 Nov, 2016
IBS – 82 percent had low vitamin D, 3,000 IU spray helped a lot – RCT Dec 2015 25 Aug, 2016
Sleep, Vitamin D, Vitamin B-12, IBS, Fibromyalgia - Gominak March 2015 27 Jul, 2016
IBD deficiencies of Iron and Vitamin D (and new Iron types) – June 2016 20 Jun, 2016
IBS quality of life improved by vitamin D (50,000 IU weekly) – RCT May 2016 17 May, 2016
IBD helped by vitamin D but reluctant to state who helped, in what form, and how much – review Nov 2014 08 Jan, 2016
IBD more likely in areas with low UV ( and thus low vitamin D) – June 2014 05 Dec, 2015
Gut problems more likely if low vitamin D (IBD: 1.6, UC: 2.3) – meta-analysis Aug 2015 31 Oct, 2015
IBD (Collitis, Chron’s) was active 6X more often if low vitamin D – June 2015 03 Oct, 2015
Crohn’s disease deficient in vitamin K – IBD deficient in vitamins K and D – April 2011 17 Feb, 2015
Appears that IBD lowers vitamin D, which increases risk of cancer by 80 percent – Oct 2013 09 Jul, 2014
IBD surgery 5X more likely for non-caucasians with low vitamin D – Oct 2012 03 Nov, 2012
IBD and Crohn but not Colitis associated with low vitamin D – May 2011 05 Jun, 2012
IBD colorectal Cancer and vitamin D – Jan 2011 14 Mar, 2012
Dogs – like humans – with IBD were low on vitamin D – July 2011 14 Mar, 2012
IBD less costly when treated with vitamin D3 compared to D2 – Jan 2012 12 Jan, 2012

VitaminDWiki - Overview Gut and vitamin D contains

  • Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
  • Celiac disease has a strong genetic component.
    • Most, but not all, people with celiac disease have a gene variant.
    • An adequate level vitamin D seems to decrease the probability of getting celiac disease.
    • Celiac disease causes poor absorption of nutrients such as vitamin D.
    • Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
    • The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
  • Review in Nov 2013 found that Vitamin D helped
    Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
  • All items in category gut and vitamin D 204 items

Along with gut-friendly information


VitaminDWiki - Gut category contains

204 items in GUT category - see also Overview Gut and vitamin D, See also Microbiome category listing has 37 items along with related searches.

VitaminDWiki pages with Colitis in (15 as of May 2022)

This list is automatically updated

Items found: 18
Title Modified
Ulcerative Colitis associated with a 90% reduced activation of Vitamin D Receptor – May 2024 16 May, 2024
Ulcerative Colitis and Vitamin D - many studies 18 Oct, 2023
Ulcerative Colitis treated 4X better when Vitamin D was added – Meta-Analysis – July 2022 01 Aug, 2022
IBD (Colitis, Crohn’s) was active 6X more often if low vitamin D – June 2015 30 May, 2022
Ulcerative Colitis significantly reduced by 480,000 IU loading dose of nano Vitamin D – RCT July 2019 21 Sep, 2019
Ulcerative Colitis (new) associated with lower free and bioavailable Vitamin D, but not total – Feb 2019 10 May, 2019
Ulcerative Colitis – half have poor level of Vitamin D Receptor vs only one in ten normally – June 2017 01 Apr, 2019
Ulcerative Colitis much worse if low vitamin D – March 2019 23 Mar, 2019
Turmeric stopped Ulcerative Colitis – RCT Feb 2019 03 Mar, 2019
Ulcerative Colitis inflammation treated by weekly vitamin D (40,000 IU) – July 2018 21 Dec, 2018
Colitis treated by activated vitamin D getting into the colon via emulsion (mice) – July 2018 24 Jul, 2018
Ulcerative colitis treated by injection of 300,000 IU of vitamin D – RCT July 2016 29 Apr, 2017
Ulcerative Colitis relapse 25 percent more likely if vitamin D level is lower than 35 ng – June 2016 18 Jan, 2017
Those with Ulcerative colitis and low vitamin D were 3.3X more likely to have anemia – Oct 2013 18 Jan, 2017
Ulcerative colitis associated with both low Vitamin D and poor Vitamin D Receptors – Oct 2016 24 Nov, 2016
IBD and Crohn but not Colitis associated with low vitamin D – May 2011 05 Jun, 2012
Vitamin D as a therapy for colitis: A systematic review – May 2012 05 Jun, 2012
Colitis associated with low level of vitamin D in mice – April 2010 07 Jul, 2010

Note: My spouse has very successfully used a nanoemulsion vitamin D to treat her colitis

She had severe attacks of ulcerative colitis many times a year for many decades
Adding oral vitamin D did not appear to help
Previously we had great success applying vitamin D directly to a problem
   gums, warts, burns, abrasions, etc.
We evolved ways to get vitamin d directly to this problem
Vitamin D powder added to water helped some when a teaspoon of it was inserted into the rectum
Adding salt to the water helped
100,0000 IU of nanoemulsion also was good
Ended up using 200,000 IU of nanoemulsion vitamin D in 1 pint of water with a "pinch" of - using about a tablespoon at a time
Similar attack frequency, but far less intense.
The problem goes away after 3 nightly applications

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Created by admin. Last Modification: Friday August 5, 2022 16:33:37 GMT-0000 by admin. (Version 11)

Attached files

ID Name Comment Uploaded Size Downloads
17689 IBD sci-hub.pdf admin 29 May, 2022 390.62 Kb 192