Oral supplementation with probiotic L. reuteri NCIMB 30242 increases mean circulating 25-hydroxyvitamin D: a post-hoc analysis of a randomized controlled trial.
J Clin Endocrinol Metab. 2013 Apr 22.
Jones ML, Martoni CJ, Prakash S.
Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering and Physiology, Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, 3775 University St, Montreal, QC, H3A 2B4, Canada.
Context:Low serum 25-hydroxyvitamin D is a risk factor for osteoporosis, cardiovascular disease, diabetes and cancer. Disruption of non-cholesterol sterol absorption due to cholesterol lowering therapies may result in reduced fat soluble vitamin absorption.
Objective:We have previously reported on the cholesterol lowering efficacy and reduced sterol absorption of probiotic bile salt hydrolase active L. reuteri NCIMB 30242; however, the effects on fat soluble vitamins was previously unknown and the objective of the present study.Design, Settings,
Patients and Intervention:The study was double-blind, placebo-controlled, randomized, parallel-arm, multi-center lasting 13 weeks. 127 otherwise healthy hypercholesterolemic adults with LDL-cholesterol >3.4 mmol/l, triglycerides <4.0 mmol/l and body mass index of 22-32 kg/m2 were included. Subjects were recruited from 6 private practices in Prague, CZ and randomized to consume L. reuteri NCIMB 30242 or placebo capsules over a 9-week intervention period.
Outcome measures:The primary outcome measure was the change in serum LDL-cholesterol over the 9-week intervention. Analysis of fat soluble vitamins at Weeks 0 and 9 were performed post-hoc.
Results:There were no significant differences between L. reuteri NCIMB 30242 and placebo capsule groups in serum vitamin A, vitamin E, β-carotene or dietary intake over the intervention period (P>0.05). L. reuteri NCIMB 30242 increased serum 25-hydroxyvitamin D by 14.9 nmol/l or 25.5% over the intervention period, which was a significant mean change relative to placebo of 17.1 nmol/l or 22.4% respectively (P=0.003).
Conclusions:To our knowledge this is the first report of increased circulating 25-hydroxyvitamin D in response to oral probiotic supplementation.
PMID: 23609838; $37 paywall
- Vitamin D is the 2nd most important nutrient - survey Aug 2011 probiotics is 6th
- Are microbs – probiotics – vitamin D – allergy – asthma – obesity related – Mar 2011
- Hypothesis: vitamin D and probiotics will reduce type II diabetes – Jan 2013
- Overview Gut and vitamin D
- intestinal mal-absorption of vitamin D - Holick 1985.pdf file, not web page, does not mention probiotics
- Review of this study Review of this study, behind a $5/month paywall
About 1/3 did not get any increase in vitamin D levels
- Hypercholesterolemia is the presence of high levels of cholesterol in the blood.
- While very interesting, people without high cholesterol may not get any vitamin D benefit from Lactobacillus probiotic
- Likewise, no data on increase of vitamin D from other types of probiotics