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T1 Diabetes associated with many other autoimmune diseases (all related to low vitamin D) – May 2017

Vitamin D levels in newly diagnosed type I diabetes mellitus and relation ship with organ specific autoimmune disorders

Endocrine Abstracts (2017) 49 EP418 | DOI:10.1530/endoabs.49.EP418
19th European Congress of Endocrinology, Lisbon, Portugal
20 May 2017 - 23 May 2017, European Society of Endocrinology
Belgin Efe1, Gonca Akdere2 & Goknur Yorulmaz1
1 ESOGU Faculty of Medicine Department of Endocrinology, Eskisehir, Turkey;
2 ESOGU Faculty of Medicine Department of Internal Medicine, Eskisehir, Turkey.

VitaminDWiki

Diabetes leads to many non-autoimmune diseases too

Diabetes ==> Cognitive impairment
Diabetes ==> Vertebral fracture in men only
Diabetes ==> Rheumatoid Arthritis
Diabetes ==> Pancreatic Cancer
Diabetes ==> Alzheimer's
Depression <==> Diabetes


Overview Diabetes and vitamin D contains the following summary

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 417 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

  • Appears that >2,000 IU will Prevent
  • Appears that >4,000 IU will Treat , but not cure
  • Appears that Calcium and Magnesium are needed for both Prevention and Treatment
        which are just some of the vitamin D cofactors

Pages listed in BOTH of the categories Diabetes and Infant/Child - (a proxy for Type 1)

Autoimmune Diseases have been increasing - Oct 2015

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Based on the effects of Vitamin D on immune system it has been suggested that vitamin D may play a role in the pathogenesis of type I diabetes mellitus (T1D) and other organ specific autoimmune disorders. In our study, we aimed to show the effect of Vitamin D deficiency in the development of newly diagnosed T1D and other autoimmune disease that may associated with T1D such as autoimmune thyroid disease (ATD), celiac disease, Addison’s disease, vitiligo and atrophic gastritis. In addition to 50 newly diagnosed T1D patients and 60 healthy controls, we evaluated the data of the formerly diagnosed 50 T1D patients. The frequency of vitamin D deficiency in newly diagnosed T1D patients was found 88%.

  • 30% of these patients were anti parietal cell antibody (APA) positive which is marker for pernicious anemia,
  • 24% of had ATD,
  • 10% of was positive for anti-tissue transglutaminase IgA which is marker for celiac disease and
  • 2% of had vitiligo.

Levels of 25(OH)D were statistically significant lower in newly diagnosed T1D patients with positive APA than patients with negative APA. Frequency of vitamin D deficiency was 66.7% in healthy controls and 84% in formerly diagnosed T1D patients.
When we considered all T1D patients, we found the

  • frequency of ATD was 25%,
  • frequency of positive APA was 28%,
  • frequency of positive anti-tissue transglutaminase IgA was 10% and
  • frequency of vitiligo was 2%.

We found that ATD and predisposition of celiac disease were much frequent in T1D patients than healthy controls. Vitamin D levels were found lower; in patients with T1D than healthy controls; when we evaluate all subjects we found that patients with ATD had lower vitamin D levels than patients without ATD and also patients with ATD and positive APA had lower vitamin D levels than patients without ATD and negative APA.

Created by admin. Last Modification: Saturday January 20, 2018 11:43:31 GMT-0000 by admin. (Version 7)
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