Vitamin D levels in newly diagnosed type I diabetes mellitus and relation ship with organ specific autoimmune disorders
Endocrine Abstracts (2017) 49 EP418 | DOI:10.1530/endoabs.49.EP418
19th European Congress of Endocrinology, Lisbon, Portugal
20 May 2017 - 23 May 2017, European Society of Endocrinology
Belgin Efe1, Gonca Akdere2 & Goknur Yorulmaz1
1 ESOGU Faculty of Medicine Department of Endocrinology, Eskisehir, Turkey;
2 ESOGU Faculty of Medicine Department of Internal Medicine, Eskisehir, Turkey.
Again - if you have one disease related to low vitamin D you MUST supplement so as minimize getting other diseases also associated with low vitamin D
- Diabetes (Type 1) increasing 4 percent per year, now 30,000 in the UK - May 2015
- Type 1 diabetes helped with 50,000 IU of vitamin D every two weeks – Nov 2014
- Type 1 Diabetes association with poor Vitamin D Receptor: 39 studies – April 2017 The poor Vitamin D receptor makes for low vitamin D in cells - not just those associated with T1 Diabetes
- Interview of Dr. Coimbra - Vitamin D protocol for Autoimmune diseases – 2016
- Autoimmune disease clusters run in families (polyautoimmunity) are associated with low vitamin D
Diabetes leads to many non-autoimmune diseases too
Diabetes ==> Cognitive impairment
Diabetes ==> Vertebral fracture in men only
Diabetes ==> Rheumatoid Arthritis
Diabetes ==> Pancreatic Cancer
Diabetes ==> Alzheimer's
Depression <==> Diabetes
Overview Diabetes and vitamin D contains the following summary
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on - All items in category Diabetes and Vitamin D
396 items: both Type 1 and Type 2 Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- Appears that Calcium and Magnesium are needed for both Prevention and Treatment
which are just some of the vitamin D cofactors
Pages listed in BOTH of the categories Diabetes and Infant/Child - (a proxy for Type 1)
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
- T1 Diabetes – how it may be prevented and treated by Vitamin D – Dec 2018
- Vitamin D and Omega-3 may treat Type 1 Diabetes – RCT 2024
- Type 1 Diabetes is increasing – decreased vitamin D is one of the many possible reasons – Sept 2018
- Early Type 1 Diabetes May Shorten Women’s Lives by 18 Years - Aug 2018
- Type 1 Diabetes (T1DM) 1.6 X more likely if low vitamin D – meta-analysis Jan 2018
- Type 1 Diabetes 14 percent more likely with 2 Vitamin D Receptor mutations – Oct 2017
- T1 Diabetes associated with many other autoimmune diseases (all related to low vitamin D) – May 2017
- Vitamin D deficiency is associated with prediabetes in obese Swedish children – Oct 2016
- Type 1 diabetes 1.6 times more likely if a Vitamin D Receptor problem – Feb 2017
- Type II Diabetes in children in India increased 4 X in 20 years – Nov 2016
- Type 1 diabetes risk not decreased if add 400 IU vitamin D while pregnant (no surprise) – Dec 2016
- Diabetes in child not prevented by a tiny amount of vitamin D during pregnancy – Nov 2015
- Diabetes (Type 1) increasing 4 percent per year, now 30,000 in the UK - May 2015
- T1 diabetes in children helped with two doses of 150,000 IU of vitamin D and Calcium – March 2015
- Type 1 diabetes helped with 50,000 IU of vitamin D every two weeks – Nov 2014
- T1 Diabetes associated with low vitamin D - Nov 2014
- Type I Diabetes stopped increasing in Finland after Vitamin D levels were raised – July 2014
- Diabetic children often need more than 7,000 IU of vitamin D – June 2014
- T1 Diabetes 35 percent more likely if 10 degrees further from equator (less vitamin D) – June 2014
- Higher vitamin D at birth associated with less diabetes and obesity 35 years later – Jan 2014
- Type 1 diabetes 3.5X more frequent if low vitamin D - Medscape CME Dec 2012
- Metabolic Syndrome in children is associated with low vitamin D – review Jan 2013
- Like their diabetic mothers, infants had low vitamin D and were slightly diabetic – May 2012
- Type I diabetes 2X more likely if mother had low vitamin D – Jan 2012
Autoimmune Diseases have been increasing - Oct 2015
Based on the effects of Vitamin D on immune system it has been suggested that vitamin D may play a role in the pathogenesis of type I diabetes mellitus (T1D) and other organ specific autoimmune disorders. In our study, we aimed to show the effect of Vitamin D deficiency in the development of newly diagnosed T1D and other autoimmune disease that may associated with T1D such as autoimmune thyroid disease (ATD), celiac disease, Addison’s disease, vitiligo and atrophic gastritis. In addition to 50 newly diagnosed T1D patients and 60 healthy controls, we evaluated the data of the formerly diagnosed 50 T1D patients. The frequency of vitamin D deficiency in newly diagnosed T1D patients was found 88%.- 30% of these patients were anti parietal cell antibody (APA) positive which is marker for pernicious anemia,
- 24% of had ATD,
- 10% of was positive for anti-tissue transglutaminase IgA which is marker for celiac disease and
- 2% of had vitiligo.
Levels of 25(OH)D were statistically significant lower in newly diagnosed T1D patients with positive APA than patients with negative APA. Frequency of vitamin D deficiency was 66.7% in healthy controls and 84% in formerly diagnosed T1D patients.
When we considered all T1D patients, we found the- frequency of ATD was 25%,
- frequency of positive APA was 28%,
- frequency of positive anti-tissue transglutaminase IgA was 10% and
- frequency of vitiligo was 2%.
We found that ATD and predisposition of celiac disease were much frequent in T1D patients than healthy controls. Vitamin D levels were found lower; in patients with T1D than healthy controls; when we evaluate all subjects we found that patients with ATD had lower vitamin D levels than patients without ATD and also patients with ATD and positive APA had lower vitamin D levels than patients without ATD and negative APA.
T1 Diabetes associated with many other autoimmune diseases (all related to low vitamin D) – May 2017
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