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Respiratory infection in infant was 7 X more likely if low cord Vitamin D – March 2017

Low cord-serum 25-hydroxyvitamin D levels are associated with poor lung function performance and increased respiratory infection in infancy

PLoS One. 2017; 12(3): e0173268. PMCID: PMC5340372
Shen-Hao Lai,1,2,3 Sui-Ling Liao,2,3,4 Ming-Han Tsai,2,3,4 Man-Chin Hua,2,3,4 Chih-Yung Chiu,2,3,4 Kuo-Wei Yeh,1,2,3 Tsung-Chieh Yao,#1,2,3,* and Jing-Long Huang#1,2,3,*


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Perinatal vitamin D deficiency is associated with a higher risk of wheezing in childhood. However, the relationship between vitamin D levels and lung function in infancy has not been investigated. The aim of this study was to investigate the impact of perinatal vitamin D levels on respiratory function and disease outcome in infancy.

Materials and methods
Full-term infants without any chronic diseases or major anomalies were enrolled in the Prediction of Allergies in Taiwanese Children cohort study. Maternal and cord blood were collected for determining the 25(OH)D level. Questionnaires were recorded at birth and 6 months of age. Infant lung function, including tidal breathing analysis, respiratory mechanics, and forced tidal expiration, was tested at 6 months of age.

A total of 122 mother—infant pairs were enrolled in this study, and 71 infants underwent lung function testing at 6 months of age. 25(OH)D levels in maternal and cord serum were highly correlated (r2 = 0.457, p < 0.0001). Infants with lower cord serum 25(OH)D levels (< 13.7 ng/ml) had higher resistance of respiratory system (p < 0.01) and a higher risk of a respiratory tract infection before the age of 6 months (p < 0.01).

Although a high correlation was found between maternal and cord vitamin D levels, the effect on respiratory outcome was different. Our study is the first to show that low cord 25(OH)D levels significantly relationship with poorer lung function performance and higher likelihood of a respiratory tract infection before 6 months of age.

Created by admin. Last Modification: Saturday March 7, 2020 16:03:36 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
8488 Low Cord T4.jpg admin 28 Sep, 2017 43.34 Kb 618
8487 low cord D 7X increased risk of RTI.pdf admin 28 Sep, 2017 1.39 Mb 693