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Viral Pneumonia in children 52 X more-likely if very low vitamin D (trend) – June 2017

Relationship Between Vitamin D Status and Viral Pneumonia in Children

Pediatric Allergy, Immunology, and Pulmonology. June 2017, 30(2): 86-91. https://doi.org/10.1089/ped.2017.0750

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Low vitamin D in children is associated with a wide range of breathing problems

Lin-Ying Guo, MD,1 Wei Li, MD,1 Xian-Fen Cheng, MD,2 Hong-Ri Li, MD,1 Chun-Rong Sun, MD,2 Jing Guo, MD,1 Guo-Wei Song, MD,1 Xiao-Dai Cui, MD,2 and Qi Zhang, MD1 zhangqi0355 at sina.com
1 Intensive Care Unit, Affiliated Children's Hospital of Capital Institute of Pediatrics, Beijing, China.
2 Central Laboratory, Capital Institute of Pediatrics, Beijing, China.

This study investigated the impact of vitamin D status on the susceptibility and severity of viral pneumonia (VP) in children. A total of 236 children with VP, aged from 1 month to 14 years, and 271 gender and age matched healthy children to compare the serum 25(OH)D levels and vitamin D status. Vitamin D indices were compared between subgroups in VP cases. The median [interquartile range (IQR)] serum 25(OH)D level in these 507 children was 23.7 (IQR 17.5–30.6) ng/mL; 134 (26.4%) children were vitamin D sufficient [25(OH)D ≥30 ng/mL], whereas 373 (73.6%) were insufficient, which included insufficient [25(OH)D 20–30 ng/mL], deficient [25(OH)D 10–20 ng/mL], and severely deficient [25(OH)D ≤10 ng/mL]. The median (IQR) serum 25(OH)D level in the VP group was significantly lower than that in the control group [19.6 (12.3–26.4) ng/mL versus 26.6 (21.4–32.9) ng/mL] (P < 0.001).
The proportions of vitamin D deficiency (32.2% versus 19.5%) and severe deficiency (19.1% versus 0.4%) in the VP group were significantly higher than those in the control group (P < 0.001).
As vitamin D status decreased, the odds ratio (95% confidence interval) for VP showed an increasing trend [sufficiency (0.3; 0.2–0.5), insufficiency (0.9; 0.6–1.3), deficiency (2.0; 1.3–2.9), and severe deficiency (51.7; 7.2–372.2)].
The median (IQR) serum 25(OH)D level in the VP subgroup who accepted mechanical ventilation was significantly lower than that in the nonmechanical ventilation subgroup [12.9(6.5–22.5) ng/mL versus 20.8 (14.2–28.0) ng/mL] (P < 0.001).
Poor vitamin D status might be related to the susceptibility and severity of VP in children.

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Created by admin. Last Modification: Sunday June 25, 2017 16:55:59 GMT-0000 by admin. (Version 3)