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Immature lungs in immature newborns – Vitamin D helps – Sept 2018

Updates on the Status of Vitamin D as a Risk Factor for Respiratory Distress Syndrome.

Adv Pharmacol Sci. 2018 Sep 30;2018:8494816. doi: 10.1155/2018/8494816. eCollection 2018.

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Vitamin D treats RDS in animal studies


Gatera VA1, Abdulah R1, Musfiroh I2, Judistiani RTD3, Setiabudiawan B4.
1 Dept of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia.
2 Dept of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia.
3 Dept of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
4 Dept of Child Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.

To update the guidelines regarding vitamin D status in respiratory distress syndrome, we reviewed recent human and animal studies on the benefits of vitamin D in respiratory distress. We searched PubMed and ProQuest for studies on the use of vitamin D from 2009 to 2017. The common parameters in these studies included the use of lung tissue, phospholipids, blood, and plasma to assess the effects of vitamin D on respiratory syndrome. The metabolized form of vitamin D used in these studies was 1,25(OH)2D3 in animal studies and 25(OH)D in human studies. Vitamin D supplementation decreases the risk of respiratory distress syndrome, improves the quality of life, and is relatively effective and safe for preterm neonates as well as during lung maturation. However, although vitamin D supplementation may offer benefits for respiratory distress syndrome, the optimal dosing strategies for specific types of risk factors in the lungs must be clarified to confirm the therapeutic efficacy.

From Conclusion in PDF
The results of our summary suggest the benefits of vitamin D supplementation at doses of 250–1000 IU/kg in animals

Created by admin. Last Modification: Saturday October 27, 2018 13:23:45 GMT-0000 by admin. (Version 6)

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10743 RDS Animal studies.jpg admin 27 Oct, 2018 13:19 172.78 Kb 350
10742 Gatera-2018-Updates-on-the-status-of-vitamin-d-.pdf PDF 2018 admin 27 Oct, 2018 13:13 1.29 Mb 406
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