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Type 1 Diabetes is prevented and treated by Vitamin D – review of 16 studies – Sept 2019

Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes

Nutrients. 2019 Sep 11;11(9). pii: E2185. doi: 10.3390/nu11092185.
Infante M1,2, Ricordi C3, Sanchez J4, Clare-Salzler MJ5, Padilla N6, Fuenmayor V7, Chavez C8, Alvarez A9, Baidal D10, Alejandro R11, Caprio M12,13, Fabbri A14.

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Items in both categories Diabetes and Infant-Child (proxie for T1D):

Items in categories Diabetes and Infant-Child (proxie for T1D) and Vitamin D Receptor:

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Table of Contents
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Type 1 diabetes (T1D) is a chronic autoimmune disease leading to immune-mediated destruction of pancreatic beta cells, resulting in the need for insulin therapy. The incidence of T1D is increasing worldwide, thus prompting researchers to investigate novel immunomodulatory strategies to halt autoimmunity and modify disease progression.

T1D is considered as a multifactorial disease, in which genetic predisposition and environmental factors interact to promote the triggering of autoimmune responses against beta cells. Over the last decades, it has become clear that vitamin D exerts anti-inflammatory and immunomodulatory effects, apart from its well-established role in the regulation of calcium homeostasis and bone metabolism. Importantly, the global incidence of vitamin D deficiency is also dramatically increasing and epidemiologic evidence suggests an involvement of vitamin D deficiency in T1D pathogenesis.

Polymorphisms in genes critical for vitamin D metabolism have also been shown to modulate the risk of T1D.

Moreover, several studies have investigated the role of vitamin D (in different doses and formulations) as a potential adjuvant immunomodulatory therapy in patients with new-onset and established T1D.

This review aims to present the current knowledge on the immunomodulatory effects of vitamin D and summarize the clinical interventional studies investigating its use for prevention or treatment of T1D.

Created by admin. Last Modification: Saturday September 14, 2019 14:29:36 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
12641 T1D ToC.jpg admin 14 Sep, 2019 14:19 53.05 Kb 36
12640 T1D immune system.jpg admin 14 Sep, 2019 14:19 56.79 Kb 41
12639 T1D 156 trials.pdf PDF 2019 admin 14 Sep, 2019 14:11 1.02 Mb 37
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