Effects of Maternal Vitamin D Supplementation During Pregnancy and Lactation on Infant Acute Respiratory Infections: Follow-up of a Randomized Trial in Bangladesh
J Pediatric Infect Dis Soc. 2021 Jul 2;piab032. doi: 10.1093/jpids/piab032
Shaun K Morris 1 2 3 4, Lisa G Pell 1, Mohammed Ziaur Rahman 5, Abdullah Al Mahmud 6, Joy Shi 1 7, Tahmeed Ahmed 6, Michelle C Dimitris 1, Jonathan B Gubbay 2 8, M Munirul Islam 6, Tahmid Kashem 9, Farhana K Keya 6, Minhazul Mohsin 6, Eleanor Pullenayegum 3 10, Michelle Science 2 4, Shaila S Shanta 6, Mariya K Sumiya 5, Stanley Zlotkin 1 2 3, Daniel E Roth 1 2 3
I suspect that ~50,000 IU weekly to the mother or ~600 IU daily to the infant would have reduced RTI
Items in categories Breathing + Intervention + Infant:
- Infant Respiratory Infections not reduced by mothers taking small amount of vitamin D (28,000 weekly)– RCT July 2021
- Lower Respiratory Tract Infection in Infants reduced 5.9 X by daily 600 IU of vitamin D (China) - March 2020
- Allergic Rhinitis in infants treated by 1,000 IU vitamin D daily – June 2019
- Childhood Respiratory Health hardly improved with 600 IU of vitamin D (need much more) – May 2018
- Allergic rhinitis in children reduced somewhat during pollen season by just 1,000 IU of vitamin D – RCT Jan 2018
- Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT Jan 2018
- Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017
- Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
- Five times less mite allergy when vitamin D added in mid pregnancy and to infant – RCT April 2016
- Respiratory Tract visits 2.5 less likely with vitamin D: Pregnancy 2000 IU, Infant 800 IU – RCT Oct 2014
- 2000 IU of vitamin D should improve toddlers health in winter – RCT almost completed Feb 2014
- Recurrence of child pneumonia delayed by 100000 IU of vitamin D – RCT Oct 2010
Background: We examined the effect of maternal vitamin D supplementation during pregnancy and lactation on risk of acute respiratory infection (ARI) in infants up to 6 months of age in Bangladesh.
Methods: This study was nested in a randomized, double-blind, placebo-controlled, 5-arm dose-ranging trial of prenatal and postpartum vitamin D supplementation.
- One group of women received 0 IU vitamin D per week during pregnancy and for 26 weeks post delivery ("placebo" group),
- one group received high-dose prenatal vitamin D supplementation of 28 000 IU per week and 26 weeks post delivery, and there were
- 3 additional dose-ranging groups receiving vitamin D supplementation during pregnancy only (4200, 16 800, and 28 000 IU per week, respectively).
Episodes of ARI were identified by active and passive surveillance. The primary outcome was microbiologically confirmed ARI, and the primary analysis compared the high-dose prenatal plus postpartum vitamin D vs placebo groups.
Results: In total, 1174 mother-infant pairs were included. Among infants born to mothers in the placebo group, 98% had a venous umbilical cord 25(OH)D level below 30 nmol/L compared with none in the high-dose prenatal plus postdelivery vitamin D group. Incidence of microbiologically confirmed ARI in the high-dose prenatal plus postpartum vitamin D (1.21 episodes per 6 person-months; N = 235) and placebo groups (1.07 episodes per 6 person-months; N = 234) was not significantly different (hazard ratio of 1.12 [95% confidence intervals: 0.90-1.40]). There were no differences in the incidence of microbiologically confirmed or clinical ARI, upper, lower, or hospitalized lower respiratory tract infection between high-dose prenatal plus postpartum vitamin D and placebo groups.
Conclusions: Despite a high prevalence of maternal baseline vitamin D deficiency and significant effects of maternal vitamin D supplementation on infant vitamin D status, the intervention did not reduce the risk of microbiologically confirmed ARI in infants up to 6 months of age.