Table of contents
- Metabolomics analysis reveals molecular linkages for the impact of vitamin D on childhood allergic airway diseases
- 18,000 studies for metabolome and "vitamin D" in Google Scholar May 2022
- VitaminDWiki -
80 studies in both categories Breathing and Infant-Child
Metabolomics analysis reveals molecular linkages for the impact of vitamin D on childhood allergic airway diseases
Pediatr Allergy Immunol 2022 May;33(5):e13785. doi: 10.1111/pai.13785.PDF is behind paywall
Yu-Ho Chang 1, Kuo-Wei Yeh 2, Jing-Long Huang 2 3, Kuan-Wen Su 4, Ming-Han Tsai 4, Man-Chin Hua 4, Sui-Ling Liao 4, Shen-Hao Lai 5, Li-Chen Chen 2 3, Chih-Yung Chiu 5Background: Several studies have reported the relevance between serum vitamin D and allergic immunoglobulin E (IgE) responses and atopic diseases. However, a metabolomics-based approach to the impacts of vitamin D on allergic reactions remains unclear.
Methods: A total of 111 children completed a 3-year follow-up were enrolled and classified based on longitudinal vitamin D status (≥ 30 ng/ml, n = 54; 20-29.9 ng/ml, n = 41; <20 ng/ml, n = 16). Urinary metabolomic profiling was performed using 1 H-Nuclear magnetic resonance (NMR) spectroscopy at age 3. Integrative analyses of their associations related to vitamin D levels, atopic indices, and allergies were performed, and their roles in functional metabolic pathways were also assessed.
Results: Six and five metabolites were identified to be significantly associated with vitamin D status and atopic diseases, respectively (FDR-adjusted p-value <.05). A further correlation analysis revealed that vitamin D-associated 3-hydroxyisobutyric acid and glutamine were positively correlated with atopic disease-associated succinic acid and alanine, respectively. Furthermore, hippuric acid was negatively correlated with atopic disease-associated formic acid, which was positively correlated with vitamin D level (p < .01). Absolute eosinophil count (AEC) was positively correlated with serum D. pteronyssinus- and D. farinae-specific IgE level (p < .01) but negatively correlated with vitamin D level (p < .05). Amino acid metabolisms were significantly associated with vitamin D related to childhood allergies.
Conclusion: Integrative metabolomic analysis provides the link of vitamin D-associated metabolites with the gut microbiome and immunoallergic reactions related to childhood allergies.
18,000 studies for metabolome and "vitamin D" in Google Scholar May 2022
Google Scholar includes:
- The vitamin D metabolome: An update on analysis and function - 2019
- The serum vitamin D metabolome: What we know and what is still to discover - 2018 PDF from Sci-Hub via VitaminDWiki
- Metabolomic basis for response to high dose vitamin D in critical illness - 2021 PDFi
- Serum 25-hydroxyvitamin D, metabolome, and bronchiolitis severity among infants: A multicenter cohort study - 2018 PDFi
- Metabolomics in the prevention and management of asthma - 2019 PDFi
VitaminDWiki -
80 studies in both categories Breathing and Infant-Child This list is automatically updated
- 3X reduction in respiratory infections in children taking more than 800 IU of Vitamin D weekly – Nov 2024
- Risk of childhood pneumonia reduced 30% by high Vitamin D - Oct 2024
- Bronchopulmonary dysplasia, in a third of preemies, 87% reduced risk for just 1 ng higher Vitamin D level – Oct 2024
- Infant respiratory distress reduced by Vitamin D – meta-analysis July 2024
- Vitamin D levels are low during Recurrent Wheezing - Feb 2024
- Obese asthmatic children Vitamin D - 50,000 IU then 8,000 IU daily - RCT Jan 2024
- France has injected 200,000 infants with RSV vaccine, based on no long-term data - Here we go again - Dec 2023
- Respiratory infections in children 6 X more likely if low Vitamin D (avg of 2 studies) - Aug 2023
- Prevention of allergies, eczema, asthma, in children – Vitamin D during pregnancy is a principal solution – July 2023
- Respiratory infection, children and Vitamin D - many studies
- Asthma by age 7 if wheezing before preschools and poor vitamin D Receptor - May 2023
- 3% fewer respiratory problems in children if single 100K vitamin D in 3rd trimester – May 2023
- Chronic tonsillitis virtually eliminated in children by Vitamin D (50,000 IU weekly) – RCT May 2023
- RSV kills 100,000 children annually around the world (Vitamin D can help)– May 2022
- Small doses of Vitamin D do not reduce childhood breathing allergies – meta-analysis Oct 2022
- Vitamin D reduces childhood allergic airway diseases (confirmed by metabolomics this time) – May 2022
- Wheezing and asthmatic children have weaker Vitamin D responses - May 2022
- Croup (due to viruses) has surged with Omicron - March 2022
- Allergy medications may be improved by Vitamin D (6X for birch pollen in this case) – Aug 2021
- Infant Respiratory Infections not reduced by mothers taking small amount of vitamin D (28,000 weekly)– RCT July 2021
- Recurrent RTI treatment success: Conventional 71 pcnt, Vitamin D 96 pcnt – March 2021
- The 6 percent of infants hospitalized for ARI are 2.2 X more likely to be Vitamin D deficient – April 2021
- Acute pneumonia in children 3X less likely if greater than 30 ng of vitamin D – Jan 2021
- Preemie Respiratory Distress Syndrome is 5X more likely if low vitamin D – Dec 2020
- Recurrent Wheezing in children is associated with low Vitamin D – several studies
- Respiratory viral infection (RSV) and low vitamin D - many studies
- Lower Respiratory Tract Infection in Infants reduced 5.9 X by daily 600 IU of vitamin D (China) - March 2020
- Gene that predicts wheezing is associated with low vitamin D – Oct 2019
- Bronchiolitis in children associated with both pollution and low solar – July 2019
- Allergic Rhinitis in infants treated by 1,000 IU vitamin D daily – June 2019
- Asthmatic children 5X more likely to have a poor Vitamin D Receptor – June 2019
- Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019
- Childhood Asthma somewhat reduced by 2400 IU vitamin D late in pregnancy (néed more, earlier) March 2019
- Respiratory Distress Syndrome in preemies 5 X more likely if poor vitamin D receptor – Feb 2019
- Black infant recurrent wheezing rate dropped from 42 percent to 31 percent with just 400 IU of vitamin D – RCT Dec 2018
- Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
- Immature lungs in immature newborns – Vitamin D helps – Sept 2018
- Bronchiolitis had 1.3 X longer hospitalization if low Vitamin D (1016 infants) – Sept 2018
- Pneumonia in Egyptian Children 3.6 X more likely if poor Vitamin D Receptor – Aug 2018
- Childhood pneumonia not treated by 100,000 IU of vitamin D – Cochrane (need more, inhaled) – July 2018
- Pneumonia is increasing (now 1 in 6 child deaths), more vitamin D studies needed – June 2018
- Childhood Respiratory Health hardly improved with 600 IU of vitamin D (need much more) – May 2018
- Indoor pollution is a problem with obese black asthmatic children – May 2018
- Both parents smoke – child’s vitamin D level was 30 percent lower and worse asthma – May 2018
- Allergic rhinitis in children reduced somewhat during pollen season by just 1,000 IU of vitamin D – RCT Jan 2018
- Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT Jan 2018
- Rapid newborn breathing (transient tachypnea) associated with low vitamin D – Dec 2017
- Preemies with poor lungs (Respiratory distress syndrome) have low levels of vitamin D – Nov 2017
- Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017
- Respiratory infection in infant was 7 X more likely if low cord Vitamin D – March 2017
Vitamin D reduces childhood allergic airway diseases (confirmed by metabolomics this time) – May 2022Printer Friendly Follow this page for updates637 visitors, last modified 26 May, 2022, This page is in the following categories (# of items in each category)Attached files
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