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Childhood asthma still reduced 4 months after 800 IU of Vitamin D daily - RCT Feb 2016

Improved Control of Childhood Asthma with Low-Dose, Short-Term Vitamin D Supplementation: A Randomized, Double-Blind, Placebo-Controlled Trial.

Allergy. 2016 Feb 3. doi: 10.1111/all.12856. [Epub ahead of print]
Tachimoto H1, Mezawa H1,2, Segawa T1,3, Akiyama N1,3, Ida H1, Urashima M1,2.
1Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan.
2Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan.
3Department of Pediatrics, Fuji Chuo Hospital, Shizuoka, Japan.

VitaminDWiki Summary
  • 800 IU daily raised levels from 28 ng to 32 ng @ 2 months
  • Vitamin D supplementation for only 2 months
  • at 6 months (4 months after supplementation stopped)
    only 15 % of children who had Vitamin D had poor air flow rate
    vs 35% who had no added vitamin D

Comment

  1. 800 IU is not very much
  2. Would have probably been better if a loading dose had first been used

See also VitaminDWiki

BACKGROUND:
In our prior randomized trial on preventing influenza, asthma attacks as a secondary outcome occurred less often in the vitamin D group than the placebo group. We aimed to clarify whether low-dose, short-term vitamin D supplementation, in addition to standard treatments, improves control of childhood asthma.

METHODS:
We conducted a randomized, double-blind, placebo-controlled trial comparing vitamin D3 supplements (800 IU/day) with placebo for 2 months in schoolchildren with asthma. The primary outcomes were frequency and severity of asthma judging from changes of asthma control levels defined by the Global Initiative for Asthma (GINA) by collaborating doctors at 2 and 6 months.

RESULTS:
Japanese schoolchildren with asthma (n=89) were randomly assigned to receive vitamin D (n=54) or placebo (n=35). At 2 months, GINA asthma control was significantly more improved in the vitamin D group compared with the placebo group (P=0.015). Childhood asthma control test (CACT) scores, a secondary outcome, were also significantly (P=0.004) improved in the vitamin D group compared with the placebo group at 2 months, and differences remained significant (P=0.012) at 6 months. The proportion of patients with a peak expiratory flow rate <80% predicted was significantly less in the vitamin D group (8/54: 15%) than the placebo group (12/35: 34%) at 6 months (P=0.032).

CONCLUSIONS:
Low-dose, short-term vitamin D supplementation in addition to standard treatment may improve levels of asthma control in schoolchildren.

This article is protected by copyright. All rights reserved. PMID: 26841365

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Described at Vitamin D Council

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