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Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017

Trial of vitamin D supplementation to prevent asthma exacerbation in children

Int. J of Research in Medical Science, Vol 5, No 6 (2017),
   DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20172479
Elango Krishnan, Venmugil Ponnusamy, Sathiya Priya Sekar


Loading: intramuscular vitamin D injection 300,000-600,000 IU over 1-5 days
Maintenance: oral vitamin D 600 IU + calcium (30-70 mg/kg/day) for 3 months
57% 5-8 years, 23% 9-10 years, 20% 11-12 years

  • This was not a randomized controlled trial (RCT) - all of the children with asthma got the Vitamin D
  • Since it was not a RCT it will not probably be be included in any meta-analyses of Asthma and Vitamin D
  • Maintenance Dose: strangely it was too small and not proportional to body weight - as the calcium dose was
  • Injection is nice, but not essential

 Download the PDF from VitaminDWiki

Decreased Emergency room visits


Decreased hospital visits


Decreased need for reliever inhalent
   82% < 2 days per week 3 months after stop of daily vitamin D


Background: To assess the level of vitamin D in children with bronchial asthma and to study the effects of vitamin D supplementation in asthmatic children who had vitamin D deficiency in terms of asthma control test score and Number of exacerbations.

Methods: This interventional study was conducted in Department of Paediatrics, KAPV Government medical college, Trichy, Tamil Nadu, India from September 2016 to February 2017. 96 asthmatic children of age group 5-12 years who attended outpatient department and admitted in ward for asthma exacerbation were selected. After assessing their Vitamin D level, Vitamin D supplementation given along with standard treatment for asthma. Outcomes measured were ACTS (Asthma control test score), number of emergency room visits, number of hospital admissions and reliever medication use.

Results: Out of 96 children, 83 (86.4%) children had vitamin D deficiency. There was significant correlation between vitamin D level and absolute eosinophil count (p-value-0.037), asthma severity (p-value<0.001) and asthma control (p-value<0.001). Significant reduction in emergency room visits, (p-value<0.001) reliever medication use (p-value<0.001) and improvement in asthma control test score (p-value-0.008) occurs after vitamin D supplementation.

Conclusions: There is a significant correlation between vitamin D level, asthma severity and its control. Asthma exacerbation in terms of emergency room visits and reliever medication use were further reduced by vitamin D supplementation.


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Attached files

ID Name Comment Uploaded Size Downloads
8052 Ashtma reliever.jpg admin 01 Jun, 2017 15:50 35.98 Kb 1541
8051 Asthma Hospital.jpg admin 01 Jun, 2017 15:50 35.78 Kb 1449
8050 Asthma ER.jpg admin 01 Jun, 2017 15:50 35.82 Kb 1670
8049 Treat asthma.pdf PDF 2017 admin 01 Jun, 2017 15:27 351.08 Kb 966
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