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Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017

Trial of vitamin D supplementation to prevent asthma exacerbation in children

Int. J of Research in Medical Science, Vol 5, No 6 (2017),
   DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20172479
Elango Krishnan, Venmugil Ponnusamy, Sathiya Priya Sekar


Loading: intramuscular vitamin D injection 300,000-600,000 IU over 1-5 days
Maintenance: oral vitamin D 600 IU + calcium (30-70 mg/kg/day) for 3 months
57% 5-8 years, 23% 9-10 years, 20% 11-12 years

  • This was not a randomized controlled trial (RCT) - all of the children with asthma got the Vitamin D
  • Since it was not a RCT it will not probably be be included in any meta-analyses of Asthma and Vitamin D
  • Maintenance Dose: strangely it was too small and not proportional to body weight - as the calcium dose was
  • Injection is nice, but not essential

 Download the PDF from VitaminDWiki

Decreased Emergency room visits


Decreased hospital visits


Decreased need for reliever inhalent
   82% < 2 days per week 3 months after stop of daily vitamin D


Background: To assess the level of vitamin D in children with bronchial asthma and to study the effects of vitamin D supplementation in asthmatic children who had vitamin D deficiency in terms of asthma control test score and Number of exacerbations.

Methods: This interventional study was conducted in Department of Paediatrics, KAPV Government medical college, Trichy, Tamil Nadu, India from September 2016 to February 2017. 96 asthmatic children of age group 5-12 years who attended outpatient department and admitted in ward for asthma exacerbation were selected. After assessing their Vitamin D level, Vitamin D supplementation given along with standard treatment for asthma. Outcomes measured were ACTS (Asthma control test score), number of emergency room visits, number of hospital admissions and reliever medication use.

Results: Out of 96 children, 83 (86.4%) children had vitamin D deficiency. There was significant correlation between vitamin D level and absolute eosinophil count (p-value-0.037), asthma severity (p-value<0.001) and asthma control (p-value<0.001). Significant reduction in emergency room visits, (p-value<0.001) reliever medication use (p-value<0.001) and improvement in asthma control test score (p-value-0.008) occurs after vitamin D supplementation.

Conclusions: There is a significant correlation between vitamin D level, asthma severity and its control. Asthma exacerbation in terms of emergency room visits and reliever medication use were further reduced by vitamin D supplementation.


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Attached files

ID Name Comment Uploaded Size Downloads
8052 Ashtma reliever.jpg admin 01 Jun, 2017 35.98 Kb 1731
8051 Asthma Hospital.jpg admin 01 Jun, 2017 35.78 Kb 1648
8050 Asthma ER.jpg admin 01 Jun, 2017 35.82 Kb 1881
8049 Treat asthma.pdf admin 01 Jun, 2017 351.08 Kb 1102