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2.4 X fewer lower respiratory track infections in infants getting 400 IU of Vitamin D – May 2022

Vitamin D supplementation and lower respiratory tract infection in infants: a nested case-control study

Infection. 2022 May 24. doi: 10.1007/s15010-022-01845-4
Miao Hong 1, Ting Xiong 1, Junmei Huang 1 2, Yuanjue Wu 1, Lixia Lin 1, Zhen Zhang 1, Li Huang 1, Qin Gao 1, Huanzhuo Wang 1, Xuefeng Yang 1, Nianhong Yang 1, Liping Hao 3


Purpose: To assess the association between vitamin D (VD) supplementation and the risk of lower respiratory tract infection (LRTI) among infants.

Methods: This is a nested case-control study from an ongoing prospective birth cohort in Wuhan from 2013. Cases were subjects free of neonatal pneumonia but later developed LRTI during infancy, who were matched with five randomly selected controls by infant sex, birth year, and birth season. We included 190 cases and 950 controls in the final analysis. The primary outcome was the first LRTI incident and the exposure was VD supplementation from birth to the index endpoint. The association between VD supplementation and LRTI risk was assessed using the Cox proportional-hazards regression model.

Results: Infants taking supplements had a 59% relative reduction in the hazard ratio of LRTI (HR = 0.41; 95% CI 0.26, 0.64) compared to those not supplemented. There was a linear relationship between LRTI risk and VD supplementation within range of 0-603 IU/day: for each 100 IU per day increment in VD supplementation, infants experienced a 21% lower risk of developing LRTI (adjusted HR: 0.79; 95% CI 0.71, 0.89). The linear relationship was stably observed in the sensitivity analyses as well.

Conclusions: VD supplementation was associated with the reduced risk of LRTI throughout infancy, and the optimal supplementation dose for infants may be beyond the current recommendation.
 Download the PDF from VitaminDWiki

Note: This case-controlled study uses 9 year old data from China

Note: Lower RTI is often due to the influenza virus

Note: A 1 year old child should get 1,000 IU daily average
  • 100 IU per kg of infant July 2011, Poland etc.
    1000 IU per 25 lbs.jpg
    Slighly better and easier to remember for 1 year old child would be
    5,000 IU weekly, 10,000 IU bi-weekly, of 50,000 IU monthly

VitaminDWiki pages with LOWER RESPIRATORY in title (9 as of May 2022)

This list is automatcially updated

Items found: 9

VitaminDWiki pages with RTI in title (9 as of May 2022)

This list is automatcially updated

Items found: 10

VitaminDWiki Infant-Child pages with PNEUMONIA in title (8 as of May 2022)

This list is automatcially updated

Items found: 9

Respiratory Virus Infections: Understanding COVID-19 - May 2020


Created by admin. Last Modification: Tuesday May 24, 2022 23:54:06 GMT-0000 by admin. (Version 16)

Attached files

ID Name Comment Uploaded Size Downloads
17650 Lower Respiratory.jpg admin 24 May, 2022 30.82 Kb 186
17649 LRTI.jpg admin 24 May, 2022 17.03 Kb 163
17648 LRTI Chart.jpg admin 24 May, 2022 33.25 Kb 203
17647 Lower RTI_CompressPdf.pdf admin 24 May, 2022 756.18 Kb 161