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Childhood Asthma somewhat reduced by 2400 IU vitamin D late in pregnancy (néed more, earlier) March 2019

High-Dose Vitamin D Supplementation During Pregnancy and Asthma in Offspring at the Age of 6 Years

JAMA. 2019;321(10):1003-1005. doi:10.1001/jama.2019.0052
Nicklas Brustad, MD1; Anders U. Eliasen, MSc1; Jakob Stokholm, MD, PhD1; et al Klaus Bønnelykke, MD, PhD1; Hans Bisgaard, MD, DMSc1; Bo L. Chawes, MD, PhD, DMSc1

 Download the PDF from Sci-Hub via VitaminDWiki

2400 IU started at 24th week of pregnancy did not result in a statistically significant decrease

Probably not achieve a good level until week 34, but needed a good level at week 4

Evidence suggests that low in utero vitamin D levels may be associated with risk of asthma in offspring.1 The Copenhagen Prospective Studies on Asthma in Childhood 2010 vitamin D randomized clinical trial (RCT) found that at the age of 3 years, children of women randomized to high-dose vs standard-dose vitamin D did not have a statistically significant reduced risk of persistent wheeze; however, a clinically important protective effect could not be excluded (hazard ratio, 0.76 [95% CI, 0.52-1.12]).2 Because diagnosing asthma early in life is difficult, we followed up the children at the age of 6 years to assess the risk of current asthma.

Created by admin. Last Modification: Saturday June 22, 2019 16:53:26 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
11550 Wheese or asthma 3 years.jpg admin 12 Mar, 2019 17:31 18.17 Kb 392
11549 Asthma age 6.pdf PDF 2019 admin 12 Mar, 2019 17:30 188.07 Kb 449