High-Dose Vitamin D Supplementation During Pregnancy and Asthma in Offspring at the Age of 6 Years
JAMA. 2019;321(10):1003-1005. doi:10.1001/jama.2019.0052
Nicklas Brustad, MD1; Anders U. Eliasen, MSc1; Jakob Stokholm, MD, PhD1; et al Klaus Bønnelykke, MD, PhD1; Hans Bisgaard, MD, DMSc1; Bo L. Chawes, MD, PhD, DMSc1
The best reduction in childhood asthma comes results from a good level of vitamin D at 4 week of pregnancy, when lung development starts
- Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017
- Reduction of infant asthma may require good vitamin D when lung development starts (4 weeks) – March 2017
- Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019
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Ensure a healthy pregnancy and baby - take Vitamin D before conception has the following
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2400 IU started at 24th week of pregnancy did not result in a statistically significant decrease
Probably not achieve a good level until week 34, but needed a good level at week 4
Evidence suggests that low in utero vitamin D levels may be associated with risk of asthma in offspring.1 The Copenhagen Prospective Studies on Asthma in Childhood 2010 vitamin D randomized clinical trial (RCT) found that at the age of 3 years, children of women randomized to high-dose vs standard-dose vitamin D did not have a statistically significant reduced risk of persistent wheeze; however, a clinically important protective effect could not be excluded (hazard ratio, 0.76 [95% CI, 0.52-1.12]).2 Because diagnosing asthma early in life is difficult, we followed up the children at the age of 6 years to assess the risk of current asthma.
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