Toggle Health Problems and D

Wheezing and asthmatic children have weaker Vitamin D responses - May 2022

Vitamin D replacement in children with acute wheeze: a dose-escalation study

ERJ Open Research 2022 8: 00609-2021; DOI: 10.1183/23120541.00609-2021
Christos Stefanidis, Andrew Bush, Christopher Newby, Chinedu Nwokoro, Susan Liebeschuetz, Imogen P. Skene, Christopher J. Griffiths, Adrian R. Martineau

Vitamin D supplementation at the current UK recommended level (400 IU·day−1) or enhanced supplementation (1000 IU·day−1) failed to achieve adequate levels of vitamin D (>75 nmol·L−1) in vitamin-D-insufficient children with acute wheeze https://bit.ly/3J43Ouo


To the Editor:

Meta-analyses report protective effects of vitamin D supplementation against asthma exacerbations and acute respiratory infections in adults [1–3], but data relating to effects of vitamin D on risk of preschool wheeze and asthma attacks in childhood are more limited [4]. In preparation for a randomised controlled trial (RCT) of vitamin D in children with recurrent preschool wheeze or school-age asthma, we carried out a dose-escalation study to find the daily vitamin D3 supplementation regimen that is most effective in elevating circulating 25-hydroxyvitamin D (25(OH)D) concentrations in these children. We hypothesised that daily oral vitamin D3 supplementation of 1000 IU would be more effective than 400 IU (UK recommendation [5]) in elevating the circulating 25(OH)D concentration to ≥75 nmol·L−1 at 3 months in vitamin-D-insufficient children with recurrent preschool wheeze or school-age asthma.

Children were recruited from primary and secondary care if they were aged 1–4 years with ≥2 self-reported episodes of acute wheeze requiring unscheduled healthcare attendances in the preceding year (preschool children), or aged 5–12 years with doctor-diagnosed asthma and ≥1 self-reported asthma attack requiring an unscheduled healthcare attendance in the preceding year (school children). Exclusion criteria were baseline 25(OH)D level ≥75 nmol·L−1, concurrent vitamin D supplementation, or a history of other chronic or acute respiratory or systemic conditions.
 Download the PDF from VitaminDWiki

Study should have increased the dose size with increased weight or age

1000 IU per 25 lbs.jpg
Example: 1000 IU at 25 lbs, 3,000 IU at age 9


Created by admin. Last Modification: Thursday August 31, 2023 11:00:18 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
17628 breathing 400 and 1000 IU.jpg admin 19 May, 2022 19:53 78.04 Kb 146
17627 RTI 400 1000.pdf PDF 2022 admin 19 May, 2022 19:53 271.73 Kb 88