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Small doses of Vitamin D do not reduce childhood breathing allergies – meta-analysis Oct 2022


Vitamin D Supplementation and Allergic Diseases during Childhood: A Systematic Review and Meta-Analysis

Nutrients 2022, 14(19), 3947; https://doi.org/10.3390/nu14193947
by Qinyuan Li et al China

We performed a systematic review and meta-analysis to investigate the effects of vitamin D (VitD) supplementation on children with allergic diseases. MEDLINE, Embase, Web of Science, the Cochrane library, and three Chinese databases were searched up to 15 August 2022. Randomized controlled trials (RCTs) comparing a VitD supplementation versus a placebo for children with allergic diseases were included. Thirty-two RCTs with 2347 participants were included.

  • VitD supplementation did not reduce the risk of asthma exacerbations in children compared with placebo overall (risk ratio (RR) = 0.84, 95% confidence interval (CI): 0.65 to 1.08, p = 0.18), but
  • reduced the risk of asthma exacerbation in children with baseline serum 25(OH)D of <10 ng/mL compared with placebo (RR = 0.48, 95% CI: 0.28 to 0.83, p = 0.009).
  • VitD supplementation significantly reduced Scoring Atopic Dermatitis or the Eczema Area and Severity Index scores in children with atopic dermatitis compared with placebo (standard mean difference = −0.5, 95% CI: −0.87 to −0.12, p = 0.009).
  • VitD supplementation also reduced the symptom-medication score in children with allergic rhinitis compared with placebo (mean (standard deviation): 43.7 (3.3) vs. 57.8 (4.4), p = 0.001).

In conclusion, VitD supplementation did not reduce asthma exacerbation risk in children overall but may reduce asthma exacerbation risk in children with serum 25(OH)D concentration < 10 ng/mL. VitD supplementation reduces the severity of atopic dermatitis and symptoms of allergic rhinitis in children
 Download the PDF from VitaminDWiki


About half of the studies used <2,000 IU doses daily

Third study found that Infants needed 1600 IU of vitamin D – JAMA RCT May 2013
Need even larger doses for heavier (older) patients and those who are not healthy


See in VitaminDWiki - Allergy - Overview Overview Asthma and Vitamin D


VitaminDWiki - 76 studies in both categories Breathing and Infant/Child

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Created by admin. Last Modification: Tuesday October 18, 2022 02:32:26 GMT-0000 by admin. (Version 6)

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18659 Allergic meta_CompressPdf.pdf admin 18 Oct, 2022 325.92 Kb 165