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Rapid newborn breathing (transient tachypnea) associated with low vitamin D – Dec 2017

Maternal and neonatal vitamin D deficiency and transient tachypnea of the newborn in full term neonates

Online: 2017-12-21 | DOI: https://doi.org/10.1515/jpm-2017-0280
Ahmed Omran, Heba Mousa, Mohamed Osama Abdalla, Osama Zekry

Aim:
To investigate the association between maternal and neonatal serum 25-hydroxyvitamin D (25-OHD) levels and development of transient tachypnea of the newborn (TTN) in full term infants.

Methods:
This was a prospective case-control study carried out on 30 neonates with TTN and their mothers and 30 control neonates and their mothers. Levels of 25-OHD were measured in maternal and neonatal blood samples that were obtained in the first 12–24 h of postnatal age.

Results:
Both maternal and neonatal 25-OHD levels in the TTN group were significantly lower compared to the control group (P=0.0001). A negative correlation was observed between neonatal 25-OHD level and average hospital stay (P=0.0001).

Conclusion:
We observed that lower maternal and neonatal vitamin 25-OHD levels were associated with TTN development in full term infants.

Publisher wants $42 for the PDF

References

  • 1] Nguyen M, Trubert CL, Rizk-Rabin M, Rehan VK, Besançon F, Cayre YE, et al. 1,25-Dihydroxyvitamin D3 and fetal lung maturation: immunogold detection of VDR expression in pneumocytes type II cells and effect on fructose 1,6 bisphosphatase. J Steroid Biochem Mol Biol. 2004;89–90:93–7.
  • 2] Saadoon A, Ambalavanan N, Zinn K, Ashraf AP, MacEwen M, Nicola T, et al. Effect of prenatal versus postnatal vitamin D deficiency on pulmonary structure and function in mice. Am J Respir Cell Mol Biol. 2017;56:383–92.
  • 3] Shor DB, Barzel J, Tauber E, Amital H. The effects of maternal vitamin D on neonatal growth parameters. Eur J Pediatr. 2015;174:1169–74.
  • 4] Onwuneme C, Martin F, McCarthy R, Carroll A, Segurado R, Murphy J, et al. The association of vitamin D status with acute respiratory morbidity in preterm infants. J Pediatr. 2015;166:1175–80.
  • 5] Konca C, Kahramaner Z, Bulbul M, Erdemir A, Tekin M, Ercan S, et al. Association between serum 25-hydroxyvitamin D levels and TTN. Horm Res Paediatr. 2014;81:397–401.
  • 6] Çetinkaya M, Çekmez F, Erener-Ercan T, Buyukkale G, Demirhan A, Aydemir G, et al. Maternal/neonatal vitamin D deficiency: a risk factor for bronchopulmonary dysplasia in preterms? J Perinatol. 2105;35:813–7.
  • 7] Dinlen N, Zenciroglu A, Beken S, Dursun A, Dilli D, Okumus N. Association of vitamin D deficiency with acute lower respiratory tract infections in newborns. J Matern Fetal Neonatal Med. 2016;29:928–32.
  • 8] Dawodu A, Zalla L, Woo JG, Herbers PM, Davidson BS, Heubi JE, et al. Heightened attention to supplementation is needed to improve the vitamin D status of breastfeeding mothers and infants when sunshine exposure is restricted. Matern Child Nutr. 2014;10:383–97.
  • 9] Thandrayen K, Pettifor JM. Maternal vitamin D status: implications for the development of infantile nutritional rickets. Endocrinol Metab Clin North Am. 2010;39:303–20.
  • 10] Cetinkaya M, Cekmez F, Buyukkale G, Erener-Ercan T, Demir F, Tunc T, et al. Lower vitamin D levels are associated with increased risk of early-onset neonatal sepsis in term infants. J Perinatol. 2015;35:39–45.
  • 11] Chen L, Wilson R, Bennett E, Zosky GR. Identification of vitamin D sensitive pathways during lung development. Respir Res. 2016;17:47.
  • 12] James DK, Chiswick ML, Harkes A, Williams M, Hallworth J. Non-specificity of surfactant deficiency in neonatal respiratory disorders. Br Med J (Clin Res Ed). 1984;288:1635–8.
  • 13] Bhuta T, Kent-Biggs J, Jeffery HE. Prediction of surfactant dysfunction in term infants by the click test. Pediatr Pulmonol. 1997;23:287–91.
  • 14] Machado LU, Fiori HH, Baldisserotto M, Ramos Garcia PC, Vieira AC, Fiori RM. Surfactant deficiency in transient tachypnea of the newborn. J Pediatr. 2011;159:750–4.

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